Substrates for peptidase M02.006: angiotensin-converting enzyme-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His+Leu	P	MS	His	Pro	Phe	His	Leu	-	-	-	Vickers et al., 2002	3647
angiotensin-2	P01019	34-41	Asp-Arg-Val-Tyr-Ile-His-Pro+Phe	P	MS	Tyr	Ile	His	Pro	Phe	-	-	-	Vickers et al., 2002	3648
apelin-13	Q9ULZ1	65-77	Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro+Phe	P	MS	Gly	Pro	Met	Pro	Phe	-	-	-	Vickers et al., 2002
apelin-36	Q9ULZ1	42-77	peptide-Pro76+Phe	P	MS	Gly	Pro	Met	Pro	Phe	-	-	-	Vickers et al., 2002
beta-Casomorphin	P05814	66-72	Tyr-Pro-Phe-Val-Glu-Pro+Ile	P	MS	Phe	Val	Glu	Pro	Ile	-	-	-	Vickers et al., 2002
des-Arg bradykinin	O08677	380-387	Pro-Pro-Gly-Phe-Ser-Pro-Phe+Arg	P	MS	Phe	Ser	Pro	Phe	Arg	-	-	-	Donoghue et al., 2000
dynorphin A (1-13)	P01213	207-219	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu+Lys	P	MS	Arg	Pro	Lys	Leu	Lys	-	-	-	Vickers et al., 2002
ghrelin-28	Q9UBU3	24-51	peptide-Pro50+Arg	P		Lys	Leu	Gln	Pro	Arg	-	-	-	Vickers et al., 2002	3649
Mca-Ala-Pro-Lys(Dnp)			Mca-Ala-Pro+Lys(Dnp)	S		-	Mca	Ala	Pro	Lyd	-	-	-	Turner & Hooper, 2004
Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)			Mca-Tyr-Val-Ala-Asp-Ala-Pro+Lys(Dnp)	S		Ala	Asp	Ala	Pro	Lyd	-	-	-	Turner & Hooper, 2004
neurotensin	P30990	151-163	peptide-Ile162+Leu	P	MS	Arg	Pro	Tyr	Ile	Leu	-	-	-	Donoghue et al., 2000
neurotensin 1-8	P30990	151-158	Gln-Leu-Tyr-Glu-Asn-Lys-Pro+Arg	P	MS	Glu	Asn	Lys	Pro	Arg	-	-	-	Vickers et al., 2002
[desArg9]-bradykinin	P01042	381-388	Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe	P	MS	Gly	Phe	Ser	Pro	Phe	-	-	-	Vickers et al., 2002
[Lys-desArg9]-bradykinin	P01042	380-388	Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe	P	MS	Gly	Phe	Ser	Pro	Phe	-	-	-	Vickers et al., 2002