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Literature for peptidase S08.077: PCSK7 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Sachan,V., Susan-Resiga,D., Lam,K. and Seidah,N.G.<br>The Biology and Clinical Implications of PCSK7<br>Endocr Rev (2024) PubMed  Europe PubMed DOI  K  V
    2. 2023
  2. Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.<br>Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway<br>Adv Protein Chem Struct Biol (2023) 133, 1-54. PubMed  Europe PubMed DOI  V
    3. 2020
  3. Durand,L., Duval,S., Evagelidis,A., Guillemot,J., Dianati,V., Sikorska,E., Schu,P., Day,R. and Seidah,N.G.<br>The motif ExExxxL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity<br>J Biol Chem (2020) 295, 2068-2083. PubMed  Europe PubMed DOI
    4. 2019
  4. Dongiovanni,P., Meroni,M., Baselli,G., Mancina,R.M., Ruscica,M., Longo,M., Rametta,R., Cespiati,A., Pelusi,S., Ferri,N., Ranzani,V., Nobili,V., Pihlajamaki,J., Fracanzani,A.L., Badiali,S., Petta,S., Fargion,S., Romeo,S., Kozlitina,J. and Valenti,L.<br>PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients<br>J Lipid Res (2019) 60, 1144-1153. PubMed  Europe PubMed DOI  M
    5. 2017
  5. Anyetei-Anum,E.N., Blum,A., Seidah,N.G. and Beinfeld,M.C.<br>Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain<br>Biochem Biophys Res Commun (2017) 482, 1190-1193. PubMed  Europe PubMed DOI
    6. 2016
  6. Demasi,M.A., de S Molina,E., Bowman-Colin,C., Lojudice,F.H., Muras,A. and Sogayar,M.C.<br>Enhanced proteolytic processing of recombinant human coagulation factor VIII B-domain variants by recombinant furins<br>Mol Biotechnol (2016) 58, 404-414. PubMed  Europe PubMed DOI
  7. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.<br>[Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]<br>Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
  8. Pelucchi,S., Galimberti,S., Greni,F., Rametta,R., Mariani,R., Pelloni,I., Girelli,D., Busti,F., Ravasi,G., Valsecchi,M.G., Valenti,L. and Piperno,A.<br>Proprotein convertase 7 rs236918 associated with liver fibrosis in Italian patients with HFE-related hemochromatosis<br>J Gastroenterol Hepatol (2016) 31, 1342-1348. PubMed  Europe PubMed DOI  M
    9. 2015
  9. Bessonnard,S., Mesnard,D. and Constam,D.B.<br>PC7 and the related proteases furin and pace4 regulate E-cadherin function during blastocyst formation<br>J Cell Biol (2015) 210, 1185-1197. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2013
  10. Guillemot,J., Canuel,M., Essalmani,R., Prat,A. and Seidah,N.G.<br>Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin<br>Hepatology (2013) 57, 2514-2524. PubMed  Europe PubMed DOI  P
  11. Schwienbacher,C., Serafin,A., Zanon,A., Pramstaller,P.P., Pichler,I. and Hicks,A.A.<br>Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis<br>Hepatology (2013) 58, 1860-1861. PubMed  Europe PubMed DOI
  12. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.<br>The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions<br>J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
  13. Turpeinen,H., Ortutay,Z. and Pesu,M.<br>Genetics of the first seven proprotein convertase enzymes in health and disease<br>Curr Genomics (2013) 14, 453-467. PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Turpeinen,H., Oksanen,A., Kivinen,V., Kukkurainen,S., Uusimaki,A., Ramet,M., Parikka,M., Hytonen,V.P., Nykter,M. and Pesu,M.<br>Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor beta1a (TGFbeta1a)<br>J Biol Chem (2013) 288, 36610-36623. PubMed  Europe PubMed DOI
    15. 2012
  15. Declercq,J., Meulemans,S., Plets,E. and Creemers,J.W.<br>Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif<br>J Biol Chem (2012) 287, 9052-9060. PubMed  Europe PubMed DOI
  16. Seidah,N.G. and Prat,A.<br>The biology and therapeutic targeting of the proprotein convertases<br>Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  17. Seidah,N.G.<br>Proprotein convertase 7<br>[ISSN:978-0-12-407742-3] (2012) 3, 3310-3314. DOI
  18. Senturker,S., Thomas,J.T., Mateshaytis,J. and Moos,M., Jr.<br>A homolog of subtilisin-like proprotein convertase 7 is essential to anterior neural development in Xenopus<br>PLoS ONE (2012) 7, e39380-e39380. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2011
  19. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.<br>In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies<br>Methods Mol Biol (2011) 768, 127-153. PubMed  Europe PubMed DOI  A
  20. Rousselet,E., Benjannet,S., Hamelin,J., Canuel,M. and Seidah,N.G.<br>The proprotein convertase PC7: unique zymogen activation and trafficking pathways<br>J Biol Chem (2011) 286, 2728-2738. PubMed  Europe PubMed DOI
  21. Seidah,N.G.<br>What lies ahead for the proprotein convertases?<br>Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  22. Seidah,N.G.<br>The proprotein convertases, 20 years later<br>Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
    23. 2010
  23. Leonhardt,R.M., Fiegl,D., Rufer,E., Karger,A., Bettin,B. and Knittler,M.R.<br>Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7<br>J Immunol (2010) 184, 2985-2998. PubMed  Europe PubMed DOI
  24. Tian,S. and Jianhua,W.<br>Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors<br>Int J Biol Sci (2010) 6, 89-95. PubMed  Europe PubMed  PMC  EPMC  P  I
    25. 2009
  25. Longpre,J.M., McCulloch,D.R., Koo,B.H., Alexander,J.P., Apte,S.S. and Leduc,R.<br>Characterization of proADAMTS5 processing by proprotein convertases<br>Int J Biochem Cell Biol (2009) 41, 1116-1126. PubMed  Europe PubMed DOI
  26. Nelsen,S.M. and Christian,J.L.<br>Site-specific cleavage of BMP4 by furin, PC6, and PC7<br>J Biol Chem (2009) 284, 27157-27166. PubMed  Europe PubMed DOI
  27. Rholam,M. and Fahy,C.<br>Processing of peptide and hormone precursors at the dibasic cleavage sites<br>Cell Mol Life Sci (2009) 66, 2075-2091. PubMed  Europe PubMed DOI
    28. 2008
  28. Creemers,J.W. and Khatib,A.M.<br>Knock-out mouse models of proprotein convertases: unique functions or redundancy?<br>Front Biosci (2008) 13, 4960-4971. PubMed  Europe PubMed DOI  K
  29. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.<br>Substrate cleavage analysis of furin and related proprotein convertases. A comparative study<br>J Biol Chem (2008) 283, 20897-20906. PubMed  Europe PubMed DOI  PMC  EPMC  P
    30. 2007
  30. Fugere,M., Appel,J., Houghten,R.A., Lindberg,I. and Day,R.<br>Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences<br>Mol Pharmacol (2007) 71, 323-332. PubMed  Europe PubMed DOI  I
    31. 2006
  31. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>Proprotein convertases: lessons from knockouts<br>FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    32. 2005
  32. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.<br>Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity<br>J Mol Biol (14-1-2005) 345, 211-227. PubMed  Europe PubMed DOI  S
    33. 2004
  33. Seidah,N.G. and Chretien,M.<br>Proprotein convertase 7<br>[ISSN:0-12-079610-4] (2004) 2, 1877-1880.  V
    34. 2003
  34. Siegfried,G., Basak,A., Cromlish,J.A., Benjannet,S., Marcinkiewicz,J., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis<br>J Clin Invest (2003) 111, 1723-1732. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.<br>Curbing activation: proprotein convertases in homeostasis and pathology<br>FASEB J (2003) 17, 1215-1227. PubMed  Europe PubMed DOI  K
    36. 2002
  36. Blais,V., Fugere,M., Denault,J.B., Klarskov,K., Day,R. and Leduc,R.<br>Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family<br>FEBS Lett (2002) 524, 43-48. PubMed  Europe PubMed DOI
  37. Fugere,M. and Day,R.<br>Inhibitors of the subtilase-like pro-protein convertases (SPCs)<br>Curr Pharm Des (2002) 8, 549-562. PubMed  Europe PubMed DOI  V  I
  38. Seidah,N.G. and Prat,A.<br>Precursor convertases in the secretory pathway, cytosol and extracellular milieu<br>Essays Biochem (2002) 38, 79-94. PubMed  Europe PubMed
    39. 2000
  39. [YEAR:21-3-2000]Bhattacharjya,S., Xu,P., Zhong,M., Chretien,M., Seidah,N.G. and Ni,F.<br>Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7<br>Biochemistry (21-3-2000) 39, 2868-2877. PubMed  Europe PubMed DOI
  40. [YEAR:8-12-2000]Creemers,J.W., van de Loo,J.W., Plets,E., Hendershot,L.M. and Van de Ven,W.J.<br>Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation<br>J Biol Chem (8-12-2000) 275, 38842-38847. PubMed  Europe PubMed DOI
  41. [YEAR:15-12-2000]van de Loo,J.W., Teuchert,M., Pauli,I., Plets,E., Van de Ven,W.J. and Creemers,J.W.<br>Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization<br>Biochem J (15-12-2000) 352, 827-833. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 1999
  42. Canaff,L., Bennett,H.P., Hou,Y., Seidah,N.G. and Hendy,G.N.<br>Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3<br>Endocrinology (1999) 140, 3633-3642. PubMed  Europe PubMed DOI
  43. Lopez-Perez,E., Seidah,N.G. and Checler,F.<br>Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: Evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway<br>J Neurochem (1999) 73, 2056-2062. PubMed  Europe PubMed
    44. 1998
  44. [YEAR:1-12-1998]Goodge,K.A., Thomas,R.J., Martin,T.J. and Gillespie,M.T.<br>Gene organization and alternative splicing of human prohormone convertase PC8<br>Biochem J (1-12-1998) 336, 353-359. PubMed  Europe PubMed  PMC  EPMC
    45. 1997
  45. Decroly,E., Benjannet,S., Savaria,D. and Seidah,N.G.<br>Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160<br>FEBS Lett (1997) 405, 68-72. PubMed  Europe PubMed DOI
  46. Munzer,J.S., Basak,A., Zhong,M., Mamarbachi,A., Hamelin,J., Savaria,D., Lazure,C., Hendy,G.N., Benjannet,S., Chretien,M. and Seidah,N.G.<br>In vitro characterization of the novel proprotein convertase PC7<br>J Biol Chem (1997) 272, 19672-19681. PubMed  Europe PubMed DOI
  47. [YEAR:24-10-1997]van de Loo,J.W., Creemers,J.W., Bright,N.A., Young,B.D., Roebroek,A.J. and Van de Ven,W.J.<br>Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase<br>J Biol Chem (24-10-1997) 272, 27116-27123. PubMed  Europe PubMed DOI
    48. 1996
  48. Bruzzaniti,A., Goodge,K., Jay,P., Taviaux,S.A., Lam,M.H.C., Berta,P., Martin,T.J., Moseley,J.M. and Gillespie,M.T.<br>PC8, a new member of the convertase family<br>Biochem J (1996) 314, 727-731. PubMed  Europe PubMed
  49. Constam,D.B., Calfon,M. and Robertson,E.J.<br>SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis<br>J Cell Biol (1996) 134, 181-191. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Meerabux,J., Yaspo,M.L., Roebroek,A.J., Van de Ven,W.J., Lister,T.A. and Young,B.D.<br>A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas<br>Cancer Res (1996) 56, 448-451. PubMed  Europe PubMed
  51. Seidah,N.G., Hamelin,J., Mamarbachi,M., Dong,W., Tardos,H., Mbikay,M., Chretien,M. and Day,R.<br>cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases<br>Proc Natl Acad Sci U S A (1996) 93, 3388-3393. PubMed  Europe PubMed DOI  PMC  EPMC

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