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Literature for peptidase S08.077: PCSK7 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Sachan,V., Susan-Resiga,D., Lam,K. and Seidah,N.G.
    The Biology and Clinical Implications of PCSK7
    Endocr Rev PubMed  Europe PubMed DOI  K  V
    2. 2023
  2. Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.
    Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway
    Adv Protein Chem Struct Biol133, 1-54. PubMed  Europe PubMed DOI  V
    3. 2020
  3. Durand,L., Duval,S., Evagelidis,A., Guillemot,J., Dianati,V., Sikorska,E., Schu,P., Day,R. and Seidah,N.G.
    The motif ExExxxL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity
    J Biol Chem295, 2068-2083. PubMed  Europe PubMed DOI
    4. 2019
  4. Dongiovanni,P., Meroni,M., Baselli,G., Mancina,R.M., Ruscica,M., Longo,M., Rametta,R., Cespiati,A., Pelusi,S., Ferri,N., Ranzani,V., Nobili,V., Pihlajamaki,J., Fracanzani,A.L., Badiali,S., Petta,S., Fargion,S., Romeo,S., Kozlitina,J. and Valenti,L.
    PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients
    J Lipid Res60, 1144-1153. PubMed  Europe PubMed DOI  M
    5. 2017
  5. Anyetei-Anum,E.N., Blum,A., Seidah,N.G. and Beinfeld,M.C.
    Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain
    Biochem Biophys Res Commun482, 1190-1193. PubMed  Europe PubMed DOI
    6. 2016
  6. Demasi,M.A., de S Molina,E., Bowman-Colin,C., Lojudice,F.H., Muras,A. and Sogayar,M.C.
    Enhanced proteolytic processing of recombinant human coagulation factor VIII B-domain variants by recombinant furins
    Mol Biotechnol58, 404-414. PubMed  Europe PubMed DOI
  7. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
    [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
    Postepy Biochem62, 472-481. PubMed  Europe PubMed  V
  8. Pelucchi,S., Galimberti,S., Greni,F., Rametta,R., Mariani,R., Pelloni,I., Girelli,D., Busti,F., Ravasi,G., Valsecchi,M.G., Valenti,L. and Piperno,A.
    Proprotein convertase 7 rs236918 associated with liver fibrosis in Italian patients with HFE-related hemochromatosis
    J Gastroenterol Hepatol31, 1342-1348. PubMed  Europe PubMed DOI  M
    9. 2015
  9. Bessonnard,S., Mesnard,D. and Constam,D.B.
    PC7 and the related proteases furin and pace4 regulate E-cadherin function during blastocyst formation
    J Cell Biol210, 1185-1197. PubMed  Europe PubMed DOI
    10. 2013
  10. Guillemot,J., Canuel,M., Essalmani,R., Prat,A. and Seidah,N.G.
    Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin
    Hepatology57, 2514-2524. PubMed  Europe PubMed DOI  P
  11. Schwienbacher,C., Serafin,A., Zanon,A., Pramstaller,P.P., Pichler,I. and Hicks,A.A.
    Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis
    Hepatology58, 1860-1861. PubMed  Europe PubMed DOI
  12. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem288, 21473-21481. PubMed  Europe PubMed DOI  V
  13. Turpeinen,H., Oksanen,A., Kivinen,V., Kukkurainen,S., Uusimaki,A., Ramet,M., Parikka,M., Hytonen,V.P., Nykter,M. and Pesu,M.
    Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor beta1a (TGFbeta1a)
    J Biol Chem288, 36610-36623. PubMed  Europe PubMed DOI
  14. Turpeinen,H., Ortutay,Z. and Pesu,M.
    Genetics of the first seven proprotein convertase enzymes in health and disease
    Curr Genomics14, 453-467. PubMed  Europe PubMed DOI  V
    15. 2012
  15. Declercq,J., Meulemans,S., Plets,E. and Creemers,J.W.
    Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif
    J Biol Chem287, 9052-9060. PubMed  Europe PubMed DOI
  16. Seidah,N.G.
    Proprotein convertase 7
    [ISSN:978-0-12-407742-3]3, 3310-3314. DOI
  17. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov11, 367-383. PubMed  Europe PubMed DOI  V
  18. Senturker,S., Thomas,J.T., Mateshaytis,J. and Moos,M., Jr.
    A homolog of subtilisin-like proprotein convertase 7 is essential to anterior neural development in Xenopus
    PLoS ONE7, e39380-e39380. PubMed  Europe PubMed DOI
    19. 2011
  19. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
    In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
    Methods Mol Biol768, 127-153. PubMed  Europe PubMed DOI  A
  20. Rousselet,E., Benjannet,S., Hamelin,J., Canuel,M. and Seidah,N.G.
    The proprotein convertase PC7: unique zymogen activation and trafficking pathways
    J Biol Chem286, 2728-2738. PubMed  Europe PubMed DOI
  21. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol768, 23-57. PubMed  Europe PubMed DOI  V
  22. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci1220, 149-161. PubMed  Europe PubMed DOI  V
    23. 2010
  23. Leonhardt,R.M., Fiegl,D., Rufer,E., Karger,A., Bettin,B. and Knittler,M.R.
    Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7
    J Immunol184, 2985-2998. PubMed  Europe PubMed DOI
  24. Tian,S. and Jianhua,W.
    Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
    Int J Biol Sci6, 89-95. PubMed  Europe PubMed  P  I
    25. 2009
  25. Longpre,J.M., McCulloch,D.R., Koo,B.H., Alexander,J.P., Apte,S.S. and Leduc,R.
    Characterization of proADAMTS5 processing by proprotein convertases
    Int J Biochem Cell Biol41, 1116-1126. PubMed  Europe PubMed DOI
  26. Nelsen,S.M. and Christian,J.L.
    Site-specific cleavage of BMP4 by furin, PC6, and PC7
    J Biol Chem284, 27157-27166. PubMed  Europe PubMed DOI
  27. Rholam,M. and Fahy,C.
    Processing of peptide and hormone precursors at the dibasic cleavage sites
    Cell Mol Life Sci66, 2075-2091. PubMed  Europe PubMed DOI
    28. 2008
  28. Creemers,J.W. and Khatib,A.M.
    Knock-out mouse models of proprotein convertases: unique functions or redundancy?
    Front Biosci13, 4960-4971. PubMed  Europe PubMed DOI  K
  29. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.
    Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
    J Biol Chem283, 20897-20906. PubMed  Europe PubMed DOI  P
    30. 2007
  30. Fugere,M., Appel,J., Houghten,R.A., Lindberg,I. and Day,R.
    Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences
    Mol Pharmacol71, 323-332. PubMed  Europe PubMed DOI  I
    31. 2006
  31. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    32. 2005
  32. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
    Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
    J Mol Biol345, 211-227. PubMed  Europe PubMed DOI  S
    33. 2004
  33. Seidah,N.G. and Chretien,M.
    Proprotein convertase 7
    [ISSN:0-12-079610-4]2, 1877-1880.  V
    34. 2003
  34. Siegfried,G., Basak,A., Cromlish,J.A., Benjannet,S., Marcinkiewicz,J., Chretien,M., Seidah,N.G. and Khatib,A.M.
    The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
    J Clin Invest111, 1723-1732. PubMed  Europe PubMed DOI
  35. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
    Curbing activation: proprotein convertases in homeostasis and pathology
    FASEB J17, 1215-1227. PubMed  Europe PubMed DOI  K
    36. 2002
  36. Blais,V., Fugere,M., Denault,J.B., Klarskov,K., Day,R. and Leduc,R.
    Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family
    FEBS Lett524, 43-48. PubMed  Europe PubMed DOI
  37. Fugere,M. and Day,R.
    Inhibitors of the subtilase-like pro-protein convertases (SPCs)
    Curr Pharm Des8, 549-562. PubMed  Europe PubMed DOI  V  I
  38. Seidah,N.G. and Prat,A.
    Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    Essays Biochem38, 79-94. PubMed  Europe PubMed
    39. 2000
  39. [YEAR:21-3-2000]Bhattacharjya,S., Xu,P., Zhong,M., Chretien,M., Seidah,N.G. and Ni,F.
    Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7
    Biochemistry39, 2868-2877. PubMed  Europe PubMed DOI
  40. [YEAR:8-12-2000]Creemers,J.W., van de Loo,J.W., Plets,E., Hendershot,L.M. and Van de Ven,W.J.
    Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation
    J Biol Chem275, 38842-38847. PubMed  Europe PubMed DOI
  41. [YEAR:15-12-2000]van de Loo,J.W., Teuchert,M., Pauli,I., Plets,E., Van de Ven,W.J. and Creemers,J.W.
    Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization
    Biochem J352, 827-833. PubMed  Europe PubMed DOI
    42. 1999
  42. Canaff,L., Bennett,H.P., Hou,Y., Seidah,N.G. and Hendy,G.N.
    Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3
    Endocrinology140, 3633-3642. PubMed  Europe PubMed DOI
  43. Lopez-Perez,E., Seidah,N.G. and Checler,F.
    Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: Evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway
    J Neurochem73, 2056-2062. PubMed  Europe PubMed
    44. 1998
  44. [YEAR:1-12-1998]Goodge,K.A., Thomas,R.J., Martin,T.J. and Gillespie,M.T.
    Gene organization and alternative splicing of human prohormone convertase PC8
    Biochem J336, 353-359. PubMed  Europe PubMed
    45. 1997
  45. Decroly,E., Benjannet,S., Savaria,D. and Seidah,N.G.
    Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160
    FEBS Lett405, 68-72. PubMed  Europe PubMed DOI
  46. Munzer,J.S., Basak,A., Zhong,M., Mamarbachi,A., Hamelin,J., Savaria,D., Lazure,C., Hendy,G.N., Benjannet,S., Chretien,M. and Seidah,N.G.
    In vitro characterization of the novel proprotein convertase PC7
    J Biol Chem272, 19672-19681. PubMed  Europe PubMed DOI
  47. [YEAR:24-10-1997]van de Loo,J.W., Creemers,J.W., Bright,N.A., Young,B.D., Roebroek,A.J. and Van de Ven,W.J.
    Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase
    J Biol Chem272, 27116-27123. PubMed  Europe PubMed DOI
    48. 1996
  48. Bruzzaniti,A., Goodge,K., Jay,P., Taviaux,S.A., Lam,M.H.C., Berta,P., Martin,T.J., Moseley,J.M. and Gillespie,M.T.
    PC8, a new member of the convertase family
    Biochem J314, 727-731. PubMed  Europe PubMed
  49. Constam,D.B., Calfon,M. and Robertson,E.J.
    SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis
    J Cell Biol134, 181-191. PubMed  Europe PubMed DOI
  50. Meerabux,J., Yaspo,M.L., Roebroek,A.J., Van de Ven,W.J., Lister,T.A. and Young,B.D.
    A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas
    Cancer Res56, 448-451. PubMed  Europe PubMed
  51. Seidah,N.G., Hamelin,J., Mamarbachi,M., Dong,W., Tardos,H., Mbikay,M., Chretien,M. and Day,R.
    cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases
    Proc Natl Acad Sci U S A93, 3388-3393. PubMed  Europe PubMed DOI

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