Substrates for peptidase S01.143: tryptase alpha

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Abz-Arg-Gln-Asp-Arg-ANB-NH2			Abz-Arg-Gln-Asp-Arg+ANB-NH2	S		Arg	Gln	Asp	Arg	ANB	NH2	-	-	Wysocka %eta, 2010
Abz-Arg-Gln-Asp-Lys-ANB-NH2			Abz-Arg-Gln-Asp-Lys+ANB-NH2	S		Arg	Gln	Asp	Lys	ANB	NH2	-	-	Wysocka %eta, 2010
arginyl bond			peptide-Arg+peptide	N		-	-	NPe	Arg	CPe	-	-	-
Boc-Phe-Ser-Arg-NHMec			Boc-Phe-Ser-Arg+NHMec	S		Boc	Phe	Ser	Arg	AMC	-	-	-	Wysocka %eta, 2010
Elafin precursor	P19957	23-117	peptide-Lys60+Ala-peptide	P		Asp	Lys	Val	Lys	Ala	Gln	Glu	Pro	Guyot et al., 2005	22164
fibrinogen alpha chain	P02671	36-866	peptide-Arg591+Gly-peptide	P	NT	Ser	Tyr	Asn	Arg	Gly	Asp	Ser	Thr	Thomas et al., 1998
fibrinogen beta chain	P02675	45-491	peptide-Lys51+Lys-peptide	P		Pro	Leu	Asp	Lys	Lys	Arg	Glu	Glu	Thomas et al., 1998	20370
kininogen-1	P01042	19-644	peptide-Arg+Asp-peptide	P		Lys	His	Glu	Arg	Asp	Gln	Gly	His		17249
lysyl bond			peptide-Lys+peptide	N		-	-	NPe	Lys	CPe	-	-	-
proteinase-activated receptor 1	P25116	35-46	peptide-Arg41+Ser-peptide	P		Leu	Asp	Pro	Arg	Ser	Phe	Leu	Leu	Molino et al., 1997	20550
proteinase-activated receptor 1	P25116	41-55	peptide-Arg46+Asn-peptide	P		Phe	Leu	Leu	Arg	Asn	Pro	Asn	Asp	Molino et al., 1997	20551
proteinase-activated receptor 1	P25116	41-55	peptide-Lys51+Tyr-peptide	P		Pro	Asn	Asp	Lys	Tyr	Glu	Pro	Phe	Molino et al., 1997	20552
proteinase-activated receptor 2	P55085	31-45	peptide-Arg36+Ser-peptide	P		Ser	Lys	Gly	Arg	Ser	Leu	Ile	Gly	Molino et al., 1997	20548
proteinase-activated receptor 2	P55085	31-45	peptide-Lys41+Val-peptide	P		Leu	Ile	Gly	Lys	Val	Asp	Gly	Thr	Molino et al., 1997	20549
retinoic acid receptor responder protein 2 precursor	Q99969	17-163	peptide-Lys158+Ala-peptide	P		Ala	Phe	Ser	Lys	Ala	Leu	Pro	Arg	Zabel et al., 2005
Tos-Gly-Pro-Lys-NHPhNO2			Tos-Gly-Pro-Lys+NHPhNO2	S		Tos	Gly	Pro	Lys	NAN	-	-	-
urokinase-type plasminogen activator	P00749	21-431	peptide-Lys158+Ile-peptide	P		Pro	Arg	Phe	Lys	Ile	Ile	Gly	Gly		17250
vasoactive intestinal peptide			His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg+Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2	N		Thr	Arg	Leu	Arg	Lys	Gln	Met	Ala
vasoactive intestinal peptide	P48143	129-156	His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys+Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2	N		Met	Ala	Val	Lys	Lys	Tyr	Leu	Asn		17253
vasoactive intestinal peptide			His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys+Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2	N		Arg	Leu	Arg	Lys	Gln	Met	Ala	Val
vasoactive intestinal peptide	P48143	129-156	His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys+Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2	N		Ala	Val	Lys	Lys	Tyr	Leu	Asn	Ser		17254
Z-Gly-Pro-Arg-NHPhNO2			Z-Gly-Pro-Arg+NHPhNO2	S		Z	Gly	Pro	Arg	NAN	-	-	-
Z-Lys-SBzl			Z-Lys+SBzl	S		-	-	Z	Lys	SBz	-	-	-