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Substrates for peptidase C01.040: cathepsin H

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Arg-NHMec Arg+NHMec S - - - Arg AMC - - - Kirschke, 2004
BH3-interacting domain death agonist (BID) P70444 1-195 peptide-Arg71+Ile-peptide P Asn Gln Gly Arg Ile Glu Pro Asp Cirman et al., 2004 19234
BH3-interacting domain death agonist (BID) P70444 1-195 peptide-Gly12+Ala-peptide P Ser Gly Leu Gly Ala Glu His Ile Cirman et al., 2004 19242
BH3-interacting domain death agonist (BID) P70444 1-195 peptide-Tyr47+Trp-peptide P Val Gln Ala Tyr Trp Glu Ala Asp Cirman et al., 2004 19243
BH3-interacting domain death agonist (BID) P70444 1-195 peptide-Ser6+Asn-peptide P Ser Glu Val Ser Asn Gly Ser Gly Cirman et al., 2004 19241
Bradykinin P01042 381-389 Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg N - Pro Pro Gly Phe Ser Pro Phe Arg Brguljan et al., 2003
Bz-Arg-NHMec Bz-Arg+NHMec S - - Bz Arg AMC - - - Kirschke, 2004
Bz-Arg-NHNap Bz-Arg+NHNap S - - Bz Arg NAP - - - Kirschke, 2004
Bz-Phe-Val-Arg-NHMec Bz-Phe-Val-Arg+NHMec S Bz Phe Val Arg AMC - - - Kirschke, 2004
Dermorphin-1 P05422 80-86 Tyr-Ala-Phe-Gly83+Tyr-Pro-Ser P - Tyr Ala Phe Gly Tyr Pro Ser - Brguljan et al., 2003
Dynorphin A 1-13 P01213 207-219 peptide-Leu211+Arg-peptide P - Gly Gly Phe Leu Arg Arg Ile Arg Brguljan et al., 2003
Lys-NHMec Lys+NHMec S - - - Lys AMC - - - Kirschke, 2004
Lysyl-bradykinin P01042 380-389 Lys-Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg N - Pro Pro Gly Phe Ser Pro Phe Arg Brguljan et al., 2003
osteocalcin P02818 52-100 peptide-Gly58+Ala-peptide P Gln Trp Leu Gly Ala Pro Val Pro Baumgrass et al., 1997 3108
Pro-Arg+NHNap Pro-Arg+NHNap S - - Pro Arg NAP - - - Kirschke, 2004
Pro-Gly-Phe Pro-Gly+Phe N - - Pro Gly Phe - - - Kirschke, 2004
pulmonary surfactant-associated protein B P07988 25-381 peptide-Ala187+Arg-peptide P Ala Leu Gln Ala Arg Pro Gly Pro Ueno et al., 2004 19496
pulmonary surfactant-associated protein B P07988 25-381 peptide-Met279+Asp-peptide P Arg Cys Ser Met Asp Asp Ser Ala Ueno et al., 2004 19497
pulmonary surfactant-associated protein B P07988 25-381 peptide-Ala316+Ile-peptide P Ser Glu Gln Ala Ile Pro Gln Ala Ueno et al., 2004 19498
pulmonary surfactant-associated protein B P07988 25-381 peptide-Leu349+Val-peptide P Leu Leu Thr Leu Val Pro Arg Gly Ueno et al., 2004 19499
pulmonary surfactant-associated protein B P07988 25-381 peptide-His377+Ser-peptide P Gln Cys Ile His Ser Pro Asp Leu Ueno et al., 2004 19500
talin-1 Q9Y490 2-23 Val+Ala-peptide P MS - - - Val Ala Leu Ser Leu Jevnikar et al., 2013
talin-1 Q9Y490 2-23 peptide-Leu6+Lys-peptide P MS Ala Leu Ser Leu Lys Ile Ser Ile Jevnikar et al., 2013
talin-1 Q9Y490 7-23 Lys7+Ile-peptide P MS - - - Lys Ile Ser Ile Gly Jevnikar et al., 2013
talin-1 Q9Y490 8-23 Ile8+Ser-peptide P MS - - - Ile Ser Ile Gly Asn Jevnikar et al., 2013
talin-1 Q9Y490 2-23 peptide-Ser22+Thr P MS Phe Glu Pro Ser Thr - - - Jevnikar et al., 2013
talin-1 Q9Y490 9-23 Ser9+Ile-peptide P MS - - - Ser Ile Gly Asn Val Jevnikar et al., 2013
talin-1 Q9Y490 10-23 Ile+Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe-Glu-Pro-Ser-Thr P MS - - - Ile Gly Asn Val Val Jevnikar et al., 2013
talin-1 Q9Y490 11-23 Gly+Asn-Val-Val-Lys-Thr-Met-Gln-Phe-Glu-Pro-Ser-Thr P MS - - - Gly Asn Val Val Lys Jevnikar et al., 2013
talin-1 Q9Y490 12-23 Asn+Val-Val-Lys-Thr-Met-Gln-Phe-Glu-Pro-Ser-Thr P MS - - - Asn Val Val Lys Thr Jevnikar et al., 2013
talin-1 Q9Y490 11-23 Gly-Asn-Val-Val+Lys-Thr-Met-Gln-Phe-Glu-Pro-Ser-Thr P MS Gly Asn Val Val Lys Thr Met Gln Jevnikar et al., 2013
talin-1 Q9Y490 7-23 Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met+Gln-Phe-Glu-Pro-Ser-Thr P MS Val Lys Thr Met Gln Phe Glu Pro Jevnikar et al., 2013
talin-1 Q9Y490 7-23 Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe-Glu-Pro-Ser+Thr P MS Phe Glu Pro Ser Thr - - - Jevnikar et al., 2013
talin-1 Q9Y490 3-23 Ala-Leu-Ser-Leu-Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe-Glu+Ser-peptide P MS Gln Phe Glu Pro Ser Thr - - Jevnikar et al., 2013
talin-1 Q9Y490 3-21 Ala-Leu-Ser-Leu-Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys+Thr-Met-Gln-Phe-Glu-Pro P MS Asn Val Val Lys Thr Met Gln Phe Jevnikar et al., 2013
talin-1 Q9Y490 10-23 Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe-Glu-Pro+Ser-Thr P MS Gln Phe Glu Pro Ser Thr - - Jevnikar et al., 2013
talin-1 Q9Y490 15-23 Lys-Thr-Met-Gln-Phe-Glu+Pro-Ser-Thr P MS Met Gln Phe Glu Pro Ser Thr - Jevnikar et al., 2013
talin-1 Q9Y490 10-21 Ile-Gly-Asn-Val-Val+Lys-Thr-Met-Gln-Phe-Glu-Pro P MS Gly Asn Val Val Lys Thr Met Gln Jevnikar et al., 2013
talin-1 Q9Y490 9-23 Ser-Ile-Gly-Asn-Val-Val-Lys-Thr+Met-Gln-Phe-Glu-Pro-Ser-Thr P MS Val Val Lys Thr Met Gln Phe Glu Jevnikar et al., 2013
talin-1 Q9Y490 8-23 Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe-Glu-Pro+Ser-Thr P MS Gln Phe Glu Pro Ser Thr - - Jevnikar et al., 2013
talin-1 Q9Y490 8-21 Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln+Phe-Glu-Pro P MS Lys Thr Met Gln Phe Glu Pro - Jevnikar et al., 2013
talin-1 Q9Y490 3-21 Ala+Leu-Ser-Leu-Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe-Glu-Pro P MS - - - Ala Leu Ser Leu Lys Jevnikar et al., 2013
talin-1 Q9Y490 3-21 Ala-Leu-Ser-Leu-Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe+Glu-Pro P MS Thr Met Gln Phe Glu Pro - - Jevnikar et al., 2013
talin-1 Q9Y490 4-19 Leu-Ser-Leu-Lys-Ile-Ser-Ile+Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe P MS Lys Ile Ser Ile Gly Asn Val Val Jevnikar et al., 2013
talin-1 Q9Y490 4-10 Leu+Ser-Leu-Lys-Ile-Ser-Ile P MS - - - Leu Ser Leu Lys Ile Jevnikar et al., 2013
talin-1 Q9Y490 4-10 Leu-Ser-Leu-Lys-Ile-Ser+Ile P MS Leu Lys Ile Ser Ile - - - Jevnikar et al., 2013
talin-1 Q9Y490 4-19 Leu-Ser+Leu-Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys-Thr-Met-Gln-Phe P MS - - Leu Ser Leu Lys Ile Ser Jevnikar et al., 2013
talin-1 Q9Y490 4-19 Leu-Ser-Leu-Lys-Ile-Ser-Ile-Gly-Asn-Val-Val-Lys+Thr-Met-Gln-Phe P MS Asn Val Val Lys Thr Met Gln Phe Jevnikar et al., 2013

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