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Substrates for peptidase S08.077: PCSK7 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
72 kDa type IV collagenase P08253 96-105 Peptide-Arg101+Cys-Peptide S CS Arg Lys Pro Arg Cys Gly Asn Pro Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 1 Q9UHI8 247-256 Peptide-Arg252+Phe-Peptide S CS Arg Lys Lys Arg Phe Val Ser Ser Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 13 Q76LX8 69-78 Peptide-Arg74+Ala-Peptide S CS Arg Gln Arg Arg Ala Ala Gly Gly Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 2 O95450 254-263 Peptide-Arg259+His-Peptide S CS Arg Ala Arg Arg His Ala Ala Asp Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 2 O95450 82-92 Peptide-Arg88+Ala-Peptide S CS Arg Ala Arg Arg Ala Ala Pro Val Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 3 O15072 244-253 Peptide-Arg249+His-Peptide S CS Arg Arg Arg Arg His Ala Gly Glu Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 4 O75173 207-216 Peptide-Arg212+Phe-Peptide S CS Arg Ala Lys Arg Phe Ala Ser Leu Remacle et al., 2008
Abz-Arg-Asn-Thr-Pro-Arg-Arg-Arg-Lys-Lys-Arg-Gly-Leu-Tyn-Ala Abz-Arg-Asn-Thr-Pro-Arg-Arg-Arg-Lys-Lys-Arg+Gly-Leu-Tyn-Ala S Arg Lys Lys Arg Gly Leu Tyn Ala Basak et al., 2001
Abz-Arg-Asn-Thr-Pro-Arg-Glu-Arg-Arg-Arg-Lys-Lys-Arg-Gly-Leu-Tyn-Ala Abz-Arg-Asn-Thr-Pro-Arg-Glu-Arg-Arg-Arg-Lys-Lys-Arg+Gly-Leu-Tyn-Ala S Arg Lys Lys Arg Gly Leu Tyn Ala Basak et al., 2001
Abz-Arg-Asn-Thr-Pro-Arg-Glu-Arg-Lys-Lys-Arg-Gly-Leu-Tyn-Ala Abz-Arg-Asn-Thr-Pro-Arg-Glu-Arg-Lys-Lys-Arg+Gly-Leu-Tyn-Ala S Arg Lys Lys Arg Gly Leu Tyn Ala Basak et al., 2001
Abz-Arg-Asn-Thr-Pro-Arg-Lys-Lys-Arg-Gly-Leu-Tyn-Ala Abz-Arg-Asn-Thr-Pro-Arg-Lys-Lys-Arg+Gly-Leu-Tyn-Ala S Arg Lys Lys Arg Gly Leu Tyn Ala Basak et al., 2001
Abz-Gly-Gly-Arg-Arg-Thr-Arg-Arg-Glu-Ala-Ile-Tyn-Ala Abz-Gly-Gly-Arg-Arg-Thr-Arg-Arg+Glu-Ala-Ile-Tyn-Ala S Arg Thr Arg Arg Glu Ala Ile Tyn Basak et al., 2001
Abz-Ser-Lys-Lys-Arg-Lys-Arg-Arg-Phe-Leu-Gly-Tyn-Ala Abz-Ser-Lys-Lys-Arg-Lys-Arg-Arg+Phe-Leu-Gly-Tyn-Ala S Arg Lys Arg Arg Phe Leu Gly Tyn Basak et al., 2001
Aerolysin P09167 450-459 Peptide-Arg455+Ser-Peptide S CS Arg Arg Ala Arg Ser Val Asp Gly Remacle et al., 2008
Alpha-toxin Q8GI68 393-402 Peptide-Arg398+Ser-Peptide S CS Arg Gly Lys Arg Ser Val Asp Ser Remacle et al., 2008
Beta-nerve growth factor P01138 116-125 Peptide-Arg121+Ser-Peptide S CS Arg Ser Lys Arg Ser Ser Ser His Remacle et al., 2008
Beta-secretase 1 P56817 40-49 Peptide-Arg45+Glu-Peptide S CS Arg Leu Pro Arg Glu Thr Asp Glu Remacle et al., 2008
Beta-secretase 1 precursor P56817 1-501 Peptide-Arg45+Glu-Peptide P AB Arg Leu Pro Arg Glu Thr Asp Glu Pinnix et al., 2001
Bone morphogenetic protein 1 P13497 115-124 Peptide-Arg120+Ala-Peptide S CS Arg Ser Arg Arg Ala Ala Thr Ser Remacle et al., 2008
bone morphogenetic protein 4 precursor P12644 20-408 peptide-Arg292+Ser-peptide N Arg Ala Lys Arg Ser Pro Lys His Cui et al., 1998
Brain-derived neurotrophic factor P23560 123-132 Peptide-Arg128+His-Peptide S CS Arg Val Arg Arg His Ser Asp Pro Remacle et al., 2008
consensus arginyl bond peptide-Arg-(Xaa)4-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-(Xaa)6-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-Arg+peptide N - NPe Arg Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-Xaa-Xaa-Arg+peptide N Arg Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Lys-(Xaa)4-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Lys-(Xaa)6-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Lys-Xaa-Xaa-Arg+peptide N Lys Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
Cubilin O60494 30-39 Peptide-Arg35+Ser-Peptide S CS Arg Gln Lys Arg Ser Ile Asn Leu Remacle et al., 2008
Diphtheria toxin P00587 214-222 Peptide-Arg218+Ser-Peptide S CS Arg Val Arg Arg Ser Val Gly Ser Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 10 precursor O14672 20-748 peptide-Arg213+Thr-peptide P Arg Lys Lys Arg Thr Thr Ser Ala Anders et al., 2001 20748
Disintegrin and metalloproteinase domain-containing protein 12 O43184 202-211 Peptide-Arg207+Glu-Peptide S CS Arg His Lys Arg Glu Thr Leu Lys Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 17 P78536 209-218 Peptide-Arg214+Arg-Peptide S CS Arg Val Lys Arg Arg Ala Asp Pro Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 19 Q9H013 198-207 Peptide-Arg203+Glu-Peptide S CS Arg Met Lys Arg Glu Asp Leu Asn Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 1a Q60813 215-224 Peptide-Lys220+Pro-Peptide S CS Arg Ser Arg Lys Pro Asp Asp Leu Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 8 P78325 195-204 Peptide-Arg200+Tyr-Peptide S CS Arg Glu Thr Arg Tyr Val Glu Leu Remacle et al., 2008
Ectodysplasin-A Q92838 154-163 Peptide-Arg159+Ser-Peptide S CS Arg Asn Lys Arg Ser Lys Ser Asn Remacle et al., 2008
endothelin-1 precursor P05305 17-212 peptide-Arg92+Ala-peptide P Arg Ser Lys Arg Ala Leu Glu Asn Blais et al., 2002 18005
endothelin-1 precursor P05305 17-212 peptide-Arg52+Cys-peptide P Arg Ser Lys Arg Cys Ser Cys Ser Blais et al., 2002 18009
endothelin-1 precursor P05305 17-212 peptide-Arg168+Ser-peptide P Lys Ile Arg Arg Ser Ser Glu Glu Blais et al., 2002 18010
Envelope glycoprotein Q05320 496-505 Peptide-Arg501+Glu-Peptide S CS Arg Thr Arg Arg Glu Ala Ile Val Remacle et al., 2008
Envelope glycoprotein B P13201 454-464 Peptide-Arg460+Ser-Peptide S CS Arg Thr Lys Arg Ser Thr Asp Gly Remacle et al., 2008
Envelope glycoprotein B P03188 427-436 Peptide-Arg432+Asp-Peptide S CS Arg Arg Arg Arg Asp Ala Gly Asn Remacle et al., 2008
Envelope glycoprotein gp160 Q9WMU9 461-469 Peptide-Arg466+Ala-Peptide S CS Arg Glu Lys Arg Ala Val Gly Leu Remacle et al., 2008
Exotoxin A P11439 299-308 Peptide-Arg304+Gly-Peptide S CS Arg Gln Pro Arg Gly Trp Glu Gln Remacle et al., 2008
Fibrillin-1 P35555 2726-2735 Peptide-Arg2731+Ser-Peptide S CS Arg Lys Arg Arg Ser Thr Asn Glu Remacle et al., 2008
Fibroblast growth factor 23 Q9GZV9 174-183 Peptide-Arg179+Ser-Peptide S CS Arg His Thr Arg Ser Ala Glu Asp Remacle et al., 2008
Furin P09958 70-79 Peptide-Arg75+Ser-Peptide S CS Val Thr Lys Arg Ser Leu Ser Pro Remacle et al., 2008
Furin P09958 102-111 Peptide-Arg107+Asp-Peptide S CS Arg Thr Lys Arg Asp Val Tyr Gln Remacle et al., 2008
Fusion glycoprotein F0 P69353 107-116 Peptide-Arg112+Phe-Peptide S CS Arg His Lys Arg Phe Ala Gly Val Remacle et al., 2008
Fusion glycoprotein F0 Q8V1Q2 111-120 Peptide-Arg116+Leu-Peptide S CS Arg Gln Lys Arg Leu Ile Gly Ala Remacle et al., 2008
Fusion glycoprotein F0 Q84193 104-113 Peptide-Arg109+Phe-Peptide S CS Arg Thr Lys Arg Phe Phe Gly Gly Remacle et al., 2008
Gastrin P01350 53-62 Peptide-Arg58+Gln-Peptide S CS His His Arg Arg Gln Leu Gly Pro Remacle et al., 2008
Genome polyprotein P29990 200-209 Peptide-Arg205+Ser-Peptide S CS Arg Gln Lys Arg Ser Val Ala Leu Remacle et al., 2008
Genome polyprotein P06935 210-219 Peptide-Arg215+Ser-Peptide S CS Arg Ser Arg Arg Ser Leu Thr Val Remacle et al., 2008
Hemagglutinin O56140 341-350 Peptide-Arg346+Gly-Peptide S CS Arg Lys Lys Arg Gly Leu Phe Gly Remacle et al., 2008
Hepatocyte growth factor receptor P08581 302-311 Peptide-Arg307+Ser-Peptide S CS Arg Lys Lys Arg Ser Thr Lys Lys Remacle et al., 2008
Hepatocyte growth factor receptor P14210 489-498 Peptide-Arg494+Val-Peptide S CS Lys Gln Leu Arg Val Val Asn Gly Remacle et al., 2008
Insulin receptor P06213 757-766 Peptide-Arg762+Ser-Peptide S CS Arg Lys Arg Arg Ser Leu Gly Asp Remacle et al., 2008
Insulin-like growth factor I P05019 114-123 Peptide-Arg119+Ser-Peptide S CS Lys Ser Ala Arg Ser Val Arg Ala Remacle et al., 2008
Insulin-like growth factor II P01344 87-96 Peptide-Arg92+Asp-Peptide S CS Lys Ser Glu Arg Asp Val Ser Thr Remacle et al., 2008
Integrin alpha-3 P26006 870-879 Peptide-Arg875+Gln-Peptide S CS Arg Arg Arg Arg Gln Leu Asp Pro Remacle et al., 2008
Integrin alpha-4 P13612 586-595 Peptide-Arg591+Ser-Peptide S CS Ile Ser Lys Arg Ser Thr Glu Glu Remacle et al., 2008
Integrin alpha-5 P08648 889-898 Peptide-Arg894+Glu-Peptide S CS Gln Gln Lys Arg Glu Ala Pro Ser Remacle et al., 2008
Integrin alpha-6 P23229 936-945 Peptide-Arg941+Glu-Peptide S CS Arg Lys Lys Arg Glu Ile Thr Glu Remacle et al., 2008
Integrin alpha-7 Q13683 953-962 Peptide-Arg958+Glu-Peptide S CS Arg Arg Arg Arg Glu Leu Glu Pro Remacle et al., 2008
Integrin alpha-8 P53708 901-910 Peptide-Arg906+Asp-Peptide S CS Val Arg Lys Arg Asp Val His Val Remacle et al., 2008
Integrin alpha-IIb P08514 885-894 Peptide-Arg890+Gln-Peptide S CS Arg Asp Arg Arg Gln Ile Phe Leu Remacle et al., 2008
Integrin alpha-V P06756 885-894 Peptide-Arg890+Asp-Peptide S CS Ile Thr Lys Arg Asp Leu Ala Leu Remacle et al., 2008
Interstitial collagenase propeptide P03956 86-95 Peptide-Arg91+Cys-Peptide S CS Lys Gln Pro Arg Cys Gly Val Pro Remacle et al., 2008
Left-right determination factor 2 O00292 72-81 Peptide-Arg77+Phe-Peptide S CS Arg Gly Lys Arg Phe Ser Gln Ser Remacle et al., 2008
Matrix metalloproteinase-14 precursor P50281 106-115 Peptide-Arg111+Tyr-Peptide S CS Arg Arg Lys Arg Tyr Ala Ile Gln Remacle et al., 2008
Matrix metalloproteinase-15 O54732 122-131 Peptide-Arg127+Tyr-Peptide S CS Arg Arg Lys Arg Tyr Thr Leu Thr Remacle et al., 2008
Matrix metalloproteinase-21 Q8N119 139-148 Peptide-Arg144+Ser-Peptide S CS Arg Ser Arg Arg Ser Pro Arg Ala Remacle et al., 2008
Matrix metalloproteinase-24 Q9Y5R2 150-159 Peptide-Arg155+Tyr-Peptide S CS Arg Asn Lys Arg Tyr Ala Leu Thr Remacle et al., 2008
Meprin A subunit alpha Q16819 648-657 Peptide-Arg653+Ser-Peptide S CS Arg Gln Lys Arg Ser Val Glu Asn Remacle et al., 2008
Natriuretic peptides B P16860 97-106 Peptide-Arg102+Ser-Peptide S CS Arg Ala Pro Arg Ser Pro Lys Met Remacle et al., 2008
Neuroendocrine protein 7B2 P05408 176-185 Peptide-Arg181+Ser-Peptide S CS Arg Lys Arg Arg Ser Val Asn Pro Remacle et al., 2008
Neurogenic locus notch homolog protein 1 P46531 1659-1668 Peptide-Arg1664+Glu-Peptide S CS Arg Arg Arg Arg Glu Leu Asp Pro Remacle et al., 2008
Neurotrophin-3 P20783 133-142 Peptide-Arg138+Tyr-Peptide S CS Arg Arg Lys Arg Tyr Ala Glu His Remacle et al., 2008
Neurotrophin-4 P34130 75-84 Peptide-Arg80+Gly-Peptide S CS Arg Ser Arg Arg Gly Val Ser Glu Remacle et al., 2008
Neutrophil collagenase P22894 85-94 Peptide-Arg90+Cys-Peptide S CS Lys Lys Pro Arg Cys Gly Val Pro Remacle et al., 2008
Pancreatic hormone P01298 63-72 Peptide-Arg68+His-Peptide S CS Tyr Gly Lys Arg His Lys Glu Asp Remacle et al., 2008
parathyroid hormone precursor P01270 26-115 Lys-Ser-Val-Lys-Lys-Arg+Ser-Val-Ser-Glu-Ile-Gln-Leu P Val Lys Lys Arg Ser Val Ser Glu Seidah & Chretien, 2004
Parathyroid hormone-related protein P12272 31-40 Peptide-Arg36+Ala-Peptide S CS Arg Leu Lys Arg Ala Val Ser Glu Remacle et al., 2008
platelet-derived growth factor B chain P01127 21-241 peptide-Arg81+Ser-peptide P Arg Gly Arg Arg Ser Leu Gly Ser Siegfried et al., 2005 19139
Platelet-derived growth factor C Q9NRA1 229-238 Peptide-Arg234+Val-Peptide S CS Arg Lys Ser Arg Val Val Asp Leu Remacle et al., 2008
Platelet-derived growth factor D Q9GZP0 252-261 Peptide-Lys257+Val-Peptide S CS Arg Lys Ser Lys Val Asp Leu Asp Remacle et al., 2008
Platelet-derived growth factor subunit A P04085 81-90 Peptide-Arg86+Ser-Peptide S CS Arg Arg Lys Arg Ser Ile Glu Glu Remacle et al., 2008
PMCH pro-melanin-concentrating hormone P14200 1-165 peptide-Lys129+Arg-peptide P Thr Gln Glu Lys Arg Glu Ile Gly Viale et al., 1999 25648
pro-melanin-concentrating hormone P14200 22-165 peptide-Arg146+Asp-peptide P Ile Gly Arg Arg Asp Phe Asp Met Viale et al., 1999
Pro-opiomelanocortin P01189 173-182 Peptide-Arg178+Glu-Peptide S CS Glu Phe Lys Arg Glu Leu Thr Gly Remacle et al., 2008
Pro-opiomelanocortin P01189 150-159 Peptide-Arg155+Pro-Peptide S CS Lys Lys Arg Arg Pro Val Lys Val Remacle et al., 2008
Pro-opiomelanocortin P01189 231-240 Peptide-Arg236+Tyr-Peptide S CS Lys Asp Lys Arg Tyr Gly Gly Phe Remacle et al., 2008
Proenkephalin-A P01210 137-146 Peptide-Lys142+Asp-Peptide S CS Phe Met Lys Lys Asp Ala Glu Glu Remacle et al., 2008
Proenkephalin-A P01210 190-199 Peptide-Arg195+Ser-Peptide S CS Gly Leu Lys Arg Ser Pro Gln Leu Remacle et al., 2008
Proheparin-binding EGF-like growth factor Q99075 57-66 Peptide-Arg62+Asp-Peptide S CS Arg Lys Val Arg Asp Leu Gln Glu Remacle et al., 2008
Proliferation-inducing ligand APRIL Q8NFH7 99-108 Peptide-Arg104+Ala-Peptide S CS Arg Lys Arg Arg Ala Val Leu Thr Remacle et al., 2008
Prolow-density lipoprotein receptor-related protein 1 Q07954 3938-3947 Peptide-Arg3943+Gln-Peptide S CS Arg His Arg Arg Gln Ile Asp Arg Remacle et al., 2008
proprotein convertase 4 P29121 27-655 Tyr-Glu-Thr-Leu-Arg-Arg-Arg-Val-Lys-Arg+Ser-Leu-Val-Val-Pro-Thr-Asp P Arg Val Lys Arg Ser Leu Val Val Seidah & Chretien, 2004
Protective antigen P13423 191-200 Peptide-Arg196+Ser-Peptide S CS Arg Lys Lys Arg Ser Thr Ser Ala Remacle et al., 2008
Semaphorin-3A Q14563 550-559 Peptide-Arg555+Gln-Peptide S CS Arg Thr Arg Arg Gln Asp Ile Arg Remacle et al., 2008
Serum albumin P02768 19-28 Peptide-Arg24+Asp-Peptide S CS Val Phe Arg Arg Asp Ala His Lys Remacle et al., 2008
Shiga toxin 1 subunit A C8UEJ9 268-277 Peptide-Arg273+Met-Peptide S CS Arg Val Ala Arg Met Ala Ser Asp Remacle et al., 2008
Sortilin-related receptor Q92673 76-85 Peptide-Arg81+Ser-Peptide S CS Arg Arg Lys Arg Ser Ala Ala Leu Remacle et al., 2008
Spike glycoprotein P11223 532-541 Peptide-Arg537+Ser-Peptide S CS Arg Phe Arg Arg Ser Ile Thr Glu Remacle et al., 2008
Stromelysin-3 P24347 92-101 Peptide-Arg97+Phe-Peptide S CS Arg Gln Lys Arg Phe Val Leu Ser Remacle et al., 2008
Structural polyprotein P03316 323-332 Peptide-Arg328+Ser-Peptide S CS Arg Ser Lys Arg Ser Val Ile Asp Remacle et al., 2008
Transforming growth factor beta-1 P01137 273-282 Peptide-Arg278+Ala-Peptide S CS Arg His Arg Arg Ala Leu Asp Thr Remacle et al., 2008
Tumor necrosis factor ligand superfamily member 13 O75888 99-100 Peptide-Arg104+Ala-Peptide S CS Arg Lys Arg Arg Ala Val Leu Thr Remacle et al., 2008
Tumor necrosis factor ligand superfamily member 13b Q9Y275 128-137 Peptide-Arg133+Ala-Peptide S CS Arg Asn Lys Arg Ala Val Gln Gly Remacle et al., 2008
vascular endothelial growth factor C precursor P49767 32-419 peptide-Arg227+Ser-peptide P Ile Ile Arg Arg Ser Leu Pro Ala Siegfried et al., 2003 18114
vascular endothelial growth factor D precursor O43915 22-354 peptide-Arg205+Ser-peptide P Ile Ile Arg Arg Ser Ile Gln Ile McColl et al., 2007
Vitamin K-dependent protein C P04070 194-203 Peptide-Arg199+Asp-Peptide S CS His Leu Lys Arg Asp Thr Glu Asp Remacle et al., 2008
von Willebrand factor P04275 758-767 Peptide-Arg763+Ser-Peptide S CS Arg Ser Lys Arg Ser Leu Ser Cys Remacle et al., 2008
Zona pellucida sperm-binding protein 3 P21754 347-356 Peptide-Arg352+His-Peptide S CS Arg Asn Arg Arg His Val Thr Glu Remacle et al., 2008

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