Substrates for peptidase M01.011: cystinyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ala-NHNap			Ala+NHNap	S		-	-	-	Ala	NAP	-	-	-	Nomura et al., 2004
angiotensin-3	P01019	35-41	Arg+Val-Tyr-Ile-His-Pro-Phe	P		-	-	-	Arg	Val	Tyr	Ile	His	Keller, 1998	16411
angiotensin-4	P01019	36-41	Val+Tyr-Ile-His-Pro-Phe	P		-	-	-	Val	Tyr	Ile	His	Pro	Keller, 1998	16412
Arg-NHNap			Arg+NHNap	S		-	-	-	Arg	NAP	-	-	-	Nomura et al., 2004
Leu-enkephalin	P01213	175-179	Tyr175+Gly-Gly-Phe-Leu	P	NT	-	-	-	Tyr	Gly	Gly	Phe	Leu	Ye et al., 2008
Leu-NHNap			Leu+NHNap	S		-	-	-	Leu	NAP	-	-	-	Nomura et al., 2004
Leu-NHPhNO2			Leu+NHPhNO2	S		-	-	-	Leu	NAN	-	-	-	Nomura et al., 2004
Lys-NHNap			Lys+NHNap	S		-	-	-	Lys	NAP	-	-	-	Keller, 1998
oxytocin	P01178	20-28	Cys+Tyr-peptide	N		-	-	-	Cys	Tyr	Ile	Gln	Asn	Nomura et al., 2004	16413
vasopressin	P01185	20-28	Cys+Tyr-peptide	P		-	-	-	Cys	Tyr	Phe	Gln	Asn	Wallis et al., 2007	16414
[Lys]-bradykinin (kallidin)	P01042	380-389	Lys+Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg	N		-	-	-	Lys	Arg	Pro	Pro	Gly	Keller, 1998