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Substrates for peptidase S01.017: kallikrein-related peptidase 5

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Antileukoproteinase P03973 26-132 peptide-Arg45+Tyr-peptide P NT Gln Cys Leu Arg Tyr Lys Lys Pro Borgoņo et al., 2007
cathelicidin antimicrobial peptide P49913 134-170 peptide-Arg140+Lys-peptide P Asp Phe Phe Arg Lys Ser Lys Glu Yamasaki et al., 2006 22745
cathelicidin antimicrobial peptide P49913 134-170 peptide-Arg152+Ile-peptide P Glu Phe Lys Arg Ile Val Gln Arg Yamasaki et al., 2006 22746
cathelicidin antimicrobial peptide P49913 134-170 peptide-Arg156+Ile-peptide P Ile Val Gln Arg Ile Lys Asp Phe Yamasaki et al., 2006 22747
cathelicidin antimicrobial peptide P49913 134-170 peptide-Arg162+Asn-peptide P Asp Phe Leu Arg Asn Leu Val Pro Yamasaki et al., 2006 22748
cathelicidin antimicrobial peptide P49913 134-170 peptide-Arg167+Thr-peptide P Leu Val Pro Arg Thr Glu Ser Gly Yamasaki et al., 2006 22749
Cathelicidin antimicrobial peptide P49913 1-170 peptide-Ala133+Leu-peptide P Lys Arg Phe Ala Leu Leu Gly Asp Yamasaki et al., 2006
Desmoglein-1 Q02413 50-1049 peptide-Arg242+Asp-peptide P NT Gly Ser Asp Arg Asp Gly Gly Ala Borgoņo et al., 2007
Desmoglein-1 Q02413 50-1049 peptide-Arg422+Tyr-peptide P NT Thr Thr Val Arg Tyr Val Met Gly Borgoņo et al., 2007
Desmoglein-1 Q02413 50-1049 peptide-Arg146+Val-peptide P NT Leu Arg Val Arg Val Leu Asp Ile Borgoņo et al., 2007
Fibrinogen alpha chain P02671 20-866 peptide-Arg367+Gly-peptide P NT Ser Ser Glu Arg Gly Ser Ala Gly Michael et al., 2005
Fibrinogen alpha chain P02671 20-866 peptide-Arg426+Glu-peptide P NT Gly Thr Arg Arg Glu Tyr His Thr Michael et al., 2005
fibrinogen beta chain P02675 31-491 peptide-Arg44+Gly-peptide P Phe Ser Ala Arg Gly His Arg Pro Michael et al., 2005
Fibrinogen beta chain P02675 31-491 peptide-Lys83+Lys-peptide P NT Ala Thr Gln Lys Lys Val Glu Arg Michael et al., 2005
hepatocyte growth factor activator Q04756 373-655 peptide-Arg407+Ile-peptide P Leu Arg Pro Arg Ile Ile Gly Gly Mukai et al., 2008 20893
Insulin-like growth factor-binding protein 1 P08833 26-259 peptide-Lys162+Ala-peptide P NT Asp Gly Ser Lys Ala Leu His Val Michael et al., 2006
Insulin-like growth factor-binding protein 1 P08833 1-259 peptide-Gly25+Ala-peptide P NT Val Thr Ala Gly Ala Pro Trp Gln Michael et al., 2006
Insulin-like growth factor-binding protein 2 P18065 1-325 peptide-Arg35+Gln-peptide P NT Gly Gly Ala Arg Ala Glu Val Leu Michael et al., 2006
Insulin-like growth factor-binding protein 2 P18065 36-325 peptide-Arg200+Gln-peptide P NT Glu Gln His Arg Gln Met Gly Lys Michael et al., 2006
Insulin-like growth factor-binding protein 3 P17936 28-291 peptide-Arg185+Tyr-peptide P NT Asp Ser Gln Arg Tyr Lys Val Asp Michael et al., 2006
Insulin-like growth factor-binding protein 3 P17936 28-291 peptide-Arg233+Gly-peptide P NT Leu Ser Pro Arg Gly Val His Ile Michael et al., 2006
Insulin-like growth factor-binding protein 3 precursor P17936 1-291 peptide-Ala27+Gly-peptide P NT Val Ala Arg Ala Gly Ala Ser Ser Michael et al., 2006
Insulin-like growth factor-binding protein 4 P22692 22-258 peptide-Arg191+Thr-peptide P NT Ser Gln Ser Arg Thr His Glu Asp Michael et al., 2006
Insulin-like growth factor-binding protein 4 precursor P22692 1-258 peptide-Gly21+Asp-peptide P NT Pro Ser Leu Gly Asp Glu Ala Ile Michael et al., 2006
Insulin-like growth factor-binding protein 5 P24593 21-272 peptide-Cys27+Glu-peptide P NT Phe Val His Cys Glu Pro Cys Asp Michael et al., 2006
Insulin-like growth factor-binding protein 5 P24593 21-272 peptide-Arg143+Ile-peptide P NT Lys His Thr Arg Ile Ser Glu Leu Michael et al., 2006
Insulin-like growth factor-binding protein 5 P24593 21-272 peptide-Arg212+Ala-peptide P NT Met Val Pro Arg Ala Val Tyr Leu Michael et al., 2006
Kallikrein-1 P06870 21-27 peptide-Arg24+Ile-Val-Gly N Ile Gln Ser Arg Ile Val Gly - Michael et al., 2006
Kallikrein-1 precursor P06870 19-262 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Yoon et al., 2007
Kallikrein-10 precursor O43240 31-276 peptide-Arg42+Leu-peptide P NT Asn Asp Thr Arg Leu Asp Pro Glu Yoon et al., 2007
Kallikrein-11 Q9UBX7 31-36 Glu-Thr-Arg+Ile-Ile-Lys N - Glu Thr Arg Ile Ile Lys - Michael et al., 2006
Kallikrein-12 Q9UKR0-1 15-21 peptide-Lys21+Ile-peptide N Ala Thr Pro Lys Ile Phe Asn - Michael et al., 2006
Kallikrein-13 precursor Q9UKR3 17-277 peptide-Lys25+Val-peptide P NT Glu Ser Ser Lys Val Leu Asn Thr Yoon et al., 2007
Kallikrein-15 Q9H2R5-2 18-24 peptide-Lys21+Leu-peptide N Asp Gly Asp Lys Leu Leu Glu - Michael et al., 2006
Kallikrein-15 precursor Q9H2R5 17-256 peptide-Lys21+Leu-peptide P NT Asp Gly Asp Lys Leu Leu Glu Gly Yoon et al., 2007
Kallikrein-2 precursor P20151 19-261 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Michael et al., 2006
Kallikrein-8 O60259 29-35 peptide-Lys32+Val-peptide N Gln Glu Asp Lys Val Leu Gly - Michael et al., 2006
Kallikrein-8 precursor O60259 29-260 Gln-Glu-Asp-Lys32+Val-peptide P NT Gln Glu Asp Lys Val Leu Gly Gly Yoon et al., 2007
Kallikrein-9 Q9UKQ9 19-25 peptide-Arg22+Ala-peptide N Ala Asp Thr Arg Ala Ile Gly - Michael et al., 2006
Kallikrein-9 precursor Q9UKQ9 16-250 peptide-Arg22+Ala-peptide P NT Ala Asp Thr Arg Ala Ile Gly Ala Yoon et al., 2007
kallikrein-related peptidase 14 Q9P0G3 19-251 peptide-Lys40+Ile-peptide P Asp Glu Asn Lys Ile Ile Gly Gly Brattsand et al., 2005 21058
kallikrein-related peptidase 5 Q9Y337 23-293 peptide-Arg66+Ile-peptide P Ser Ser Ser Arg Ile Ile Asn Gly Brattsand et al., 2005 21055
kallikrein-related peptidase 7 P49862 23-253 peptide-Lys29+Ile-peptide P Gln Gly Asp Lys Ile Ile Asp Gly Brattsand et al., 2005 21056
Kininogen-1 P01042 19-644 peptide-Arg240+Ile-peptide P NT Ile Gln Leu Arg Ile Ala Ser Phe Michael et al., 2005
Kininogen-1 P01042 19-644 peptide-Arg269+Asp-peptide P NT Gly Cys Pro Arg Asp Ile Pro Thr Michael et al., 2005
Kininogen-1 P01042 19-644 peptide-Arg392+Ile-peptide P NT Arg Ser Ser Arg Ile Gly Glu Ile Michael et al., 2005
Meprin A subunit alpha precursor Q16819 1-746 Peptide-Arg65+Asn-Peptide P - Gln Lys Ser Arg Asn Gly Leu Arg Debela et al., 2008
Meprin A subunit beta Q16820 1-701 Peptide-Arg61+Asn-Peptide P - Ala Gln Ile Arg Asn Ser Ile Ile Debela et al., 2008
Plasminogen P00747 20-810 peptide-Lys96+Lys-peptide P NT Leu Phe Glu Lys Lys Val Tyr Leu Michael et al., 2005
Plasminogen P00747 20-810 peptide-Arg549+Lys-peptide P NT Thr Asn Pro Arg Lys Leu Tyr Asp Michael et al., 2005
Prostate-specific antigen P07288 25-261 peptide-Arg109+Phe-peptide P NT Leu Lys Asn Arg Phe Leu Arg Pro Michael et al., 2006
Prostate-specific antigen P07288 25-261 peptide-Lys206+Ser-peptide P NT Thr Gly Gly Lys Ser Thr Cys Ser Michael et al., 2006
Prostate-specific antigen precursor P07288 18-261 peptide-Lys169+Lys-peptide P NT Leu Thr Pro Lys Lys Leu Gln Cys Debela et al., 2008
Prostate-specific antigen precursor P07288 18-261 peptide-Arg24+Ile-peptide P NT Ile Leu Ser Arg Ile Val Gly Gly Michael et al., 2006
proteinase-activated receptor 1 P25116 27-425 peptide-Arg41+Ser-peptide P MS Leu Asp Pro Arg Ser Phe Leu Leu Oikonomopoulou et al., 2006 20607
proteinase-activated receptor 1 P25116 27-425 peptide-Phe43+Leu-peptide P MS Pro Arg Ser Phe Leu Leu Arg Asn Oikonomopoulou et al., 2006 20608
proteinase-activated receptor 2 P55085 26-397 peptide-Arg29+Ser-peptide P MS Gly Thr Asn Arg Ser Ser Lys Gly Oikonomopoulou et al., 2006 20616
proteinase-activated receptor 2 Q63645 26-397 peptide-Lys34+Gly-peptide P MS Pro Asn Ser Lys Gly Arg Ser Leu Oikonomopoulou et al., 2006 20643
proteinase-activated receptor 2 Q63645 26-397 peptide-Arg36+Ser-peptide P MS Ser Lys Gly Arg Ser Leu Ile Gly Oikonomopoulou et al., 2006
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Arg47+Gly-peptide P MS Pro Ala Pro Arg Gly Tyr Pro Gly Oikonomopoulou et al., 2006 20621
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Gly51+Gln-peptide P MS Gly Tyr Pro Gly Gln Val Cys Ala Oikonomopoulou et al., 2006 20622
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Gly35+Asp-peptide P MS Thr Gly Gly Gly Asp Asp Ser Thr Oikonomopoulou et al., 2006 20623
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Asp36+Asp-peptide P MS Gly Gly Gly Asp Asp Ser Thr Pro Oikonomopoulou et al., 2006 20624
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Asp37+Ser-peptide P MS Gly Gly Asp Asp Ser Thr Pro Ser Oikonomopoulou et al., 2006 20625
proteinase-activated receptor 4 precursor Q920E0 17-395 peptide-Arg49+Gly-peptide P MS Pro Asn Pro Arg Gly Phe Pro Gly Oikonomopoulou et al., 2006 20641
proteinase-activated receptor 4 precursor Q920E0 17-395 peptide-Gly50+Phe-peptide P MS Asn Pro Arg Gly Phe Pro Gly Lys Oikonomopoulou et al., 2006 20642
S-2222 Bz-Ile-Glu-Gly-Arg+NHPhNO2 S Ile Glu Gly Arg NAN - - - Brattsand et al., 2005
S-2288 D-Ile-Pro-Arg+NHPhNO2 S - DIl Pro Arg NAN - - - Brattsand et al., 2005
S-2302 D-Pro-Phe-Arg+NHPhNO2 S - DPr Phe Arg NAN - - - Brattsand et al., 2005
Somatotropin P01241 27-217 Peptide-Arg34+Leu-Peptide P NT Pro Leu Ser Arg Leu Phe Asp Asn Komatsu et al., 2007
Somatotropin P01241 27-217 Peptide-Arg120+Ser-Peptide P NT Gln Phe Leu Arg Ser Val Phe Ala Komatsu et al., 2007
Urokinase-type plasminogen activator P00749 21-431 Peptide-Lys178+Ile-Peptide P - Pro Arg Phe Lys Ile Ile Gly Gly Debela et al., 2008
Vitronectin P04004 20-478 peptide-Arg27+Cys-peptide P NT Cys Lys Gly Arg Cys Thr Glu Gly Michael et al., 2005
Z-Leu-Arg-NHMec Z-Leu-Arg+NHMec S - Z Leu Arg AMC - - - Debela et al., 2006
Z-Phe-Arg-NHMec Z-Phe-Arg-NHMec S - Z Phe Arg AMC - - - Debela et al., 2006

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