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Substrates for peptidase S01.161: kallikrein-related peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Arg-Arg-NHMec Ala-Arg-Arg+NHMec S - Ala Arg Arg AMC - - - Lovgren et al., 1999
alpha-1-antichymotrypsin P01011 24-423 peptide-Leu383+Ser-peptide P Ile Thr Leu Leu Ser Ala Leu Val Mikolajczyk et al., 1999 3382
D-Pro-Phe-Arg-NHPhNO2 D-Pro-Phe-Arg+NHPhNO2 S - DPr Phe Arg NAN - - - Mikolajczyk et al., 1998
fibronectin P02751 32-2386 peptide-Arg290+Ala-peptide P Thr Asp Val Arg Ala Ala Val Tyr Deperthes et al., 1996 20423
fibronectin P02751 32-2386 peptide-Arg2059+Thr-peptide P Gly Phe Arg Arg Thr Thr Pro Pro Deperthes et al., 1996 20413
gurmarin P25810 1-35 peptide-Tyr13+Tyr-peptide P Cys Ile Pro Tyr Tyr Leu Asp Cys Yamada et al., 2006 20217
insulin-like growth factor-binding protein 2 P18065 40-328 peptide-Arg200+Gln-peptide P MS Glu Gln His Arg Gln Met Gly Lys Rehault et al., 2001 20390
Kallikrein-1 precursor P06870 19-262 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Yoon et al., 2007 17295
Kallikrein-11 precursor Q9UBX7 51-282 Glu-Thr-Arg53+Ile-peptide P NT - Glu Thr Arg Ile Ile Lys Gly Yoon et al., 2007
Kallikrein-12 precursor Q9UKR0 18-248 Ala-Thr-Pro-Lys21+Ile-peptide P NT Ala Thr Pro Lys Ile Phe Asn Gly Yoon et al., 2007
Kallikrein-13 precursor Q9UKR3 17-277 peptide-Lys25+Val-peptide P NT Glu Ser Ser Lys Val Leu Asn Thr Yoon et al., 2007
Kallikrein-5 precursor Q9Y337 23-293 peptide-Arg66+Ile-peptide P NT Ser Ser Ser Arg Ile Ile Asn Gly Yoon et al., 2007
Kallikrein-6 precursor Q92876 17-244 peptide-Lys21+Leu-peptide P NT Glu Gln Asn Lys Leu Val His Gly Yoon et al., 2007
Kallikrein-9 precursor Q9UKQ9 16-250 peptide-Arg22+Ala-peptide P NT Ala Asp Thr Arg Ala Ile Gly Ala Yoon et al., 2007
kallikrein-related peptidase 11 isoform 2 Q9UBX7 51-282 peptide-Arg188+Leu-peptide P Pro Gln Leu Arg Leu Pro His Thr Luo et al., 2006 20973
kallikrein-related peptidase 2 P20151 19-261 Pro-Leu-Ile-Gln-Ser-Arg+Ile-peptide P Ile Gln Ser Arg Ile Val Gly Gly Mikolajczyk et al., 1998 21002
kallikrein-related peptidase 2, prostatic isoform 1 P20151 1-261 peptide-Arg169+Ser-peptide P Leu Arg Pro Arg Ser Leu Gln Cys Väisänen et al., 2002 20232
kallikrein-related peptidase 2, prostatic isoform 1 P20151 234-260 peptide-Arg250+Lys-peptide N Val His Tyr Arg Lys Trp Ile Lys Mikolajczyk et al., 1998 21003
kallikrein-related peptidase 3 P07288 17-261 peptide-Arg24+Ile-peptide P Ile Leu Ser Arg Ile Val Gly Gly Takayama et al., 1997 20239
kininogen-1 P01042 19-644 peptide-Lys362+Arg-peptide P Ser Leu Met Lys Arg Pro Pro Gly 17293
kininogen-1 P01042 19-644 peptide-Arg371+Ser-peptide P Ser Pro Phe Arg Ser Ser Arg Ile 17294
kininogen-1 P01042 19-644 peptide-Arg427+Arg-peptide P Gly His Thr Arg Arg His Asp Trp Charlesworth et al., 1999 21064
kininogen-1 P01042 19-644 peptide-Arg437+Lys-peptide P Glu Lys Gln Arg Lys His Asn Leu Charlesworth et al., 1999 21065
kininogen-1 P01042 19-644 peptide-Arg457+Gly-peptide P Gly His Gln Arg Gly His Gly Leu Charlesworth et al., 1999 21066
phage display clone 5.10 Ile-Gly-Gly-Gly-Ile-Met-Ser-Arg+Gln-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Ile Met Ser Arg Gln Gly Ser Thr Cloutier et al., 2002
phage display clone 5.14 Ile-Gly-Gly-Gly-Arg+Asn-Asp-Lys-Leu-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Gly Arg Asn Asp Lys Leu Cloutier et al., 2002
phage display clone 5.18 Ile-Gly-Gly-Gly-Glu-Arg+Val-Ser-Pro-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Glu Arg Val Ser Pro Gly Cloutier et al., 2002
phage display clone 5.19 Ile-Gly-Gly-Gly-Thr-Leu-Gln-Arg+Val-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Thr Leu Gln Arg Val Gly Ser Thr Cloutier et al., 2002
phage display clone 5.3 Ile-Gly-Gly-Gly-Thr-Arg+Ala-Pro-Met-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Thr Arg Ala Pro Met Gly Cloutier et al., 2002
phage display clone 5.4 Ile-Gly-Gly-Gly-Thr-Gly-Ser-Arg+Asp-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Thr Gly Ser Arg Asp Gly Ser Thr Cloutier et al., 2002
phage display clone 5.5 Ile-Gly-Gly-Gly-Glu-Thr-Lys-Arg+Ser-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Glu Thr Lys Arg Ser Gly Ser Thr Cloutier et al., 2002
phage display clone 5.7 Ile-Gly-Gly-Gly-Ser-Gly-Arg+Leu-Ala-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Ser Gly Arg Leu Ala Gly Ser Cloutier et al., 2002
phage display clone 6.1 Ile-Gly-Gly-Gly-Met-Thr-Arg+Ser-Asn-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Met Thr Arg Ser Asn Gly Ser Cloutier et al., 2002
phage display clone 6.12 Ile-Gly-Gly-Gly-Gly-Thr-Leu-Arg+Phe-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Thr Leu Arg Phe Gly Ser Thr Cloutier et al., 2002
phage display clone 6.14 Ile-Gly-Gly-Gly-Arg-Gly-Arg+Met-Ala-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Arg Gly Arg Met Ala Gly Ser Cloutier et al., 2002
phage display clone 6.15 Ile-Gly-Gly-Gly-Val-Arg+Pro-Leu-Glu-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Val Arg Pro Leu Glu Gly Cloutier et al., 2002
phage display clone 6.19 Ile-Gly-Gly-Gly-Gly-Val-Phe-Arg+Ser-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Val Phe Arg Ser Gly Ser Thr Cloutier et al., 2002
phage display clone 6.2 Ile-Gly-Gly-Gly-Arg-Arg+Ser-Ile-Asp-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Arg Arg Ser Ile Asp Gly Cloutier et al., 2002
phage display clone 6.20 Ile-Gly-Gly-Gly-Ala-Arg+Ala-Ser-Glu-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Ala Arg Ala Ser Glu Gly Cloutier et al., 2002
phage display clone 6.3 Ile-Gly-Gly-Gly-Leu-Thr-Thr-Ser-Lys+Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Thr Thr Ser Lys Gly Ser Thr Gly Cloutier et al., 2002
phage display clone 6.4 Ile-Gly-Gly-Gly-Pro-Ser-Ala-Arg+Met-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Pro Ser Ala Arg Met Gly Ser Thr Cloutier et al., 2002
phage display clone 6.5 Ile-Gly-Gly-Gly-Thr-Val-Arg+Met-Pro-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Thr Val Arg Met Pro Gly Ser Cloutier et al., 2002
phage display clone 6.6 Ile-Gly-Gly-Gly-Lys-Thr-Arg+Ser-Asn-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Lys Thr Arg Ser Asn Gly Ser Cloutier et al., 2002
phage display clone 6.7 Ile-Gly-Gly-Gly-Lys-Leu-Arg+Thr-Thr-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Lys Leu Arg Thr Thr Gly Ser Cloutier et al., 2002
phage display clone 8.11 Ile-Gly-Gly-Gly-Val-Leu-Arg+Ser-Pro-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Val Leu Arg Ser Pro Gly Ser Cloutier et al., 2002
phage display clone 8.12 Ile-Gly-Gly-Gly-Leu-Arg+Met-Pro-Thr-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Leu Arg Met Pro Thr Gly Cloutier et al., 2002
phage display clone 8.17 Ile-Gly-Gly-Gly-Pro-Gly-Arg+Ala-Pro-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Pro Gly Arg Ala Pro Gly Ser Cloutier et al., 2002
phage display clone 8.19 Ile-Gly-Gly-Gly-Thr-Arg-Asp-Ser-Arg-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Thr Arg Asp Ser Arg Gly Cloutier et al., 2002
phage display clone 8.20 Ile-Gly-Gly-Gly-Leu-Arg+Ser-Arg-Ala-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Gly Leu Arg Ser Arg Ala Gly Cloutier et al., 2002
phage display clone 8.3 Ile-Gly-Gly-Gly-Arg-Gly-Arg+Ser-Glu-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Arg Gly Arg Ser Glu Gly Ser Cloutier et al., 2002
phage display clone 8.9 Ile-Gly-Gly-Gly-Ala-Arg-Ala-Arg+Ser-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Ala Arg Ala Arg Ser Gly Ser Thr Cloutier et al., 2002
phage display clone PCI Ile-Gly-Gly-Gly-Thr-Phe-Arg+Ser-Ala-Gly-Ser-Thr-Gly-Gly-Gly-Ser-His-His-His-His-His-His S Gly Thr Phe Arg Ser Ala Gly Ser Cloutier et al., 2002
plasma serine protease inhibitor P05154 20-406 peptide-Arg373+Ser-peptide P Phe Thr Phe Arg Ser Ala Arg Leu Mikolajczyk et al., 1999 3381
plasminogen activator inhibitor-1 P05121 24-402 peptide-Arg369+Met-peptide P Val Ser Ala Arg Met Ala Pro Glu Mikolajczyk et al., 1999
Pro-Phe-Arg-NHMec Pro-Phe-Arg+NHMec S - Pro Phe Arg AMC - - - Lovgren et al., 1999
semenogelin-1 P04279 24-462 peptide-Arg137+Gly-peptide P Lys Ala His Arg Gly Thr Gln Asn Lovgren et al., 1999 20650
semenogelin-1 P04279 24-462 peptide-Arg297+Leu-peptide P Glu Glu Arg Arg Leu His Tyr Gly Lovgren et al., 1999 20652
semenogelin-1 P04279 24-462 peptide-Arg372+Ser-peptide P Val Ser Gln Arg Ser Ile Tyr Ser Lovgren et al., 1999 20653
semenogelin-2 Q02383 24-582 peptide-His124+Met-peptide P Gly His Phe His Met Ile Val Ile Lovgren et al., 1999 3384
semenogelin-2 Q02383 24-582 peptide-Arg165+Leu-peptide P Thr Glu Lys Arg Leu Trp Val His Lovgren et al., 1999 3385
semenogelin-2 Q02383 24-582 peptide-Arg245+Leu-peptide P His Gln Asp Arg Leu Gln His Gly Lovgren et al., 1999 3386
semenogelin-2 Q02383 24-582 peptide-Arg292+Thr-peptide P Pro Ser Ser Arg Thr Glu Glu Arg Lovgren et al., 1999 3387
semenogelin-2 Q02383 24-582 peptide-Arg391+Ile-peptide P Asn Gln Val Arg Ile Pro Ser Gln Lovgren et al., 1999 3388
semenogelin-2 Q02383 24-582 peptide-Arg477+Leu-peptide P Glu Glu Arg Arg Leu Asn Tyr Gly Lovgren et al., 1999 3389
semenogelin-2 Q02383 24-582 peptide-Arg545+Tyr-peptide P Gln Lys Gly Arg Tyr Lys Gln Glu Lovgren et al., 1999 3390
urokinase-type plasminogen activator P00749 21-431 peptide-Lys158+Ile-peptide P Pro Arg Phe Lys Ile Ile Gly Gly 17296

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