Substrates for peptidase M01.024: ERAP2 aminopeptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ala-Val-Pro-Tyr-Gly-Ser-Phe-Lys-His-Val			Ala+Val-Pro-Tyr-Gly-Ser-Phe-Lys-His-Val	P		-	-	-	Ala	Val	Pro	Tyr	Gly	Tanioka et al., 2003
angiotensin-3	P01019	35-41	Arg+Val-Tyr-Ile-His-Pro-Phe	N		-	-	-	Arg	Val	Tyr	Ile	His	Tanioka et al., 2003
Arg-NHMec			Arg+NHMec	S		-	-	-	Arg	AMC	-	-	-	Tanioka et al., 2003
Asn-Tyr-Thr-Pro-Gly-Pro-Gly-Val-Arg-Tyr			Asn+Tyr-Thr-Pro-Gly-Pro-Gly-Val-Arg-Tyr	P		-	-	-	Asn	Tyr	Thr	Pro	Gly	Tanioka et al., 2003
envelope glycoprotein gp160	P04624	306-320	Lys+Ile-Arg-Ile-Gln-Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile	P	NT	-	-	-	Lys	Ile	Arg	Ile	Gln	Saveanu et al., 2005
envelope glycoprotein gp160	P04624	308-320	Arg+Ile-Gln-Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile	P	NT	-	-	-	Arg	Ile	Gln	Arg	Gly	Saveanu et al., 2005
envelope glycoprotein gp160	P04624	310-320	Gln+Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile	P	NT	-	-	-	Gln	Arg	Gly	Pro	Gly	Saveanu et al., 2005
envelope glycoprotein gp160	P04624	311-320	Arg+Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile	P	NT	-	-	-	Arg	Gly	Pro	Gly	Arg	Saveanu et al., 2005
Leu-NHMec			Leu+NHMec	S		-	-	-	Leu	AMC	-	-	-	Saveanu et al., 2005
Lys-NHMec			Lys+NHMec	S		-	-	-	Lys	AMC	-	-	-	Saveanu et al., 2005
Lysyl-bradykinin			Lys+Arg-Pro-Pro-Gly+Phe-Ser-Pro-Phe-Arg	N		-	-	-	Lys	Arg	Pro	Pro	Gly	Tanioka et al., 2003
Lysyl-bradykinin	P01042	380-389	Lys380+Arg-peptide	N	MS	-	-	-	Lys	Arg	Pro	Pro	Gly	Tanioka et al., 2003
Melanocyte protein PMEL	P40967	207-217	Phe207+Thr-peptide	N	MS	-	-	-	Phe	Thr	Ile	Thr	Asp	Tanioka et al., 2003
Melanocyte protein PMEL	P40967	208-217	Thr208+Ile-peptide	N	MS	-	-	-	Thr	Ile	Thr	Asp	Gln	Tanioka et al., 2003
Melanocyte protein PMEL	P40967	209-217	Ile209+Thr-peptide	N	MS	-	-	-	Ile	Thr	Asp	Gln	Val	Tanioka et al., 2003
Melanocyte protein PMEL	P40967	210-217	Thr210+Asp-peptide	N	MS	-	-	-	Thr	Asp	Gln	Val	Pro	Tanioka et al., 2003
Melanocyte protein PMEL	P40967	211-217	Asp211+Gln-peptide	N	MS	-	-	-	Asp	Gln	Val	Pro	Phe	Tanioka et al., 2003
Nef protein	P04601	126-135	Asn126+Tyr-peptide	N	MS	-	-	-	Asn	Tyr	Thr	Pro	Gly	Tanioka et al., 2003
Nef protein	P04601	127-135	Tyr127+Thr-peptide	N	MS	-	-	-	Tyr	Thr	Pro	Gly	Pro	Tanioka et al., 2003
Phe-NHMec			Phe+NHMec	S		-	-	-	Phe	AMC	-	-	-	Saveanu et al., 2005
Scm-like with four MBT domains protein 1	Q9UHJ3	32-42	Thr32+Ala-peptide	N	MS	-	-	-	Thr	Ala	Val	Pro	Tyr	Tanioka et al., 2003
Scm-like with four MBT domains protein 1	Q9UHJ3	33-42	Ala33+Val-peptide	N	MS	-	-	-	Ala	Val	Pro	Tyr	Gly	Tanioka et al., 2003
Thr-Ala-Val-Pro-Tyr-Gly-Ser-Phe-Lys-His-Val			Thr+Ala-Val-Pro-Tyr-Gly-Ser-Phe-Lys-His-Val	P		-	-	-	Thr	Ala	Val	Pro	Tyr	Tanioka et al., 2003
Tyr-Thr-Pro-Gly-Pro-Gly-Val-Arg-Tyr			Tyr+Thr-Pro-Gly-Pro-Gly-Val-Arg-Tyr	P		-	-	-	Tyr	Thr	Pro	Gly	Pro	Tanioka et al., 2003
[desArg1 Val2 Tyr3] angiotensin-3	P01019	38-41	Ile38+His-Pro-Phe	N	MS	-	-	-	Ile	His	Pro	Phe	-	Tanioka et al., 2003
[desArg1 Val2] angiotensin-3	P01019	37-41	Tyr37+Ile-His-Pro-Phe	N	MS	-	-	-	Tyr	Ile	His	Pro	Phe	Tanioka et al., 2003
[desArg1] angiotensin-3	P01019	36-41	Val36+Tyr-Peptide	N	MS	-	-	-	Val	Tyr	Ile	His	Pro	Tanioka et al., 2003