Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Sequence P01193

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Evidence	Reference
26	unknown peptidase	1-235	P	NT	<%Agarwal et al., 2012[]%>
75	PCSK2 peptidase	27-235	P		Seidah & Chretien, 1994
102	PCSK2 peptidase	27-235	P		Benjannet et al., 1991
121	unknown peptidase	1-235	P	NT	<%Agarwal et al., 2012[]%>
123	yapsin-1	27-235	N	AB	Azaryan et al., 1993
123	furin-1 (arthropod-type)	27-235	N		De Bie et al., 1995
123	furin-2 (insect)	27-235	N		De Bie et al., 1995
123	kexin	27-235	N		Thomas et al., 1991
123	PCSK1 peptidase	27-235	P		Benjannet et al., 1991
123	PCSK2 peptidase	27-235	P		Benjannet et al., 1991
140	PCSK2 peptidase	27-235	P		Benjannet et al., 1991
164	yapsin-1	27-235	N	AB	Azaryan et al., 1993
164	furin-1 (arthropod-type)	27-235	N		De Bie et al., 1995
164	furin-2 (insect)	27-235	N		De Bie et al., 1995
164	kexin	27-235	N		Thomas et al., 1991
164	PCSK1 peptidase	27-235	P		Benjannet et al., 1991
164	PCSK2 peptidase	27-235	P		Benjannet et al., 1991
204	yapsin-1	27-235	N	AB	Azaryan et al., 1993
204	kexin	27-235	N		Thomas et al., 1991
204	PCSK1 peptidase	27-235	P		Benjannet et al., 1991
204	PCSK2 peptidase	27-235	P		Benjannet et al., 1991
233	PCSK1 peptidase	27-235	P		<%Benjannet et al., 1991[]%>
233	PCSK2 peptidase	27-235	P		Seidah & Chretien, 1994