Substrates for peptidase M14.006: carboxypeptidase M

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe+Arg	N		Phe	Ser	Pro	Phe	Arg	-	-	-	Skidgel, 2004	17035
Bz-Ala-Lys			Bz-Ala+Lys	S		-	-	Bz	Ala	Lys	-	-	-	Skidgel et al., 1989
Bz-Gly-Arg			Bz-Gly+Arg	S		-	-	Bz	Gly	Arg	-	-	-	Skidgel et al., 1989
Bz-Gly-Lys			Bz-Gly+Lys	S		-	-	Bz	Gly	Lys	-	-	-	Skidgel et al., 1989
Dns-Ala-Arg			Dns-Ala+Arg	S		-	-	Dns	Ala	Arg	-	-	-	Skidgel et al., 1989
dynorphin A(1-13)	P01214	209-221	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu+Lys	N		Arg	Pro	Lys	Leu	Lys	-	-	-	Skidgel, 2004
hemoglobin subunit alpha	P69905	2-142	peptide-Tyr141+Arg	P		Thr	Ser	Lys	Tyr	Arg	-	-	-	Michel et al., 1996	3094
pro-epidermal growth factor	P01133	971-1023	peptide-Leu1022+Arg	P	NT	Trp	Trp	Glu	Leu	Arg	-	-	-	Skidgel et al., 1997	3093
stromal cell-derived factor 1	P48061	22-93	peptide-Asn88+Lys	P		Lys	Ala	Leu	Asn	Lys	-	-	-	Marquez-Curtis et al., 2008
[Leu5]-enkephalin-Arg	P01213	175-180	Tyr-Gly-Gly-Phe-Leu+Arg	N		Gly	Gly	Phe	Leu	Arg	-	-	-	Skidgel, 2004
[Met5]-enkephalin-Lys			Tyr-Gly-Gly-Phe-Met+Lys	N		Gly	Gly	Phe	Met	Lys	-	-	-	Skidgel, 2004