$VAR1 = undef;

Summary for peptidase S08.077: PCSK7 peptidase

Names
MEROPS Name	PCSK7 peptidase
Other names	PC7, proprotein convertase 8, PC8, LPC, lymphoma proprotein convertase, proprotein convertase subtilisin kexin 7, PCSK7 g.p. (Homo sapiens), proprotein convertase 7, proprotein convertase subtilisin/kexin type 7

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.077
Holotype	PCSK7 peptidase (Rattus norvegicus), Uniprot accession Q62849 (peptidase unit: 155-458), MERNUM MER0002264
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00364
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (7 cleavages)
Activity status	human: active (Seidah & Chretien, 2004) mouse: active (by similarity to human)
Physiology	Processes various preproteins by cleavage at paired basic amino acids.
Other databases	TREEFAM	http://www.treefam.org/family/TF314277
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	R/-/KR/Rs/vla/-/- (based on 116 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	5	0	0	7	4	13	9
Pro	0	0	7	0	2	4	3	11
Ala	0	5	3	0	10	20	4	10
Val	4	5	1	0	3	25	3	7
Leu	0	5	1	0	1	22	8	11
Ile	5	3	0	0	0	8	6	1
Met	0	2	0	0	1	0	0	2
Phe	1	3	0	0	7	2	2	1
Tyr	1	0	0	0	6	0	1	0
Trp	0	0	0	0	0	1	0	0
Ser	0	13	2	0	34	5	13	9
Thr	1	8	2	0	1	11	6	6
Cys	0	0	0	0	4	0	1	1
Asn	0	4	0	0	0	0	5	5
Gln	1	11	0	0	5	0	5	3
Asp	0	2	0	0	10	4	14	8
Glu	1	2	2	0	11	1	13	15
Lys	9	23	54	4	0	2	4	3
Arg	85	12	38	112	2	0	2	2
His	2	6	0	0	5	0	2	3