Substrates for peptidase M24.005: aminopeptidase P2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
aminoacylproline Xaa+Pro N - - - Xaa Pro - - - Simmons, 2004
Arg-Pro-Pro Arg+Pro-Pro N - - - Arg Pro Pro - - Molinaro et al., 2005
Arg-Pro-Pro-benzylamide Arg+Pro-Pro-benzylamide S - - NPe Arg Pro Pro BzN - Simmons, 2004
bradykinin P01042 381-389 Arg+Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg N - - - Arg Pro Pro Gly Phe Molinaro et al., 2005 17069
Gly-Pro-Hyp Gly+Pro-Hyp N - - - Gly Pro Hyp - - Simmons, 2004
Gly-Pro-Pro-NHNap Gly+Pro-Pro-NHNap S - - - Gly Pro Pro NAP - Simmons, 2004
Gly-Pro-Pro-NHPhNO2 Gly+Pro-Pro-NHPhNO2 S - - - Gly Pro Pro NAN - Simmons, 2004
K(Dnp)PPGFSPK(Abz)NH2 Lys(Dnp)+Pro-Pro-Gly-Phe-Ser-Pro-Lys(Abz)NH2 S - - - Lyd Pro Pro Gly Phe Molinaro et al., 2005
K(Dnp)PPGK(Abz)NH2 Lys(Dnp)+Pro-Pro-Gly-Lys(Abz)NH2 S - - - Lyd Pro Pro Gly Lya Molinaro et al., 2005
K(Dnp)PPK(Abz)NH2 Lys(Dnp)+Pro-Pro-Lys(Abz)NH2 S - - - Lyd Pro Pro Lya NH2 Molinaro et al., 2005
Lys(epsilon-Abz)-Pro-Pro-NHPhNO2 Lys(epsilon-Abz)+Pro-Pro-NHPhNO2 S - - - Lya Pro Pro NAN - Simmons, 2004
Lys(epsilon-Dnp)-Pro-Pro Lys(epsilon-Dnp)+Pro-Pro-NH-CH2-CH2-NH-Abz S - - - Lyd Pro Pro CBk - Simmons, 2004
neuropeptide Y P01303 29-64 Tyr+Pro-peptide P - - - Tyr Pro Ser Lys Pro Simmons, 2004 17070