Substrates for peptidase C01.075: cruzipain
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
| Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abz-Ala-Lys-Leu-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Ala-Lys-Leu-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Ala | Lys | Leu | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-EDDnp | Abz-Gly-Phe-Ser-Pro-Phe-Arg+Ser-Ser-Arg-Gln-EDDnp | S | Ser | Pro | Phe | Arg | Ser | Ser | Arg | Gln | Del Nery et al., 1997 | |||||
| Abz-Leu-Gly-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp | Abz-Leu-Gly+Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp | S | - | Abz | Leu | Gly | Met | Ile | Ser | Leu | Del Nery et al., 1997 | |||||
| Abz-Leu-Gly-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-NH2 | Abz-Leu-Gly+Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-NH2 | S | - | Abz | Leu | Gly | Met | Ile | Ser | Leu | Del Nery et al., 1997 | |||||
| Abz-Leu-Gly-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-NH2 | Abz-Leu-Gly-Met-Ile-Ser-Leu-Met+Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-NH2 | S | Ile | Ser | Leu | Met | Lys | Arg | Pro | Pro | Del Nery et al., 1997 | |||||
| Abz-Leu-Gly-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-NH2 | Abz-Leu-Gly-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg+Ser-Ser-Arg-Ile-NH2 | N | Ser | Pro | Phe | Arg | Ser | Ser | Arg | Ile | Del Nery et al., 1997 | |||||
| Abz-Lys-Ala-Leu-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Ala-Leu-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Ala | Leu | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Leu-Arg-Phe-Ser-Lys-Gln-EDDnp | Abz-Lys-Leu-Arg+Phe-Ser-Lys-Gln-EDDnp | S | Abz | Lys | Leu | Arg | Phe | Ser | Lys | Gln | Del Nery et al., 1997 | |||||
| Abz-Lys-Leu-Cys(Bzl)-Phe-Ser-Lys-Gln-EDDnp | Abz-Lys-Leu-Cys(Bzl)+Phe-Ser-Lys-Gln-EDDnp | S | Abz | Lys | Leu | CyB | Phe | Ser | Lys | Gln | Del Nery et al., 1997 | |||||
| Abz-Lys-Leu-Gly-Phe-Ser-Lys-Gln-EDDnp | Abz-Lys-Leu-Gly+Phe-Ser-Lys-Gln-EDDnp | S | Abz | Lys | Leu | Gly | Phe | Ser | Lys | Gln | Del Nery et al., 1997 | |||||
| Abz-Lys-Leu-Phe-Phe-Ser-Lys-Gln-EDDnp | Abz-Lys-Leu-Phe+Phe-Ser-Lys-Gln-EDDnp | S | Abz | Lys | Leu | Phe | Phe | Ser | Lys | Gln | Del Nery et al., 1997 | |||||
| Abz-Lys-Leu-Ser(Bzl)-Phe-Ser-Lys-Gln-EDDnp | Abz-Lys-Leu-Ser(Bzl)+Phe-Ser-Lys-Gln-EDDnp | S | Abz | Lys | Leu | SeB | Phe | Ser | Lys | Gln | Del Nery et al., 1997 | |||||
| Abz-Lys-Leu-Thr(Bzl)-Phe-Ser-Lys-Gln-EDDnp | Abz-Lys-Leu-Thr(Bzl)+Phe-Ser-Lys-Gln-EDDnp | S | Abz | Lys | Leu | ThB | Phe | Ser | Lys | Gln | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Ala-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Ala-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Ala | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Ala-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Ala+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Ala | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Arg-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Arg+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Arg | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Cys(tBu)-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Cys(tBu)+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Cyt | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-His-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-His+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | His | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Ile-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Ile+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Ile | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Leu-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Leu+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Leu | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Lys-Ala-Ala-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Lys+Ala-Ala-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Lys | Ala | Ala | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Lys-Ala-Lys-Ala-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Lys+Ala-Lys-Ala-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Lys | Ala | Lys | Ala | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Lys-Ala-Lys-Arg-Ala-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Lys+Ala-Lys-Arg-Ala-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Lys | Ala | Lys | Arg | Ala | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Lys-Ala-Lys-Pro-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Lys+Ala-Lys-Pro-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Lys | Ala | Lys | Pro | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Lys-Ala-Pro-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Lys+Ala-Pro-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Lys | Ala | Pro | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Lys-Pro-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys+Leu-Lys-Pro-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | - | Abz | Lys | Lys | Leu | Lys | Pro | Lys | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Met-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Met+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Met | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Phe-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Phe+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Phe | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Pro-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys+Leu-Pro-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | - | Abz | Lys | Lys | Leu | Pro | Ala | Lys | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Trp-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Trp+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Trp | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Tyr-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Tyr+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Tyr | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Leu-Val-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Leu-Val+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Leu | Val | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Phe-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Phe-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Phe | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Pro-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Pro-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Pro | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Trp-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Trp-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Trp | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Tyr-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Tyr-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Tyr | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Lys-Val-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Lys-Val-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Lys | Val | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Lys-Pro-Leu-Lys-Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | Abz-Lys-Pro-Leu-Lys+Ala-Lys-Lys-Arg-Tyr(NO2)-Asp-OH | S | Lys | Pro | Leu | Lys | Ala | Lys | Lys | Arg | Del Nery et al., 1997 | |||||
| Abz-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp | Abz-Met-Ile-Ser-Leu-Met+Lys-Arg-Pro-Gln-EDDnp | S | Ile | Ser | Leu | Met | Lys | Arg | Pro | Gln | Del Nery et al., 1997 | |||||
| Abz-Phe-Arg-Ala-Lys(Dnp)-NH2 | Abz-Phe-Arg+Ala-Lys(Dnp)-NH2 | S | - | Abz | Phe | Arg | Ala | Lyd | NH2 | - | Judice et al., 2004 | |||||
| Abz-Phe-Arg-Ala-Lys(Dnp)-OH | Abz-Phe-Arg+Ala-Lys(Dnp)-OH | S | - | Abz | Phe | Arg | Ala | Lyd | - | - | Judice et al., 2004 | |||||
| Abz-Phe-Arg-Lys(Dnp)-TrpOH | Abz-Phe-Arg+Lys(Dnp)-Trp-OH | S | - | Abz | Phe | Arg | Lyd | Trp | - | - | Judice et al., 2004 | |||||
| Ac-Leu-Thr-Phe-Lys-ACC | Ac-Leu-Thr+Phe-Lys-ACC | S | - | Ac | Leu | Thr | Phe | Lys | ACC | - | Harris et al., 2000 | |||||
| cruzipain precursor | P25779 | 19-467 | peptide-Gly122+Ala-peptide | P | Glu | Val | Val | Gly | Ala | Pro | Ala | Ala | Cazzulo, 2004 | 16098 | ||
| cruzipain precursor | P25779 | 19-467 | peptide-Gly337+Gly-peptide | P | Ala | Val | Val | Gly | Gly | Pro | Gly | Pro | Cazzulo, 2004 | 16097 | ||
| epsilon-NH2-Cap-Leu-Arg-NHMec | epsilon-NH2-Cap-Leu-Arg+NHMec | S | - | Cap | Leu | Arg | AMC | - | - | - | Del Nery et al., 1997 | |||||
| epsilon-NH2-Cap-Leu-Cys(Bzl)-NHMec | epsilon-NH2-Cap-Leu-Cys(Bzl)+NHMec | S | - | Cap | Leu | CyB | AMC | - | - | - | Lima et al., 2001 | |||||
| epsilon-NH2-Cap-Leu-Phe-NHMec | epsilon-NH2-Cap-Leu-Phe+NHMec | S | - | Cap | Leu | Phe | AMC | - | - | - | Del Nery et al., 1997 | |||||
| epsilon-NH2-Cap-Leu-Thr(Bzl)-NHMec | epsilon-NH2-Cap-Leu-Thr(Bzl)+NHMec | S | - | Cap | Leu | ThB | AMC | - | - | - | Del Nery et al., 1997 | |||||
| insulin A chain (oxidized) | P01317 | 85-105 | peptide-Ala92+Ser-peptide | N | NT | Gln | Cys | Cys | Ala | Ser | Val | Cys | Ser | Raimondi et al., 1991 | ||
| insulin A chain (oxidized) | P01317 | 85-105 | peptide-Ser96+Leu-peptide | N | NT | Ser | Val | Cys | Ser | Leu | Tyr | Gln | Leu | Raimondi et al., 1991 | ||
| insulin A chain (oxidized) | P01317 | 85-105 | peptide-Tyr98+Gln-peptide | N | NT | Cys | Ser | Leu | Tyr | Gln | Leu | Glu | Asn | Raimondi et al., 1991 | ||
| insulin A chain (oxidized) | P01317 | 85-105 | peptide-Gln99+Leu-peptide | N | NT | Ser | Leu | Tyr | Gln | Leu | Glu | Asn | Tyr | Raimondi et al., 1991 | ||
| insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn+Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | - | Phe | Val | Asn | Gln | His | Leu | Cya | Raimondi et al., 1991 | |||
| insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | Val | Glu | Ala | Leu | Tyr | Leu | Val | Cya | Raimondi et al., 1991 | |||
| insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | His | Leu | Val | Glu | Ala | Leu | Tyr | Leu | Raimondi et al., 1991 | |||
| insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | Glu | Ala | Leu | Tyr | Leu | Val | Cya | Gly | Raimondi et al., 1991 | ||
| insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu+Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | Ala | Leu | Tyr | Leu | Val | Cya | Gly | Glu | Raimondi et al., 1991 | ||
| insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala | N | NT | Arg | Gly | Phe | Phe | Tyr | Thr | Pro | Lys | Raimondi et al., 1991 | ||
| kininogen-1 | P01042 | 19-644 | peptide-Met361+Lys-peptide | P | Ile | Ser | Leu | Met | Lys | Arg | Pro | Pro | Del Nery et al., 1997 | 16100 | ||
| kininogen-1 | P01042 | 19-644 | peptide-Arg371+Ser-peptide | P | Ser | Pro | Phe | Arg | Ser | Ser | Arg | Ile | Del Nery et al., 1997 | 16099 | ||
| Z-Arg-Arg-NHMec | Z-Arg-Arg+NHMec | S | - | Z | Arg | Arg | AMC | - | - | - | Lima et al., 2001 | |||||
| Z-Leu-Arg-NHMec | Z-Leu-Arg+NHMec | S | - | Z | Leu | Arg | AMC | - | - | - | Lima et al., 2001 | |||||
| Z-Phe-Arg-NHMec | Z-Phe-Arg+NHMec | S | - | Z | Phe | Arg | AMC | - | - | - | Lima et al., 2001 |
