Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P56817

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	unknown peptidase	1-501	P		NT	<%Agarwal et al., 2012[]%>
24	BACE1 g.p. (Homo sapiens)	22-501	P	release of an activation peptide		Lin et al., 2000
42	clostripain	13-501	N			Ermolieff et al., 2000
45	BACE1 g.p. (Homo sapiens)	1-501	P		NT	Sidera et al., 2002
45	kallikrein-related peptidase 4	1-501	P		CS	Matsumura et al., 2005
45	furin	40-49	N		CS	Remacle et al., 2008
45	PCSK2 peptidase	40-49	N		CS	Remacle et al., 2008
45	PCSK4 peptidase	40-49	N		CS	Remacle et al., 2008
45	PCSK6 peptidase	40-49	N		CS	Remacle et al., 2008
45	PCSK5 peptidase	40-49	N		CS	Remacle et al., 2008
45	PCSK7 peptidase	1-501	P		AB	Pinnix et al., 2001
57	clostripain	13-501	N			Ermolieff et al., 2000
99	BACE1 g.p. (Homo sapiens)	46-501	P			Lin et al., 2000
184	BACE1 g.p. (Homo sapiens)	46-501	P	normal turnover		Lin et al., 2000