Substrates for peptidase M24.009: aminopeptidase P1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Pro Ala+Pro N - - - Ala Pro - - - Harbeck & Mentlein, 1991
Arg-Pro Arg+Pro N - - - Arg Pro - - - Harbeck & Mentlein, 1991
Arg-Pro-NHPhNO2 Arg+Pro-NHPhNO2 S - - - Arg Pro NAN - - Harbeck & Mentlein, 1991
Arg-Pro-Pro Arg+Pro-Pro N - - - Arg Pro Pro - - Harbeck & Mentlein, 1991
beta-casomorphin Tyr+Pro-Phe-Pro-Gly-Pro-Ile N - - - Tyr Pro Phe Pro Gly Harbeck & Mentlein, 1991
beta-casomorphin 1-5 Tyr+Pro-Phe-Pro-Gly N - - - Tyr Pro Phe Pro Gly Harbeck & Mentlein, 1991
bradykinin P01042 381-389 Arg+Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg N - - - Arg Pro Pro Gly Phe Harbeck & Mentlein, 1991 17071
bradykinin 1-5 P01042 381-385 Arg+Pro-Pro-Gly-Phe N - - - Arg Pro Pro Gly Phe Harbeck & Mentlein, 1991 17071
Gly-Pro-Arg-Pro Gly+Pro-Arg-Pro N - - - Gly Pro Arg Pro - Harbeck & Mentlein, 1991
Gly-Pro-Hyp Gly+Pro-Hyp S - - - Gly Pro Hyp - - Turner & Cottrell, 2004
His-Pro-Val His-Pro-Val N - - - His Pro Val - - Harbeck & Mentlein, 1991
Lys-Pro Lys+Pro N - - - Lys Pro - - - Harbeck & Mentlein, 1991
Neuropeptide Y P01303 29-64 Tyr29+Pro-peptide P MS - - - Tyr Pro Ser Lys Pro Frerker et al., 2007
Phe-Pro-Ala-NHNap Phe+Pro-Ala-NHNap S - - - Phe Pro Ala NAP - Harbeck & Mentlein, 1991
Phe-Pro-NHNap Phe+Pro-NHNap S - - - Phe Pro NAP - - Harbeck & Mentlein, 1991
substance P 1-4 P20366 58-61 Arg+Pro-Lys-Pro N - - - Arg Pro Lys Pro - Harbeck & Mentlein, 1991 17072
Tyr-Pro-Phe-HN2 Tyr+Pro-Phe-HN2 N - - - Tyr Pro Phe - - Harbeck & Mentlein, 1991
[Tyr1]-melanostatin Tyr+Pro-Leu-Gly-NH2 N - - - Tyr Pro Leu Gly - Harbeck & Mentlein, 1991