Substrates for family S10 unassigned peptidases

Summary Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Angiotensin 1-3	P01019	34-36	Asp-Arg35+Val	N	NT	-	-	Asp	Arg	Val	-	-	-	Umetsu et al., 1998
Angiotensin 1-4	P01019	34-37	Asp-Arg-Val36+Tyr	N	NT	-	Asp	Arg	Val	Tyr	-	-	-	Umetsu et al., 1998
Angiotensin 1-5	P01019	34-38	Asp-Arg-Val-Tyr37+Ile	N	NT	Asp	Arg	Val	Tyr	Ile	-	-	-	Umetsu et al., 1998
Angiotensin 1-6	P01019	34-39	Peptide-Ile38+His	N	NT	Arg	Val	Tyr	Ile	His	-	-	-	Umetsu et al., 1998
Angiotensin 1-7	P01019	34-40	Peptide-His39+Pro	N	NT	Val	Tyr	Ile	His	Pro	-	-	-	Umetsu et al., 1998
Angiotensin 1-9	P01019	34-42	Peptide-Phe41+His	N	NT	Ile	His	Pro	Phe	His	-	-	-	Umetsu et al., 1998
Angiotensin-1	P01019	34-43	Peptide-His42+Leu	N	NT	His	Pro	Phe	His	Leu	-	-	-	Umetsu et al., 1998
Angiotensin-2	P01019	34-41	Peptide-Pro40+Phe	N	NT	Tyr	Ile	His	Pro	Phe	-	-	-	Umetsu et al., 1998
Bradykinin	P01042	381-386	Peptide-Phe385+Ser	N	NT	Pro	Pro	Gly	Phe	Ser	-	-	-	Umetsu et al., 1998
Bradykinin	P01042	381-387	Peptide-Ser386+Pro	N	NT	Pro	Gly	Phe	Ser	Pro	-	-	-	Umetsu et al., 1998
Bradykinin	P01042	381-388	Peptide-Pro387+Phe	N	NT	Gly	Phe	Ser	Pro	Phe	-	-	-	Umetsu et al., 1998
Bradykinin	P01042	381-389	Peptide-Phe388+Arg	N	NT	Phe	Ser	Pro	Phe	Arg	-	-	-	Umetsu et al., 1998
Delta sleep-inducing peptide	P01158	1-5	Trp-Ala-Gly-Gly4+Asp	N	NT	Trp	Ala	Gly	Gly	Asp	-	-	-	Umetsu et al., 1998
Delta sleep-inducing peptide	P01158	1-6	Peptide-Asp5+Ala	N	NT	Ala	Gly	Gly	Asp	Ala	-	-	-	Umetsu et al., 1998
Delta sleep-inducing peptide	P01158	1-7	Peptide-Ala6+Ser	N	NT	Gly	Gly	Asp	Ala	Ser	-	-	-	Umetsu et al., 1998
Delta sleep-inducing peptide	P01158	1-8	Peptide-Ser7+Gly	N	NT	Gly	Asp	Ala	Ser	Gly	-	-	-	Umetsu et al., 1998
Delta sleep-inducing peptide	P01158	1-9	Peptide-Gly8+Glu	N	NT	Asp	Ala	Ser	Gly	Glu	-	-	-	Umetsu et al., 1998
Eledoisin	P62933	7-11	Phe-Ile-Gly-Leu10+Met-NH2	N	NT	Phe	Ile	Gly	Leu	Met	NH2	-	-	Umetsu et al., 1998
FMRFamide	P69145	1-4	Phe-Met-Arg3+Phe-NH2	N	NT	-	Phe	Met	Arg	Phe	NH2	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-153	Gln-Leu152+Tyr	N	NT	-	-	Gln	Leu	Tyr	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-154	Gln-Leu-Tyr153+Glu	N	NT	-	Gln	Leu	Tyr	Glu	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-155	Gln-Leu-Tyr-Glu154+Asn	N	NT	Gln	Leu	Tyr	Glu	Asn	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-156	Peptide-Asn155+Lys	N	NT	Leu	Tyr	Glu	Asn	Lys	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-157	Peptide-Lys156+Pro	N	NT	Tyr	Glu	Asn	Lys	Pro	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-158	Peptide-Pro157+Arg	N	NT	Glu	Asn	Lys	Pro	Arg	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-159	Peptide-Arg158+Arg	N	NT	Asn	Lys	Pro	Arg	Arg	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-160	Peptide-Arg159+Pro	N	NT	Lys	Pro	Arg	Arg	Pro	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-161	Peptide-Pro160+Tyr	N	NT	Pro	Arg	Arg	Pro	Tyr	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-162	Peptide-Tyr161+Ile	N	NT	Arg	Arg	Pro	Tyr	Ile	-	-	-	Umetsu et al., 1998
Neurotensin	P30990	151-163	Peptide-Ile162+Leu	N	NT	Arg	Pro	Tyr	Ile	Leu	-	-	-	Umetsu et al., 1998
[desGly1] cholecystokinin-5	P06307	100-103	Trp-Met-Asp102+Phe-NH2	N	NT	-	Trp	Met	Asp	Phe	NH2	-	-	Umetsu et al., 1998