Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01148

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-92	P	release of a signal peptide	NT	Tan & Rousseau, 1982
25	thimet oligopeptidase	24-33	P		NT	Dando et al., 1993
25	BHRb haemorrhagin (Bitis arietans)	24-33	N			Yamakawa, 2004
26	pyroglutamyl-peptidase I (chordate)	24-33	N			De Gandarias et al., 1994
26	angiotensin-converting enzyme peptidase unit 2	24-33	N			Corvol et al., 2004
26	meprin alpha subunit	24-33	N		NT	Bertenshaw et al., 2001
26	ruberlysin	24-33	N			Tu, 2004
26	penicillolysin	24-33	N			Ichishima, 2004
26	unknown peptidase	24-33	N			Corvol et al., 2004
26	unknown peptidase	24-33	N			Bertenshaw et al., 2001
27	meprin alpha subunit	24-33	N		NT	Bertenshaw et al., 2001
27	BHRb haemorrhagin (Bitis arietans)	24-33	N			Yamakawa, 2004
27	hemorrhagic toxin I (Gloydius halys blomhoffii)	24-33	N			Komori & Nikai, 2004
27	neprilysin	24-33	N		NT	Rose et al., 2002
27	unknown peptidase	24-33	N			Bertenshaw et al., 2001
28	meprin alpha subunit	24-33	N		NT	Bertenshaw et al., 2001
28	BHRa hemorrhagin (Bitis arietans)	24-33	N			Yamakawa, 2004
28	brevilysin L6	24-33	N			Komori & Nikai, 2004
28	BHRb haemorrhagin (Bitis arietans)	24-33	N			Yamakawa, 2004
28	hemorrhagic toxin I (Gloydius halys blomhoffii)	24-33	N			Komori & Nikai, 2004
28	penicillolysin	24-33	N			Ichishima, 2004
28	unknown peptidase	24-33	P			De Camargo et al., 1982
28	unknown peptidase	24-33	N			Bertenshaw et al., 2001
29	calpain-1	24-33	P			McDermott et al., 1985
29	angiotensin-converting enzyme peptidase unit 1	27-33	P		AA	Skidgel & Erdös, 1985
29	meprin alpha subunit	24-33	N		NT	Bertenshaw et al., 2001
29	ruberlysin	24-33	N			Tu, 2004
29	BHRb haemorrhagin (Bitis arietans)	24-33	N			Yamakawa, 2004
29	hemorrhagic toxin I (Gloydius halys blomhoffii)	24-33	N			Komori & Nikai, 2004
29	neprilysin	24-33	N		NT	Rose et al., 2002
29	neprilysin-2	24-33	N		NT	Rose et al., 2002
29	unknown peptidase	24-33	N			Bertenshaw et al., 2001
30	meprin alpha subunit	24-33	N		NT	Bertenshaw et al., 2001
30	unknown peptidase	24-33	N			Corvol et al., 2004
30	unknown peptidase	24-33	N			Bertenshaw et al., 2001
32	hemorrhagic toxin I (Gloydius halys blomhoffii)	24-33	N			Komori & Nikai, 2004
32	prolyl oligopeptidase	24-33	P		CS	Lew et al., 1994
36	PCSK2 peptidase	24-92	P			Seidah & Chretien, 1994