Substrates for peptidase S28.001: lysosomal Pro-Xaa carboxypeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
angiotensin-2 P01019 34-41 Asp-Arg-Val-Tyr-Ile-His-Pro+Phe N Tyr Ile His Pro Phe - - - Tan & Erdos, 2004 17732
angiotensin-3 P01019 35-41 Arg-Val-Tyr-Ile-His-Pro+Phe N Tyr Ile His Pro Phe - - - Tan & Erdos, 2004
consensus prolyl bond X-Pro+hydrophobic amino acid N - - NPe Pro HYD - - - Tan & Erdos, 2004
consensus prolyl bond X-Pro+hydrophobic amino acid N - - NBk Pro HYD - - - Tan & Erdos, 2004
endothelin B receptor-like protein 2 O60883 67-74 Tyr-Pro-Arg-Pro-Ile-His-Pro+Ala P MS Pro Ile His Pro Ala - - - Zhao et al., 2010
Z-Pro-Ala Z-Pro+Ala S - - Z Pro Ala - - - Tan & Erdos, 2004
Z-Pro-Gly Z-Pro+Gly S - - Z Pro Gly - - - Tan & Erdos, 2004
Z-Pro-Leu Z-Pro+Leu S - - Z Pro Leu - - - Tan & Erdos, 2004
Z-Pro-Phe Z-Pro+Phe S - - Z Pro Phe - - - Tan & Erdos, 2004
Z-Pro-Val Z-Pro+Val S - - Z Pro Val - - - Tan & Erdos, 2004
[desArg9]-bradykinin P01042 381-388 Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe N Gly Phe Ser Pro Phe - - - Tan & Erdos, 2004