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Substrates for peptidase S53.003: tripeptidyl-peptidase I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Ala-Ala-NHPhNO2 Ala-Ala-Ala+NHPhNO2 S - Ala Ala Ala NAN - - - Vines & Warburton, 1998
Ala-Ala-Phe-NHMec Ala-Ala-Phe+NHMec S - Ala Ala Phe AMC - - - McDonald, 1998
Ala-Ala-Phe-NHPhNO2 Ala-Ala-Phe+NHPhNO2 S - Ala Ala Phe NAN - - - Vines & Warburton, 1998
Ala-Arg-Phe-Nph-Arg-Leu Ala-Arg-Phe+Nph-Arg-Leu S - Ala Arg Phe Nph Arg Leu - Oyama et al., 2005
Ala-Arg-Phe-Nph-Arg-Leu Ala-Arg-Phe+Nph-Arg-Leu S - Ala Arg Phe Nph Arg Leu - Oyama et al., 2005
angiotensin-1 P01019 34-43 Asp-Arg-Val+Tyr-Ile-His-Pro-Phe-His-Leu P MS - Asp Arg Val Tyr Ile His Pro Du et al., 2001
angiotensin-2 P01019 34-41 Asp-Arg-Val+Tyr-Ile-His-Pro-Phe N - Asp Arg Val Tyr Ile His Pro Oyama et al., 2005
angiotensin-3 P01019 35-41 Arg-Val-Tyr+Ile-His-Pro-Phe N - Arg Val Tyr Ile His Pro Phe McDonald, 1998 17773
angiotensin-3 P01019 37-41 Ile-His-Pro+Phe N - Ile His Pro Phe - - - Vines & Warburton, 1998
ATP synthase subunit C fragment Asp-Ile-Asp+Thr-peptide N - Asp Ile Asp Thr Ala Ala Lys Oyama et al., 2005
beta-neoendorphin P01213 175-183 Tyr-Gly-Gly+Phe-Leu-Arg-Lys-Tyr-Pro N - Tyr Gly Gly Phe Leu Arg Lys Du et al., 2001
bradykinin P01042 381-389 Arg-Pro-Pro+Gly-Phe-Ser-Pro-Phe-Arg N - Arg Pro Pro Gly Phe Ser Pro Oyama et al., 2005
Cholecystokinin-5 P06307 99-103 Gly-Trp-Met101+Asp-Phe-NH2 P MS - Gly Trp Met Asp Phe - - Bernardini & Warburton, 2002
cholecystokinin-8 P09240 96-103 Asp-Tyr-Met+Gly-Trp-Met-Asp-Phe P MS - Asp Tyr Met Gly Trp Met Asp Warburton & Bernardini, 2002
dynorphin A(1-8) P01213 207-214 Tyr-Gly-Gly+Phe-Leu-Arg-Arg-Ile N - Tyr Gly Gly Phe Leu Arg Arg Oyama et al., 2005
gamma-endorphin P01189 237-253 Tyr-Gly-Gly+Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu N - Tyr Gly Gly Phe Met Thr Ser Oyama et al., 2005
glucagon P01275 53-81 His-Ser+Gly-peptide P MS - His Ser Gln Gly Thr Phe Thr Vines & Warburton, 1998
glucagon P01275 56-81 Gly-Thr+Thr-peptide P MS - Gly Thr Phe Thr Ser Asp Tyr Vines & Warburton, 1998
glucagon P01275 59-81 Thr-Ser+Tyr-peptide P MS - Thr Ser Asp Tyr Ser Lys Tyr Vines & Warburton, 1998
glucagon P01275 62-81 Tyr-Ser-Lys+Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr P MS - Tyr Ser Lys Tyr Leu Asp Ser Vines & Warburton, 1998
glucagon P01275 65-81 Tyr-Leu-Asp+Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr P MS - Tyr Leu Asp Ser Arg Arg Ala Vines & Warburton, 1998
glucagon P01275 68-81 Ser-Arg-Arg+Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr P MS - Ser Arg Arg Ala Gln Asp Phe Vines & Warburton, 1998
glucagon P01275 71-81 Ala-Gln-Asp+Phe-Val-Gln-Trp-Leu-Met-Asn-Thr P MS - Ala Gln Asp Phe Val Gln Trp Vines & Warburton, 1998
glucagon P01275 74-81 Phe-Val-Gln+Trp-Leu-Met-Asn-Thr P MS - Phe Val Gln Trp Leu Met Asn Vines & Warburton, 1998
glucagon P01275 77-81 Trp-Leu-Met+Asn-Thr P MS - Trp Leu Met Asn Thr - - Vines & Warburton, 1998
Gly-Pro-Leu-NHNap Gly-Pro-Leu+NHNap S - Gly Pro Leu NAP - - - Vines & Warburton, 1998
Gly-Pro-Met-NHMec Gly-Pro-Met+NHMec S - Gly Pro Met AMC - - - McDonald, 1998
Gly-Pro-Met-NHNap Gly-Pro-Met+NHNap S - Gly Pro Met NAP - - - Vines & Warburton, 1998
Mca-Gly-Lys-Pro-Ile-Pro-Phe-Phe-Arg-Leu-Lys(DNP)-NH2 MOCAc-Gly-Lys-Pro-Ile-Pro-Phe+Phe-Arg-Leu-Lys(DNP)-NH2 S Pro Ile Pro Phe Phe Arg Leu Lyd Ezaki et al., 2000
neuromedin-B P08949 47-56 Gly-Asn-Leu+Trp-Ala-Thr-Gly-His-Phe-Met-NH2 N - Gly Asn Leu Trp Ala Thr Gly Du et al., 2001
neurotensin P30990 151-163 Gln-Leu-Tyr+Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu N - Gln Leu Tyr Glu Asn Lys Pro Du et al., 2001
Phe-Pro-Ala-NHNap Phe-Pro-Ala+NHNap S - Phe Pro Ala NAP - - - McDonald, 1998
poly(Gly-Pro-Ala) peptide-Gly-Pro-Ala+Gly-Pro-Ala-peptide N NPe Gly Pro Ala Gly Pro Ala CPe McDonald, 1998
somatotropin Ala-Phe-Pro+Ala-peptide N - Ala Phe Pro Ala Met Ser Leu McDonald, 1998
substance P Arg-Pro-Lys+Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 N - Arg Pro Lys Pro Gln Gln Phe Oyama et al., 2005
tripeptidyl-peptidase I O14773 20-563 His-Val-Asp168+Phe-peptide P - His Val Asp Phe Val Gly Gly Guhaniyogi et al., 2008 24172
tripeptidyl-peptidase I O14773 169-563 Phe-Val-Gly171+Gly-peptide P - Phe Val Gly Gly Leu His Arg Guhaniyogi et al., 2008
tripeptidyl-peptidase I O14773 172-563 Gly-Leu-His174+Arg-peptide P - Gly Leu His Arg Phe Pro Pro Guhaniyogi et al., 2008
tripeptidyl-peptidase I O14773 175-563 Thr-Ser-Ser181+Leu-peptide P - Thr Ser Ser Leu Arg Gln Arg Guhaniyogi et al., 2008 22590
tripeptidyl-peptidase I O14773 182-563 Glu-Pro-Gln189+Val-peptide P - Glu Pro Gln Val Thr Gly Thr Guhaniyogi et al., 2008 22589
tripeptidyl-peptidase I O14773 190-563 Val-Thr-Gly192+Thr-peptide P - Val Thr Gly Thr Val Gly Leu Guhaniyogi et al., 2008
tripeptidyl-peptidase I O14773 193-563 Thr-Val-Gly195+Leu-peptide P - Thr Val Gly Leu His Leu Gly Guhaniyogi et al., 2008 22588
tripeptidyl-peptidase I O14773 20-563 Thr-Leu-His97+Thr-peptide P - Thr Leu His Thr Val Gln Lys Golabek et al., 2004 22591
[des-Asp-Tyr-Met]Cholecystokinin-8 P09240 99-103 Gly-Trp-Met+Asp-Phe P MS - Gly Trp Met Asp Phe - - Warburton & Bernardini, 2002
[des-Tyr1]-dynorphin P01214 210-225 Gly-Gly-Phe+Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln N - Gly Gly Phe Leu Arg Arg Ile McDonald, 1998

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