Substrates for peptidase M03.005: peptidyl-dipeptidase Dcp

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Abz-Leu-Phe-Lys(Dnp)			Abz-Leu+Phe-Lys(Dnp)	S	-	-	Abz	Leu	Phe	Lyd	-	-	Cunha et al., 2009
Abz-Phe-Arg-Ala-Lys(Dnp)			Abz-Phe-Arg+Ala-Lys(Dnp)	S	-	Abz	Phe	Arg	Ala	Lyd	-	-	Cunha et al., 2009
Abz-Phe-Arg-Lys(Dnp)-Pro			Abz-Phe-Arg+Lys(Dnp)-Pro	S	-	Abz	Phe	Arg	Lyd	Pro	-	-	Cunha et al., 2009
Ac-Ala-Ala-Ala			Ac-Ala+Ala-Ala	S	-	-	Ac	Ala	Ala	Ala	-	-	Henrich & Klein, 2004
angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His-Leu	N	Ile	His	Pro	Phe	His	Leu	-	-	Cunha et al., 2009
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg	N	Gly	Phe	Ser	Pro	Phe	Arg	-	-	Cunha et al., 2009
bradykinin 1-7	P01042	381-387	Arg-Pro-Pro-Gly-Phe+Ser-Pro	N	Pro	Pro	Gly	Phe	Ser	Pro	-	-	Cunha et al., 2009
Bz-Gly-His-Leu			Bz-Gly+His-Leu	S	-	-	Bz	Gly	His	Leu	-	-	Henrich & Klein, 2004