Substrates for peptidase M03.010: Pz-peptidase A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
bradykinin P01042 381-389 Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg N Pro Pro Gly Phe Ser Pro Phe Arg Pritchard, 2004 16439
furylacryloyl-Leu-Gly-Pro-Ala furylacryloyl-Leu+Gly-Pro-Ala S - - FA Leu Gly Pro Ala - Miyake et al., 2005
hypertensin Asn-Arg-Val-Tyr-Val+His-Pro-Phe N Arg Val Tyr Val His Pro Phe - Miyake et al., 2005
Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp) Mcc-Pro-Leu+Gly-Pro-D-Lys(Dnp) S - Mcc Pro Leu Gly Pro Lyd - Sugihara et al., 2007
neurotensin P30990 151-163 Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg+Arg-Pro-Tyr-Ile-Leu N Asn Lys Pro Arg Arg Pro Tyr Ile Miyake et al., 2005
neurotensin P30990 151-163 Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Leu N Pro Arg Arg Pro Tyr Ile Leu - Miyake et al., 2005
Pz-Pro-Leu-Gly-Pro-D-Arg Pz-Pro-Leu+Gly-Pro-D-Arg S - Pz Pro Leu Gly Pro Arg - Miyake et al., 2005
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln+Gln-Phe-Phe-Gly-Leu-Met N Pro Lys Pro Gln Gln Phe Phe Gly Miyake et al., 2005
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln+Phe-Phe-Gly-Leu-Met N Lys Pro Gln Gln Phe Phe Gly Leu Miyake et al., 2005
[Gly-Pro-Leu]2 Gly-Pro-Leu+Gly-Pro-Leu S - Gly Pro Leu Gly Pro Leu - Miyake et al., 2005
[Gly-Pro-Leu]3 Gly-Pro-Leu+Gly-Pro-Leu-Gly-Pro-Leu S - Gly Pro Leu Gly Pro Leu Gly Miyake et al., 2005
[Gly-Pro-Leu]3 Gly-Pro-Leu-Gly-Pro-Leu+Gly-Pro-Leu S Leu Gly Pro Leu Gly Pro Leu - Miyake et al., 2005
[Gly-Pro-Leu]4 Gly-Pro-Leu+Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu S - Gly Pro Leu Gly Pro Leu Gly Miyake et al., 2005