Substrates for peptidase S01.033: factor VII-activating peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ala-Leu-Lys-Arg-NHMec			Ala-Leu-Lys-Arg+NHMec	S		Ala	Leu	Lys	Arg	AMC	-	-	-	Kara et al., 2017
Ala-Lys-Nle-Arg-NHMec			Ala-Lys-Nle-Arg+NHMec	S		Ala	Lys	Nle	Arg	AMC	-	-	-	Kara et al., 2017
coagulation factor VII	P08709	61-466	peptide-Arg212+Ile-peptide	P	CS	Pro	Gln	Gly	Arg	Ile	Val	Gly	Gly	R”misch et al., 1999
fibrinogen, beta chain	P02675	31-44	peptide-Lys83+Lys-peptide	P		Ala	Thr	Gln	Lys	Lys	Val	Glu	Arg	Choi-Miura et al., 2001	21692
Hyaluronan-binding protein 2	Q14520	24-560	Peptide-Arg313+Ile-Peptide	P	NT	Lys	Ile	Lys	Arg	Ile	Tyr	Gly	Gly	Choi-Miura et al., 2001
Hyaluronan-binding protein 2	Q14520	24-560	Peptide-Lys319+Ser-Peptide	P	NT	Gly	Gly	Phe	Lys	Ser	Thr	Ala	Gly	Choi-Miura et al., 2001
Hyaluronan-binding protein 2	Q14520	24-560	Peptide-Arg170+Arg-Peptide	P	NT	Arg	His	Lys	Arg	Arg	Ser	Lys	Phe	Choi-Miura et al., 2001
Hyaluronan-binding protein 2	Q14520	24-560	Peptide-Arg171+Ser-Peptide	P	NT	His	Lys	Arg	Arg	Ser	Lys	Phe	Thr	Choi-Miura et al., 2001
Hyaluronan-binding protein 2	Q14520	24-560	Peptide-Arg480+Gln-Peptide	P	NT	Cys	Asn	Ser	Arg	Gln	Leu	Tyr	Asp	Choi-Miura et al., 2001
kininogen-1	P01042	19-644	peptide-Arg437+Lys-peptide	P	NT	Glu	Lys	Gln	Arg	Lys	His	Asn	Leu	Etscheid et al., 2002
kininogen-1	P01042	19-644	peptide-Arg389+Ser-peptide	P	NT	Ser	Pro	Phe	Arg	Ser	Ser	Arg	Ile	Etscheid et al., 2002
kininogen-1	P01042	19-644	peptide-Arg381+Pro-peptide	P	MS	Leu	Met	Lys	Arg	Pro	Pro	Gly	Phe	Etscheid et al., 2002
phage display peptide			peptide-Val-Leu-Lys-Arg+Ser-peptide	N		Val	Leu	Lys	Arg	Ser	CPe	-	-	Kara et al., 2017
S-2288			D-Ile-Pro-Arg+NHPhNO2	S		-	DIl	Pro	Arg	NAN	-	-	-	Etscheid & Dodt, 2004
vascular endothelial growth factor A	P15692	27-232	peptide-Arg191+Lys-peptide	N		Ser	Glu	Arg	Arg	Lys	His	Leu	Phe	Kunnapuu et al., 2021