Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P22894

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-467	P	release of a signal peptide	NT	Blaeser et al., 1991
90	PCSK4 peptidase	85-94	N		CS	Remacle et al., 2008
90	PCSK6 peptidase	85-94	N		CS	Remacle et al., 2008
90	PCSK5 peptidase	85-94	N		CS	Remacle et al., 2008
90	PCSK7 peptidase	85-94	N		CS	Remacle et al., 2008
98	matrix metallopeptidase-3	21-467	P	normal turnover		Knauper et al., 1993
98	matrix metallopeptidase-10 (Homo sapiens-type)	21-467	P		NT	Knäuper et al., 1996
99	chymotrypsin A (cattle-type)	21-467	N			Knauper et al., 1990
99	cathepsin G	21-467	P		NT	Knauper et al., 1990
100	unknown peptidase	1-467	P		NT	<%Agarwal et al., 2012[]%>
262	matrix metallopeptidase-8	101-467	P			<%Knauper et al., 1993[]%>
267	matrix metallopeptidase-8	101-467	P	normal turnover		Fosang et al., 1996
338	trypsin 1	101-467	N		MS	Schilling & Overall, 2008
345	trypsin 1	101-467	N		MS	Schilling & Overall, 2008