Substrates for peptidase M16.017: plinsulysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Abz-Ser-Lys-Arg-Asp-Pro-Pro-Lys-Met-Gln-Thr-Asp-Lys-Tyr(NO3)-NH2			Abz-Ser-Lys-Arg-Asp-Pro-Pro-Lys+Met-Gln-Thr-Asp-Lys-Tyr(NO3)-NH2	S		Asp	Pro	Pro	Lys	Met	Gln	Thr	Asp	Huet et al., 2008
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly+Phe-Ser-Pro-Phe-Arg	N		Arg	Pro	Pro	Gly	Phe	Ser	Pro	Phe	Huet et al., 2008
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg	N		Gly	Phe	Ser	Pro	Phe	Arg	-	-	Huet et al., 2008
glucagon	P01272	53-81	peptide-Trp77+Leu-peptide	N		Phe	Val	Gln	Trp	Leu	Met	Asn	Thr	Huet et al., 2008
glucagon	P01272	53-81	peptide-Arg69+Arg-peptide	N		Leu	Asp	Ser	Arg	Arg	Ala	Gln	Asp	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Cya	Gly	Ser	His	Leu	Val	Glu	Ala	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		His	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Val	Glu	Ala	Leu	Tyr	Leu	Val	Cya	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala	N		Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Huet et al., 2008
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro+Lys-Ala	N		Phe	Tyr	Thr	Pro	Lys	Ala	-	-	Huet et al., 2008
melittin	P01501	44-69	peptide-Ala58+Leu-peptide	N		Gly	Leu	Pro	Ala	Leu	Ile	Ser	Trp	Huet et al., 2008
melittin	P01501	44-69	peptide-Lys66+Arg-Gln-Gln	N		Ile	Lys	Arg	Lys	Arg	Gln	Gln	-	Huet et al., 2008
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln+Gln-Phe-Phe-Gly-Leu-Met	N		Pro	Lys	Pro	Gln	Gln	Phe	Phe	Gly	Huet et al., 2008
systemin	P27058	179-196	Ala-Val-Gln-Ser-Lys-Pro-Pro-Ser-Lys-Arg-Asp-Pro-Pro-Lys+Met-Gln-Thr-Asp	P	MS	Asp	Pro	Pro	Lys	Met	Gln	Thr	Asp	Huet et al., 2008