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Substrates for peptidase M28.002: aminopeptidase Ap1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Arg-Ala Arg+Ala S AA - - - Arg Ala - - - Wilkes et al., 1973
Asn-Thr Asn+Thr S AA - - - Asn Thr - - - Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Leu17+Ile-peptide N AA - - - Leu Ile Val Thr Gln Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Ile18+Val-peptide N AA - - - Ile Val Thr Gln Thr Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Val19+Thr-peptide N AA - - - Val Thr Gln Thr Met Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Thr20+Gln-peptide N AA - - - Thr Gln Thr Met Lys Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Gln21+Thr-peptide N AA - - - Gln Thr Met Lys Gly Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Thr22+Met-peptide N AA - - - Thr Met Lys Gly Leu Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Met23+Lys-peptide N AA - - - Met Lys Gly Leu Asp Wilkes et al., 1973
beta-lactoglobulin P02754 17-178 Lys24+Gly-peptide N AA - - - Lys Gly Leu Asp Ile Wilkes et al., 1973
corticotropin P01189 138-176 Ser+Tyr-peptide N AA - - - Ser Tyr Ser Met Glu Wilkes et al., 1973
gastrin P01350 89-92 Trp+Met-Asp-Phe-NH2 N AA - - - Trp Met Asp Phe NH2 Wilkes et al., 1973
gastrin P01350 90-92 Met+Asp-Phe-NH2 N AA - - - Met Asp Phe NH2 - Wilkes et al., 1973
Gln-Trp-Leu-Met-Asn-Thr Gln+Trp-Leu-Met-Asn-Thr S AA - - - Gln Trp Leu Met Asn Wilkes et al., 1973
glucagon P01274 53-81 His+Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser+Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N AA - - - His Ser Gln Gly Thr Wilkes et al., 1973
glucagon (2-29) P01274 54-81 Ser+Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser+Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N AA - - - Ser Gln Gly Thr Phe Wilkes et al., 1973
glucagon (3-29) P01274 55-81 Gln+Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser+Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N AA - - - Gln Gly Thr Phe Thr Wilkes et al., 1973
glucagon (4-29) P01274 56-81 Gly+Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser+Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N AA - - - Gly Thr Phe Thr Ser Wilkes et al., 1973
glucagon (5-29) P01274 57-81 Thr+Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N AA - - - Thr Phe Thr Ser Asp Wilkes et al., 1973
glucagon (6-29) P01274 58-81 Phe+Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser+Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N AA - - - Phe Thr Ser Asp Tyr Wilkes et al., 1973
glucagon (7-29) P01274 59-81 Thr+Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N AA - - - Thr Ser Asp Tyr Ser Wilkes et al., 1973
insulin B chain (oxidized) (10-30) P01317 34-54 His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - His Leu Val Glu Ala Wilkes et al., 1973
insulin B chain (oxidized) (11-30) P01317 35-54 Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Leu Val Glu Ala Leu Wilkes et al., 1973
insulin B chain (oxidized) (2-30) P01317 36-54 Val+Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Val Asn Gln His Leu Wilkes et al., 1973
insulin B chain (oxidized) (3-30) P01317 37-54 Asn+Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Asn Gln His Leu Cya Wilkes et al., 1973
insulin B chain (oxidized) (4-30) P01317 38-54 Gln+His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Gln His Leu Cya Gly Wilkes et al., 1973
insulin B chain (oxidized) (5-30) P01317 39-54 His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - His Leu Cya Gly Ser Wilkes et al., 1973
insulin B chain (oxidized) (6-30) P01317 40-54 Leu+Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Leu Cya Gly Ser His Wilkes et al., 1973
insulin B chain (oxidized) (7-30) P01317 41-54 Cya+Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Cya Gly Ser His Leu Wilkes et al., 1973
insulin B chain (oxidized) (8-30) P01317 42-54 Gly+Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Gly Ser His Leu Val Wilkes et al., 1973
insulin B chain (oxidized) (9-30) P01317 43-54 Ser+His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Ser His Leu Val Glu Wilkes et al., 1973
insulin B-chain (oxidized) P01317 25-54 Phe+Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N AA - - - Phe Val Asn Gln His Wilkes et al., 1973
Leu-Arg Leu+Arg S - - - Leu Arg - - - Arima et al., 2006
Leu-His Leu+His S - - - Leu His - - - Arima et al., 2006
Leu-Leu Leu+Leu S - - - Leu Leu - - - Arima et al., 2006
Leu-Met-Asn-Thr Leu+Met-Asn-Thr S AA - - - Leu Met Asn Thr - Wilkes et al., 1973
Leu-NH2 Leu+NH2 S - - - Leu NH2 - - - Arima et al., 2006
Leu-NHPhNO2 Leu+NHPhNO2 S - - - Leu NAN - - - Arima et al., 2006
Leu-Phe Leu+Phe S - - - Leu Phe - - - Arima et al., 2006
Leu-Trp Leu+Trp S - - - Leu Trp - - - Arima et al., 2006
Leu-Trp-Met-Phe-Arg-Ala Leu+Trp-Met-Phe-Arg-Ala S AA - - - Leu Trp Met Phe Arg Wilkes et al., 1973
Leu-Tyr Leu+Tyr S - - - Leu Tyr - - - Arima et al., 2006
lysozyme C P00698 19-147 Lys19+Val-peptide N AA - - - Lys Val Phe Gly Arg Wilkes et al., 1973
lysozyme C P00698 19-147 Val20+Phe-peptide N AA - - - Val Phe Gly Arg Cys Wilkes et al., 1973
lysozyme C P00698 19-147 Phe21+Gly-peptide N AA - - - Phe Gly Arg Cys Glu Wilkes et al., 1973
lysozyme C P00698 19-147 Gly22+Arg-peptide N AA - - - Gly Arg Cys Glu Leu Wilkes et al., 1973
lysozyme C P00698 19-147 Arg23+Cys-peptide N AA - - - Arg Cys Glu Leu Ala Wilkes et al., 1973
Met-Asn-Thr Met+Asn-Thr S AA - - - Met Asn Thr - - Wilkes et al., 1973
Met-Phe-Arg-Ala Met+Phe-Arg-Ala S AA - - - Met Phe Arg Ala - Wilkes et al., 1973
myoglobin P02185 2-154 Val2+Leu-peptide N AA - - - Val Leu Ser Glu Gly Wilkes et al., 1973
myoglobin P02185 2-154 Leu3+Ser-peptide N AA - - - Leu Ser Glu Gly Glu Wilkes et al., 1973
myoglobin P02185 2-154 Ser4+Glu-peptide N AA - - - Ser Glu Gly Glu Trp Wilkes et al., 1973
Phe-Arg-Ala Phe+Arg-Ala S AA - - - Phe Arg Ala - - Wilkes et al., 1973
Phe-Asp-Ser-Ala-Val Phe+Asp-Ser-Ala-Val S AA - - - Phe Asp Ser Ala Val Wilkes et al., 1973
Phe-Phe Phe+Phe S - - - Phe Phe - - - Arima et al., 2006
Phe-Phe-Phe Phe+Phe-Phe S - - - Phe Phe Phe - - Arima et al., 2006
Phe-Val-Gln-Trp-Leu-Met-Asn-Thr Phe+Val-Gln-Trp-Leu-Met-Asn-Thr S AA - - - Phe Val Gln Trp Leu Wilkes et al., 1973
ribonuclease, pancreatic P61823 27-150 Lys27+Glu-peptide N AA - - - Lys Glu Thr Ala Ala Wilkes et al., 1973
Trp-Leu-Met-Asn-Thr Trp+Leu-Met-Asn-Thr S AA - - - Trp Leu Met Asn Thr Wilkes et al., 1973
Trp-Met-Phe-Arg-Ala Trp+Met-Phe-Arg-Ala S AA - - - Trp Met Phe Arg Ala Wilkes et al., 1973
Val-Gln-Trp-Leu-Met-Asn-Thr Val+Gln-Trp-Leu-Met-Asn-Thr S AA - - - Val Gln Trp Leu Met Wilkes et al., 1973
[desSer1,Tyr2,Ser3]-corticotropin P01189 141-176 Met+Glu-peptide N AA - - - Met Glu His Phe Arg Wilkes et al., 1973
[desSer1,Tyr2]-corticotropin P01189 140-176 Ser+Met-peptide N AA - - - Ser Met Glu His Phe Wilkes et al., 1973
[desSer1]-corticotropin P01189 139-176 Tyr+Ser-peptide N AA - - - Tyr Ser Met Glu His Wilkes et al., 1973
[Lys]-bradykinin (kallidin) P01042 380-389 Lys+Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg N AA - - - Lys Arg Pro Pro Gly Wilkes et al., 1973
[Met-Lys]-bradykinin P01042 379-389 Met+Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg N AA - - - Met Lys Arg Pro Pro Wilkes et al., 1973

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