Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01042

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-644	P		NT	<%Agarwal et al., 2012[]%>
100	peptidyl-Lys metallopeptidase	2-644	N		MS
112	peptidyl-Lys metallopeptidase	2-644	N		MS
114	kallikrein-related peptidase 14	19-644	P			Borgoņo et al., 2007
240	kallikrein-related peptidase 5	19-644	P		NT	Michael et al., 2005
269	kallikrein-related peptidase 5	19-644	P		NT	Michael et al., 2005
289	cathepsin D	19-644	P	normal turnover		Lenarcic et al., 1991
316	cathepsin D	19-644	P	normal turnover		Lenarcic et al., 1991
321	cathepsin D	19-644	P	normal turnover		Lenarcic et al., 1991
376	elastase-2	19-644	P			Imamura et al., 2004
379	cruzipain	19-644	P			Del Nery et al., 1997
379	cruzipain 2	19-644	P		NT	Del Nery et al., 1997
379	calpain-1	19-644	P			Imamura et al., 2004
379	calpain-2	19-644	P			Imamura et al., 2004
379	aminopeptidase Ap1	379-389	N			Wilkes et al., 1973
379	kallikrein 1	19-644	P			Del Nery et al., 1996
380	gingipain RgpA	19-644	N			Imamura et al., 2004
380	gingipain K	379-389	N			Pike et al., 1994
380	staphopain B	19-644	N			Massimi et al., 2002
380	lysyl aminopeptidase (bacteria)	380-389	N		MS	Richards & Nuņez, 2006
380	aminopeptidase A	380-389	N			Goto et al., 2007
380	cystinyl aminopeptidase	380-389	N			Keller, 1998
380	ERAP2 aminopeptidase	380-389	N		MS	Tanioka et al., 2003
380	aminopeptidase Q	380-389	N			Maruyama et al., 2007
380	aminopeptidase Ap1	380-389	N			Wilkes et al., 1973
380	kallikrein-related peptidase 2	19-644	P
380	plasma kallikrein	19-644	P
381	arginine aminopeptidase (Streptococcus-type)	381-389	N			Goldstein et al., 2002
381	lysyl aminopeptidase (bacteria)	381-389	N		MS	Richards & Nuņez, 2006
381	aminopeptidase Ey	381-385	N			Ichishima, 2004
381	aminopeptidase P2	381-389	N			Molinaro et al., 2005
381	bacillus Xaa-Pro aminopeptidase	381-383	N			Monnet, 2004
381	aminopeptidase P1	381-385	N			Harbeck & Mentlein, 1991
381	Mername-AA273 peptidase	381-389	N			Laurent et al., 2001
381	factor VII-activating peptidase	19-644	P		MS	Etscheid et al., 2002
382	nephrosin	381-387	N			Hung et al., 1997
382	prolyl oligopeptidase	381-389	N			Ito et al., 2004
382	dipeptidyl-peptidase II	381-385	N			McDonald & Ohkubo, 2004
383	nephrosin	382-389	N			Hung et al., 1997
383	prolyl oligopeptidase	381-389	N			Koida & Walter, 1976
383	dipeptidyl peptidase 4 (Aspergillus-type)	382-389	N			Monod & Beauvais, 2004
383	tripeptidyl-peptidase I	381-389	N			Oyama et al., 2005
384	cathepsin K	380-389	N		NT	Godat et al., 2004
384	oligopeptidase E	381-389	N			Fenster et al., 2004
384	coccolysin	381-389	N			Makinen & Makinen, 2004
384	nephrosin	381-389	N			Hung et al., 1997
384	halylysin b	381-389	N			Komori & Nikai, 2004
384	neprilysin	381-389	N			Matsas et al., 1984
384	eupitrilysin	381-389	N			Chow et al., 2009
384	plinsulysin	381-389	N			Huet et al., 2008
384	dactylysin	381-389	N			Clamagirand et al., 2004
385	cathepsin H	380-389	N		-	Brguljan et al., 2003
385	thimet oligopeptidase	381-389	N			Barrett & Chen, 2004
385	saccharolysin	381-389	N			D'Enfert et al., 2004
385	peptidyl-dipeptidase Dcp	381-387	N			Cunha et al., 2009
385	mitochondrial intermediate peptidase	381-389	N	release of a transit peptide		Isaya, 2004
385	oligopeptidase F	381-389	N			Pritchard, 2004
385	Pz-peptidase A	381-389	N			Pritchard, 2004
385	tropolysin	380-389	N			Morty et al., 2005
385	meprin alpha subunit	381-389	N		NT	Bertenshaw et al., 2001
385	nephrosin	381-389	N			Hung et al., 1997
385	penicillolysin	381-389	N			Ichishima, 2004
385	FALGPA-peptidase (Treponema denticola)	381-389	N			Mäkinen et al., 1995
385	oligopeptidase B	381-389	P			Morty et al., 2005
385	family S10 unassigned peptidases	381-386	N		NT	Umetsu et al., 1998
385	unknown peptidase	381-389	N			Bertenshaw et al., 2001
386	family S10 unassigned peptidases	381-387	N		NT	Umetsu et al., 1998
386	unknown peptidase	381-388	N			Corvol et al., 2004
387	peptidyl-dipeptidase Acer	381-389	N			Isaac, 2004
387	peptidyl-dipeptidase Ance	381-389	N			Wijffels et al., 1996
387	angiotensin-converting enzyme peptidase unit 2	381-389	N			Corvol et al., 2004
387	angiotensin-converting enzyme-2	380-388	P		MS	Vickers et al., 2002
387	peptidyl-dipeptidase Dcp	381-389	N			Cunha et al., 2009
387	coccolysin	381-389	N			Makinen & Makinen, 2004
387	matrix metallopeptidase-8	379-389	P		NT	Diekmann & Tschesche, 1994
387	lebetase	380-389	N		MS	Trummal et al., 2000
387	neprilysin	381-389	P			Matsas et al., 1984
387	endothelin-converting enzyme 1	381-389	N			Ahn & Johnson, 2004
387	endothelin-converting enzyme 2	381-389	P		MS	Mzhavia et al., 2003
387	neprilysin-2	381-389	N		NT	Rose et al., 2002
387	Zmp1 peptidase (Mycobacterium-type)	381-389	N			Carson et al., 2002
387	insulysin	380-389	N		MS	Malito et al., 2008
387	plinsulysin	381-389	N			Huet et al., 2008
387	dactylysin	381-389	N		NT	Carvalho et al., 1992
387	prolyl oligopeptidase	381-389	N			Mäkinen et al., 1995
387	family S10 unassigned peptidases	381-388	N		NT	Umetsu et al., 1998
387	lysosomal Pro-Xaa carboxypeptidase	381-388	N			Tan & Erdos, 2004
387	unknown peptidase	381-389	N			Corvol et al., 2004
388	matrix metallopeptidase-8	379-389	P		NT	Diekmann & Tschesche, 1994
388	carboxypeptidase N	381-389	P
388	carboxypeptidase M	381-389	N			Skidgel, 2004
388	carboxypeptidase B2	381-389	N		NT	Myles et al., 2003
388	chymase (Homo sapiens-type)	381-389	P			Raymond et al., 2003
388	duodenase	381-389	N		NT	Pemberton et al., 1997
388	family S10 unassigned peptidases	381-389	N		NT	Umetsu et al., 1998
389	cruzipain	19-644	P			Del Nery et al., 1997
389	cruzipain 2	19-644	P		NT	Del Nery et al., 1997
389	calpain-1	19-644	P			Imamura et al., 2004
389	calpain-2	19-644	P			Imamura et al., 2004
389	gingipain RgpA	19-644	N			Imamura et al., 2004
389	staphopain B	19-644	N			Massimi et al., 2002
389	factor VII-activating peptidase	19-644	P		NT	Etscheid et al., 2002
389	kallikrein 1	19-644	P			Gomes et al., 1997
389	kallikrein-related peptidase 2	19-644	P
389	plasma kallikrein	19-644	P
392	kallikrein-related peptidase 5	19-644	P		NT	Michael et al., 2005
393	elastase-2	19-644	P	normal turnover		Imamura et al., 2004
427	kallikrein-related peptidase 2	19-644	P			Charlesworth et al., 1999
427	plasma kallikrein	19-644	P			Charlesworth et al., 1999
437	factor VII-activating peptidase	19-644	P		NT	Etscheid et al., 2002
437	kallikrein-related peptidase 2	19-644	P			Charlesworth et al., 1999
449	tryptase alpha	19-644	P
457	kallikrein-related peptidase 2	19-644	P			Charlesworth et al., 1999