Substrates for peptidase S01.160: kallikrein 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Antileukoproteinase	P03973	26-132	peptide-Arg45+Tyr-peptide	P	NT	Gln	Cys	Leu	Arg	Tyr	Lys	Lys	Pro	Borgoño et al., 2007
Bz-Arg-NHPhNO2 (BAPNA)			Bz-Arg+NHPhNO2	S		-	-	Bz	Arg	NAN	-	-	-	Hauske et al., 2009
Bz-Pro-Phe-Arg-NHPhNO2			Bz-Pro-Phe-Arg+NHPhNO2	S		Bz	Pro	Phe	Arg	NAN	-	-	-	Chao, 2004
coagulation factor XII	P00748	20-615	peptide-Arg362+Leu-peptide	P		Cys	Gly	Gln	Arg	Leu	Arg	Lys	Ser	Cool et al., 1985	18072
Desmoglein-1	Q02413	50-1049	peptide-Lys197+Ile-peptide	P	NT	Ile	Ala	Phe	Lys	Ile	Ile	Arg	Gln	Borgoño et al., 2007
Desmoglein-1	Q02413	50-1049	peptide-Lys445+Asn-peptide	P	NT	Leu	Thr	Leu	Lys	Asn	Lys	Val	Thr	Borgoño et al., 2007
DL-Val-Leu-Arg-NHPhNO2			DL-Val-Leu-Arg+NHPhNO2	S		-	Val	Leu	Arg	NAN	-	-	-	Chao, 2004
Kallikrein-9 precursor	Q9UKQ9	16-250	peptide-Arg22+Ala-peptide	P	NT	Ala	Asp	Thr	Arg	Ala	Ile	Gly	Ala	Yoon et al., 2007
kininogen-1	P01042	19-644	peptide-Met361+Lys-peptide	P		Ile	Ser	Leu	Met	Lys	Arg	Pro	Pro	Del Nery et al., 1996	17292
kininogen-1	P01042	19-644	peptide-Arg371+Ser-peptide	P		Ser	Pro	Phe	Arg	Ser	Ser	Arg	Ile	Gomes et al., 1997	17291
phage display octapeptide 3R-1			peptide-Arg4+Ser-peptide	N		Leu	Glu	Ala	Arg	Ser	Ala	Tyr	His	Li et al., 2008
phage display octapeptide 3R-13			peptide-Arg4+Ser-peptide	N		Glu	Ala	Lys	Arg	Ser	Tyr	His	Ser	Li et al., 2008
phage display octapeptide 3R-7			peptide-Trp4+Ser-peptide	N		Pro	Asn	Arg	Trp	Ser	Thr	Gly	Ala	Li et al., 2008
phage display octapeptide 4R-25			peptide-Tyr4+Ser-peptide	N		Glu	Ala	Phe	Tyr	Ser	Gln	Arg	Phe	Li et al., 2008
phage display octapeptide 5R-18			peptide-Ile4+Ser-peptide	N		Ser	Ser	Tyr	Ile	Ser	Asn	Phe	Gly	Li et al., 2008
phage display octapeptide 5R-4			peptide-Arg4+Ser-peptide	N		Asn	Ala	Ala	Arg	Ser	Thr	Gly	Ala	Li et al., 2008
phage display octapeptide 6R-11			peptide-Trp4+Ser-peptide	N		Ser	Ser	Glu	Trp	Ser	Met	Pro	Tyr	Li et al., 2008
phage display octapeptide 6R-13			peptide-Phe4+Arg-peptide	N		Gly	Thr	Leu	Phe	Arg	Ser	Gly	Asn	Li et al., 2008
phage display octapeptide 6R-26			peptide-Tyr4+Ser-peptide	N		Ala	Arg	Leu	Tyr	Ser	Arg	Gly	Ala	Li et al., 2008
phage display octapeptide 6R-27			peptide-Arg4+Ser-peptide	N		Glu	Ala	Ser	Arg	Ser	Ala	Thr	Leu	Li et al., 2008
phage display octapeptide 6R-28			peptide-Tyr4+Arg-peptide	N		Glu	Ala	Ser	Tyr	Arg	Arg	Lys	Gln	Li et al., 2008
phage display octapeptide 6R-29			peptide-Tyr4+Arg-peptide	N		Thr	Thr	Phe	Tyr	Arg	Arg	Gly	Ala	Li et al., 2008
phage display octapeptide 6R-30			peptide-Tyr4+Arg-peptide	N		Ala	Ala	Trp	Tyr	Arg	Thr	Ser	Arg	Li et al., 2008
phage display octapeptide 6R-44			peptide-Tyr4+Arg-peptide	N		Ser	Phe	His	Tyr	Arg	Met	Val	Gly	Li et al., 2008
phage display octapeptide 6R-5			peptide-Tyr4+Arg-peptide	N		Ala	Ser	Ser	Tyr	Arg	Thr	Ser	Arg	Li et al., 2008
phage display octapeptide 6R-8			peptide-Tyr4+Ser-peptide	N		Thr	Arg	Phe	Tyr	Ser	Arg	Gly	Arg	Li et al., 2008
Pro-Phe-Arg-NHMec			Pro-Phe-Arg+NHMec	S		-	Pro	Phe	Arg	AMC	-	-	-	Chao, 2004
Proteinase-activated receptor 1	P25116	38-60	Peptide-Arg41+Ser-Peptide	N	NT	Leu	Asp	Pro	Arg	Ser	Phe	Leu	Leu	Parry et al., 1996
SERPINA4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	P29622	1-427	peptide-Phe388+Ser-peptide	P		Ile	Lys	Phe	Phe	Ser	Ala	Gln	Thr	Chai et al., 1993	24037
Tos-Arg-OMe (TAME)			Tos-Arg+OMe	S		-	-	Tos	Arg	OMe	-	-	-	Chao, 2004
Val-Leu-Arg-NHMec			Val-Leu-Arg+NHMec	S		-	Val	Leu	Arg	AMC	-	-	-	Chao, 2004