Substrates for peptidase M9G.026: dactylysin

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Amyloid beta A4 protein	P05067	683-692	Peptide-Leu688+Val-Phe-Phe-Ala	N	MS	His	Gln	Lys	Leu	Val	Phe	Phe	Ala	Clamagirand et al., 2002
Amyloid beta A4 protein	P05067	683-692	Peptide-Phe690+Phe-Ala	N	MS	Lys	Leu	Val	Phe	Phe	Ala	-	-	Clamagirand et al., 2002
angiotensin-2	P01019	34-41	Asp-Arg-Val-Tyr+Ile-His-Pro-Phe	N		Ala	Arg	Val	Tyr	Ile	His	Pro	Phe	Clamagirand et al., 2004
atrial natriuretic factor 21-28	P01160	134-143	Leu-Gly-Cys-Asn-Ser+Phe-Arg-Tyr	N		Gly	Cys	Asn	Ser	Phe	Arg	Tyr	-	Clamagirand et al., 2004
Beta-amyloid protein 40	P05067	672-711	Peptide-His685+Gln-Peptide	N	MS	Glu	Val	His	His	Gln	Lys	Leu	Val	Clamagirand et al., 2002
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly+Phe-Ser-Pro-Phe-Arg	N		Arg	Pro	Pro	Gly	Phe	Ser	Pro	Phe	Clamagirand et al., 2004	16520
Bradykinin	P01042	381-389	Peptide-Pro387+Phe-Arg	N	NT	Gly	Phe	Ser	Pro	Phe	Arg	-	-	Carvalho et al., 1992
dynorphin A1-16	P01214	209-224	Tyr-Gly-Gly-Phe+Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn	N		Tyr	Gly	Gly	Phe	Leu	Arg	Arg	Ile	Clamagirand et al., 2004
Kermit			Asp-Val-Asp-Glu-Arg-Asp-Val-Arg-Gly-Phe-Ala-Ser+Phe-Leu-NH2	N		Gly	Phe	Ala	Ser	Phe	Leu	-	-	Clamagirand et al., 2004
Leu-enkephalin	P01213	207-211	Tyr-Gly-Gly209+Phe-Leu-NH2	N	MS	-	Tyr	Gly	Gly	Phe	Leu	NH2	-	Clamagirand et al., 2002
Litorin	P08945	1-9	Peptide-Gly6+His-Phe-Met-NH2	N	NT	Trp	Ala	Val	Gly	His	Phe	Met	NH2	Carvalho et al., 1992
Litorin	P08945	1-9	Peptide-His7+Phe-Met-NH2	N	NT	Ala	Val	Gly	His	Phe	Met	NH2	-	Carvalho et al., 1992
neurokinin A			His-Lys-Thr-Asp-Ser-Phe-Val-Gly+Leu-Met-NH2	N		Ser	Phe	Val	Gly	Leu	Met	-	-	Clamagirand et al., 2004
neuromedin-B	P08949	47-56	Peptide-Gly53+His-Phe-Met-NH2	N	NT	Trp	Ala	Thr	Gly	His	Phe	Met	NH2	Carvalho et al., 1992
neuromedin-B	P08949	47-56	Peptide-His54+Phe-Met-NH2	N	NT	Ala	Thr	Gly	His	Phe	Met	NH2	-	Carvalho et al., 1992
Neuromedin-C	P07492-1	41-50	Peptide-Gly47+His-Leu-Met-NH2	N	NT	Trp	Ala	Val	Gly	His	Leu	Met	NH2	Carvalho et al., 1992
Neuromedin-C	P07492-1	41-50	Peptide-His48+Leu-Met-NH2	N	NT	Ala	Val	Gly	His	Leu	Met	NH2	-	Carvalho et al., 1992
PGLa antimicrobial peptide	Q99134	36-59	peptide-Lys12+Ile-peptide	P		Ile	Ala	Gly	Lys	Ile	Ala	Lys	Val	Clamagirand et al., 2004	16523
somatostatin-14	P61278	103-116	Ala-Gly-Cys-Lys-Asn-Phe+Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys	N		Cys	Lys	Asn	Phe	Phe	Trp	Lys	Thr	Clamagirand et al., 2004	16524
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe+Phe-Gly-Leu-Met-NH2	N		Lys	Gln	Gln	Phe	Phe	Gly	Leu	Met	Clamagirand et al., 2004
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly+Leu-Met-NH2	N		Gln	Phe	Phe	Gly	Leu	Met	NH2	-	Clamagirand et al., 2004
[Arg0,Leu5,Arg6]-enkephalin	P01213	174-180	Arg-Tyr-Gly-Gly-Phe+Leu-Arg-NH2	N		Tyr	Gly	Gly	Phe	Leu	Arg	-	-	Clamagirand et al., 2004
[Leu5,Arg6]-enkephalin	P01213	175-179	Tyr-Gly-Gly-Phe+Leu-Arg-NH2	N		Tyr	Gly	Gly	Phe	Leu	Arg	-	-	Clamagirand et al., 2004