Substrates for peptidase M12.008: nephrosin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg	N	Pro	Pro	Gly	Phe	Ser	Pro	Phe	Arg	Hung et al., 1997
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly+Phe-Ser-Pro-Phe-Arg	N	Arg	Pro	Pro	Gly	Phe	Ser	Pro	Phe	Hung et al., 1997
bradykinin 1-7	P01042	381-387	Arg-Pro+Pro-Gly-Phe-Ser-Pro	N	-	-	Arg	Pro	Pro	Gly	Phe	Ser	Hung et al., 1997
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe+Phe-Gly-Leu-Met	N	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Met	Hung et al., 1997
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln+Phe-Phe-Gly-Leu-Met	N	Lys	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Hung et al., 1997
[des-Arg]-bradykinin	P01042	382-389	Pro-Pro+Gly-Phe-Ser-Pro-Phe-Arg	N	-	-	Pro	Pro	Gly	Phe	Ser	Pro	Hung et al., 1997