Searches of the MEROPS database
Display Known Cleavages for a Protein
Please enter a UniProt accession (eg P05067):
Sequence P02768
,
Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 18 |
unknown peptidase |
1-609 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 22 |
unknown peptidase |
1-609 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 24 |
epralysin |
18-28 |
N |
|
|
Kim et al., 1997 |
| 24 |
kallikrein-related peptidase 4 |
1-609 |
P |
|
CS |
Matsumura et al., 2005 |
| 24 |
furin |
19-609 |
P |
|
|
Brennan & Nakayama, 1994 |
| 24 |
PCSK1 peptidase |
19-609 |
P |
|
|
Rufaut et al., 1993 |
| 24 |
PCSK4 peptidase |
19-28 |
N |
|
CS |
Remacle et al., 2008 |
| 24 |
PCSK6 peptidase |
19-28 |
N |
|
CS |
Remacle et al., 2008 |
| 24 |
PCSK5 peptidase |
19-28 |
N |
|
CS |
Remacle et al., 2008 |
| 24 |
PCSK7 peptidase |
19-28 |
N |
|
CS |
Remacle et al., 2008 |
| 108 |
chymase (Homo sapiens-type) |
25-609 |
P |
|
|
Raymond et al., 2003 |
| 169 |
BACE2 g.p. (Homo sapiens) |
166-174 |
N |
|
MS |
Kim et al., 2002 |
| 170 |
BACE2 g.p. (Homo sapiens) |
166-174 |
N |
|
MS |
Kim et al., 2002 |
| 172 |
BACE2 g.p. (Homo sapiens) |
166-174 |
N |
|
MS |
Kim et al., 2002 |
| 172 |
meprin beta subunit |
166-174 |
N |
|
|
Bertenshaw et al., 2001 |
| 242 |
matrix metallopeptidase-2 |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
| 242 |
thrombin |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
| 251 |
glutamyl endopeptidase I |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
| 273 |
matrix metallopeptidase-2 |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
| 274 |
HIV-1 retropepsin |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
| 286 |
trypsin 1 |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
| 330 |
cathepsin K |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
| 341 |
trypsin 1 |
25-609 |
N |
|
MS |
Schilling & Overall, 2008 |
