Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P05305

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
17	unknown peptidase	1-212	P		NT	<%Agarwal et al., 2012[]%>
50	unknown peptidase	1-212	P		NT	<%Agarwal et al., 2012[]%>
52	furin	17-212	P			Blais et al., 2002
52	PCSK7 peptidase	17-212	P			Blais et al., 2002
56	thermolysin	53-68	N		NT	Vijayaraghavan et al., 1990
57	neprilysin	53-73	P		NT	Vijayaraghavan et al., 1990
57	endothelin-converting enzyme 1	53-73	P			Fahnoe et al., 2000
63	thermolysin	53-68	N		NT	Vijayaraghavan et al., 1990
65	endothelin-converting enzyme 1	53-73	P			Fahnoe et al., 2000
66	endothelin-converting enzyme 1	53-73	P			Fahnoe et al., 2000
68	thermolysin	53-73	N		NT	Vijayaraghavan et al., 1990
68	neprilysin	53-70	P		NT	Vijayaraghavan et al., 1990
70	thermolysin	53-73	N		NT	Vijayaraghavan et al., 1990
70	neprilysin	53-73	P		NT	Vijayaraghavan et al., 1990
70	endothelin-converting enzyme 1	53-73	P			Fahnoe et al., 2000
71	endothelin-converting enzyme 1	53-73	P			Fahnoe et al., 2000
71	carboxypeptidase A3	53-72	P			Schneider et al., 2007
72	carboxypeptidase A3	53-73	P			Schneider et al., 2007
73	cathepsin E	53-90	P	release of an activation peptide	AB	Robinson et al., 1992
73	endothelin-converting enzyme 1	53-90	P			Ahn & Johnson, 2004
73	endothelin-converting enzyme 2	53-90	P			Mzhavia et al., 2003
73	neprilysin-2	53-90	P			Carpentier et al., 2003
73	Kell blood-group peptidase	53-90	P			Lee et al., 1999
79	endothelin-converting enzyme 1	53-90	P			Fahnoe et al., 2000
83	chymase (Homo sapiens-type)	53-90	P			Raymond et al., 2003
83	kallikrein 1-related peptidase c2 (Rattus norvegicus)	53-90	P			Moreau et al., 1992
83	kallikrein 1-related peptidase c9 (Rattus sp.)	53-90	P			Moreau et al., 1992
84	matrix metallopeptidase-2	53-90	P			Fernandez-Patron et al., 1999
84	matrix metallopeptidase-9	53-90	P			Fernandez-Patron et al., 1999
86	endothelin-converting enzyme 1	53-90	P			Fahnoe et al., 2000
92	furin	17-212	P			Blais et al., 2002
92	PCSK7 peptidase	17-212	P			Blais et al., 2002
108	furin	17-212	P			Blais et al., 2002
168	furin	17-212	P			Blais et al., 2002
168	PCSK7 peptidase	17-212	P			Blais et al., 2002