Substrates for peptidase M02.003: peptidyl-dipeptidase Ance

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His-Leu	N	Ile	His	Pro	Phe	His	Leu	-	-	Wijffels et al., 1996
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg	N	Gly	Phe	Ser	Pro	Phe	Arg	-	-	Wijffels et al., 1996
Ile-Ser-bradykinin			Ile-Ser-Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg	N	Gly	Phe	Ser	Pro	Phe	Arg	-	-	Bingham et al., 2006
Met-Lys-Arg-Ser-Arg-Gly-Pro-Ser-Pro			Met-Lys-Arg-Ser-Arg-Gly-Pro+Ser-Pro	N	Ser	Arg	Gly	Pro	Ser	Pro	-	-	Bingham et al., 2006
Met-Lys-Arg-Ser-Arg-Gly-Pro-Ser-Pro-Arg-Arg			Met-Lys-Arg-Ser-Arg-Gly-Pro-Ser-Pro+Arg-Arg	N	Gly	Pro	Ser	Pro	Arg	Arg	-	-	Bingham et al., 2006
[Thr6]bradykinin			Arg-Pro-Pro-Gly-Phe-Thr-Pro+Phe-Arg	N	Gly	Phe	Thr	Pro	Phe	Arg	-	-	Bingham et al., 2006
[Tyr8]bradykinin			Arg-Pro-Pro-Gly-Phe-Ser-Pro+Tyr-Arg	N	Gly	Phe	Ser	Pro	Tyr	Arg	-	-	Bingham et al., 2006