Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P23560

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-247	P		NT	<%Agarwal et al., 2012[]%>
57	site-1 peptidase	19-247	P			<%Seidah et al., 1999[]%>
125	plasmin	19-247	P			Gray & Ellis, 2008
128	kallikrein-related peptidase 4	1-247	P		CS	Matsumura et al., 2005
128	furin	123-132	N		CS	Remacle et al., 2008
128	PCSK2 peptidase	123-132	N		CS	Remacle et al., 2008
128	PCSK4 peptidase	123-132	N		CS	Remacle et al., 2008
128	PCSK6 peptidase	123-132	N		CS	Remacle et al., 2008
128	PCSK5 peptidase	123-132	N		CS	Remacle et al., 2008
128	PCSK7 peptidase	123-132	N		CS	Remacle et al., 2008