Substrates for peptidase M01.003: aminopeptidase A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
angiotensin-2	P01019	34-41	Arg34+Arg-peptide	P	NT	-	-	-	Asp	Arg	Val	Tyr	Ile	Goto et al., 2007	20186
angiotensin-3	P01019	35-41	Arg35+Val-peptide	P	NT	-	-	-	Arg	Val	Tyr	Ile	His	Goto et al., 2007
Asp-NHNAP			Asp+NHNAP	S		-	-	-	Asp	NAP	-	-	-	Arechaga et al., 1996
cholecystokinin-8	P06307	96-103	Asp+Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2	N		-	-	-	Asp	Tyr	Met	Gly	Trp	Migaud etal, 1996	4062
chromogranin-A	P10645	304-319	Glu+Glu-Glu-Glu-Glu-Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly	N		-	-	-	Glu	Glu	Glu	Glu	Glu	Goto et al., 2006
chromogranin-A	P10645	305-319	Glu+Glu-Glu-Glu-Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly	N		-	-	-	Glu	Glu	Glu	Glu	Met	Goto et al., 2006
chromogranin-A	P10645	306-319	Glu+Glu-Glu-Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly	N		-	-	-	Glu	Glu	Glu	Met	Ala	Goto et al., 2006
chromogranin-A	P10645	307-319	Glu+Glu-Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly	N		-	-	-	Glu	Glu	Met	Ala	Val	Goto et al., 2006
chromogranin-A	P10645	308-319	Glu+Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly	N		-	-	-	Glu	Met	Ala	Val	Val	Goto et al., 2006
Glu-NHNap			Glu+NHNap	S		-	-	-	Glu	NAP	-	-	-	Wang & Cooper, 2004
Glu-NHPhNO2			Glu+NHPhNO2	S		-	-	-	Glu	NAN	-	-	-	Wang & Cooper, 2004
neurokinin B	Q9UHF0	81-90	Asp81+Met-peptide	N		-	-	-	Asp	Met	His	Asp	Phe	Goto et al., 2007
[desAsp]-neurokinin B	Q9UHF0	82-90	Met82+His-peptide	N		-	-	-	Met	His	Asp	Phe	Phe	Goto et al., 2007	26787
[Lys]-bradykinin (kallidin)	P01042	380-389	Lys+Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg	N		-	-	-	Lys	Arg	Pro	Pro	Gly	Goto et al., 2007