Substrates for peptidase M02.004: angiotensin-converting enzyme peptidase unit 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Ser-Asp-Lys-Pro			Ac-Ser-Asp+Lys-Pro	S	-	Ac	Ser	Asp	Lys	Pro	-	-	Corvol et al., 2004
acetyl amyloid-beta peptide 1-16 amide	P08592	671-687	Met-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg+His-Gln-Lys	N	Phe	Glu	Val	Arg	His	Gln	Lys	'-'	Kugaevskaya et al., 2018
acetyl amyloid-beta peptide 1-16 amide	P08592	671-687	Met-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His+Gln-Lys	N	Glu	Val	Arg	His	Gln	Lys	'-'	'-'	Kugaevskaya et al., 2018
acetyl amyloid-beta peptide 1-16 amide	P08592	671-687	Met-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln+Lys	N	Val	Arg	His	Gln	Lys	'-'	'-'	'-'	Kugaevskaya et al., 2018
amyloid-beta peptide 1-16	P05067	672-687	Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His+His-Gln-Lys	N	Tyr	Glu	Val	His	His	Gln	Lys	'-'	Kugaevskaya et al., 2018
amyloid-beta peptide 1-16	P05067	672-687	Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His+Gln-Lys	N	Glu	Val	His	His	Gln	Lys	'-'	'-'	Kugaevskaya et al., 2018
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg	N	Gly	Phe	Ser	Pro	Phe	Arg	-	-	Corvol et al., 2004	16425
Bz-Gly-His-Leu			Bz-Gly+His-Leu	S	-	-	Bz	Gly	His	Leu	-	-	Corvol et al., 2004
gonadoliberin-1	P01148	24-33	Glp-His-Trp+Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2	N	-	Glp	His	Trp	Ser	Tyr	Gly	Leu	Corvol et al., 2004
myelin basic protein	P02687	1-169	peptide-Phe42+Phe-peptide	N	Leu	Gly	Arg	Phe	Phe	Gly	Ser	Asp	Amour et al., 1999
myelin basic protein	P02687	1-169	peptide-Phe88+Phe-peptide	N	Val	Val	His	Phe	Phe	Lys	Asn	Ile	Amour et al., 1999
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe+Gly-Leu-Met-NH2	N	Gln	Gln	Phe	Phe	Gly	Leu	Met	NH2	Corvol et al., 2004
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly+Leu-Met-NH2	N	Gln	Phe	Phe	Gly	Leu	Met	NH2	-	Corvol et al., 2004