Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P06300

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	unknown peptidase	1-248	P		NT	<%Agarwal et al., 2012[]%>
163	unknown peptidase	1-248	P		NT	<%Agarwal et al., 2012[]%>
165	PCSK1 peptidase	22-248	P			Dupuy et al., 1994
165	PCSK2 peptidase	22-248	P			Seidah & Chretien, 1994
171	nardilysin	166-175	P			Chesneau et al., 1994
176	PCSK1 peptidase	22-248	P			Dupuy et al., 1994
176	PCSK2 peptidase	22-248	P			Seidah & Chretien, 1994
199	unknown peptidase	1-248	P		NT	<%Agarwal et al., 2012[]%>
201	PCSK1 peptidase	22-248	P			Seidah & Chretien, 1994
201	PCSK2 peptidase	22-248	P			Seidah & Chretien, 1994
207	nardilysin	202-218	P			Chesneau et al., 1994
210	PCSK2 peptidase	22-248	P			Dupuy et al., 1994
220	PCSK2 peptidase	22-248	P			Seidah & Chretien, 1994
226	nardilysin	221-233	P			Chesneau et al., 1994
234	furin-1 (arthropod-type)	22-248	N			De Bie et al., 1995
234	furin-2 (insect)	22-248	N			De Bie et al., 1995
234	furin	22-248	P	release of a bioactive peptide	CS	De Bie et al., 1995
234	PCSK1 peptidase	22-255	P			Dupuy et al., 1994
234	PCSK2 peptidase	22-248	P			Seidah & Chretien, 1994