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Peptidase

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Substrates for peptidase C25.002: gingipain K

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
adrenocorticotrophin (11-24) P01189 148-161 Lys-Pro-Val-Gly-Lys+Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro N Pro Val Gly Lys Lys Arg Arg Pro Pike et al., 1994
adrenocorticotrophin (11-24) P01189 148-161 Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys+Val-Tyr-Pro N Arg Pro Val Lys Val Tyr Pro - Pike et al., 1994
arginine-specific cysteine proteinase RgpA B2RM93 1-1703 peptide-Lys686+Thr-peptide P CS Pro Ser Thr Lys Thr Asn Ala Thr Veith et al., 2004
arginine-specific cysteine proteinase RgpA B2RM93 1-1703 peptide-Lys1402+Lys-peptide P CS Pro Ser Ala Lys Lys Thr Glu Gly Veith et al., 2004
arginine-specific cysteine proteinase RgpA B2RM93 1-1703 peptide-Lys1079+Gly-peptide P CS Ile Thr Ala Lys Gly Val Arg Ser Veith et al., 2004
arginine-specific cysteine proteinase RgpA B2RM93 1-1703 peptide-Lys1255+Gly-peptide P CS Gly Ile Asn Lys Gly Gly Ala Arg Veith et al., 2004
beta-endorphin P01189 237-267 peptide-Lys18+Asn-peptide N Thr Leu Phe Lys Asn Ala Ile Ile Pike et al., 1994 16288
beta-endorphin P01189 237-267 peptide-Lys23+Asn-peptide N Ala Ile Ile Lys Asn Ala Tyr Lys Pike et al., 1994 16289
beta-endorphin P01189 237-267 peptide-Lys27+Lys-peptide N Asn Ala Tyr Lys Lys Gly Glu - Pike et al., 1994 16290
beta-endorphin P01189 237-267 peptide-Lys8+Ser-peptide N Thr Ser Glu Lys Ser Gln Thr Pro Pike et al., 1994 16291
C5a anaphylatoxin chemotactic receptor P21730 9-29 Peptide-Lys17+Asp-Peptide N NT Tyr Asp Asp Lys Asp Thr Leu Asp Jagels et al., 1996
C5a anaphylatoxin chemotactic receptor P21730 9-29 Peptide-Lys28+Thr N NT Pro Val Asp Lys Thr - - - Jagels et al., 1996
consensus lysyl bond peptide-Lys+peptide N - - NPe Lys CPe - - - Pike et al., 2004
D-Val-Leu-Lys-NHPhNO2 D-Val-Leu-Lys+NHPhNO2 S - DVa Leu Lys NAN - - - Pike et al., 1994
D-Val-Phe-Lys-NHPhNO2 D-Val-Phe-Lys+NHPhNO2 S - DVa Phe Lys NAN - - - Pike et al., 1994
hagA protein P59915 26-2164 peptide-Lys1212+Pro-peptide P Asn Gly Ala Lys Pro Gln Ser Val Imamura et al., 2004 16293
hagA protein P59915 26-2164 peptide-Arg684+Ala-peptide P Asn Gly Lys Arg Ala Asp Phe Thr Imamura et al., 2004 16292
interleukin-6 P05231 30-212 peptide-Lys199+Glu-peptide P Arg Ser Phe Lys Glu Phe Leu Gln Banbula et al., 1999 18861
interleukin-8 P10145 23-99 peptide-Lys30+Glu-peptide P Arg Ser Ala Lys Glu Leu Arg Cys Dias et al., 2007 20568
interleukin-8 P10145 23-99 peptide-Lys38+Thr-peptide P Gln Cys Ile Lys Thr Tyr Ser Lys Dias et al., 2007 20571
interleukin-8 P10145 23-99 peptide-Lys42+Pro-peptide P Thr Tyr Ser Lys Pro Phe His Pro Dias et al., 2007 20572
lys-gingipain Q6Q4T4 1-1358 peptide-Lys928+Gly-peptide P CS Gly Ile Asn Lys Gly Gly Ala Arg Veith et al., 2004
lys-gingipain Q6Q4T4 1-1358 peptide-Lys1077+Arg-peptide P CS Pro Ala Ser Lys Arg Ala Glu Val Veith et al., 2004
lys-gingipain P72194 1-1723 peptide-Lys1422+Arg-peptide P CS Pro Ser Gly Lys Arg Gly Glu Leu Veith et al., 2004
lys-gingipain P72194 1-1723 peptide-Lys1099+Gly-peptide P CS Ile Thr Ala Lys Gly Val Arg Ser Veith et al., 2004
lys-gingipain P72194 1-1723 peptide-Lys1275+Gly-peptide P CS Gly Ile Asn Lys Gly Gly Ala Arg Veith et al., 2004
lys-gingipain W83 Q51817 25-1732 Lys+Ile-peptide P NT - - - Lys Ile Lys Leu Asp Huq et al., 2013
lys-gingipain W83 Q51817 25-1732 peptide-Lys60+Gly-peptide P NT Val Glu Thr Lys Gly Gly Thr Phe Huq et al., 2013
lys-gingipain W83 Q51817 25-1732 peptide-Lys88+Leu-peptide P NT Ala Val Arg Lys Leu Ile Ala Val Huq et al., 2013
lys-gingipain W83 Q51817 25-1732 peptide-Lys119+Leu-peptide P NT Gly Ser Glu Lys Leu Met Pro His Huq et al., 2013
lys-gingipain W83 Q51817 25-1732 peptide-Lys129+Ser-peptide P NT Ser Met Ser Lys Ser Asp Asp Pro Huq et al., 2013
lys-gingipain W83 Q51817 25-1732 peptide-Lys148+Gly-peptide P NT Tyr Ala Arg Lys Gly Phe Val Gly Huq et al., 2013
lys-gingipain W83 Q51817 25-1732 peptide-Lys187+Val-peptide P NT Asn Gln Leu Lys Val Arg Asn Asn Huq et al., 2013
lys-gingipain W83 Q51817 25-1732 peptide-Lys223+Gln-peptide P NT Thr Ala Tyr Lys Gln Leu Phe Asn Huq et al., 2013
Lys-Pro bond peptide-Lys+Pro-peptide N - - NPe Lys Pro CPe - - Pike et al., 2004
melittin P01501 44-69 Gly-Ile-Gly-Ala-Val-Leu-Lys+Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 N Ala Val Leu Lys Val Leu Thr Thr Pike et al., 1994 16294
mellitin P01501 44-69 Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys+Arg-Lys-Arg-Gln-Gln-NH2 N Ser Trp Ile Lys Arg Lys Arg Gln Pike et al., 1994
neurotensin P30990 151-163 Glp-Leu-Tyr-Glu-Asn-Lys+Pro-Arg-Arg-Pro-Tyr-Ile-Leu N Tyr Glu Asn Lys Pro Arg Arg Pro Pike et al., 1994 16296
synthetic peptide 1 Glu-Glu-Ile-Ser-Glu-Val-Lys+Met-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-lu-Val-His-His-Gln-Lys-Leu-Val-Phe N Ser Glu Val Lys Met Asp Ala Glu Pike et al., 1994
synthetic peptide 1 Glu-Glu-Ile-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-lu-Val-His-His-Gln-Lys+Leu-Val-Phe N His His Gln Lys Leu Val Phe - Pike et al., 1994
synthetic peptide 2 Glu-Glu-Ile-Ser-Glu-Val-Asp-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-lu-Val-His-His-Gln-Lys+Leu-Val-Phe N His His Gln Lys Leu Val Phe - Pike et al., 1994
Tos-Gly-Pro-Lys-NHPhNO2 Tos-Gly-Pro-Lys+NHPhNO2 S Tos Gly Pro Lys NAN - - - Pike et al., 2004
tumor necrosis factor P01375 77-233 peptide-Lys141+Gly-peptide P Val Leu Phe Lys Gly Gln Gly Cys Calkins et al., 1998 20528
tumor necrosis factor P01375 77-233 peptide-Lys166+Val-peptide P Tyr Gln Thr Lys Val Asn Leu Leu Calkins et al., 1998 20529
tumor necrosis factor P01375 77-233 peptide-Lys174+Ser-peptide P Ser Ala Ile Lys Ser Pro Cys Gln Calkins et al., 1998 20530
Z-Lys-NHPhNO2 Z-Lys+NHPhNO2 S - - Z Lys NAN - - - Pike et al., 2004
[Met-Lys]-bradykinin P01042 379-389 Met-Lys+Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg N - - Met Lys Arg Pro Pro Gly Pike et al., 1994

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