Substrates for peptidase M03.007: oligopeptidase F

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg	N		Pro	Pro	Gly	Phe	Ser	Pro	Phe	Arg	Pritchard, 2004	16439
Corticotropin	P01189	138-152	Ser-Tyr-Ser-Met141+Glu-Peptide	N	MS	Ser	Tyr	Ser	Met	Glu	His	Phe	Arg	Chao et al., 2006
Corticotropin	P01189	138-152	Peptide-His143+Phe-Peptide	N	MS	Ser	Met	Glu	His	Phe	Arg	Trp	Gly	Chao et al., 2006
Corticotropin	P01189	138-152	Peptide-Phe144+Arg-Peptide	N	MS	Met	Glu	His	Phe	Arg	Trp	Gly	Lys	Chao et al., 2006
Corticotropin	P01189	138-152	Peptide-Gly147+Lys-Pro-Val-Gly	N	MS	Phe	Arg	Trp	Gly	Lys	Pro	Val	Gly	Chao et al., 2006
Corticotropin	P01189	138-152	Peptide-Try146+Gly-Peptide	N	MS	His	Phe	Arg	Trp	Gly	Lys	Pro	Val	Chao et al., 2006
furylacryloyl-Leu-Gly-Pro-Ala			furylacryloyl-Leu+Gly-Pro-Ala	S		-	-	FA	Leu	Gly	Pro	Ala	-	Pritchard, 2004
hypertensin			Asn-Arg-Val-Tyr-Val+His-Pro-Phe	N		Arg	Val	Tyr	Val	His	Pro	Phe	-	Miyake et al., 2005
Insulin A chain (oxidised)	P01317	85-105	Peptide-Tyr98+Gln-Peptide	N	MS	Cya	Ser	Leu	Tyr	Gln	Leu	Glu	Asn	Chao et al., 2006
Insulin A chain (oxidised)	P01317	85-105	Peptide-Leu100+Glu-Peptide	N	MS	Leu	Tyr	Gln	Leu	Glu	Asn	Tyr	Cya	Chao et al., 2006
Insulin A chain (oxidised)	P01317	85-105	Peptide-Glu101+Asn-Peptide	N	MS	Tyr	Gln	Leu	Glu	Asn	Tyr	Cya	Asn	Chao et al., 2006
Insulin A chain (oxidised)	P01317	85-105	Peptide-Ser93+Val-Peptide	N	MS	Cya	Cya	Ala	Ser	Val	Cya	Ser	Leu	Chao et al., 2006
Insulin A chain (oxidised)	P01317	85-105	Peptide-Leu97+Tyr-Peptide	N	MS	Val	Cya	Ser	Leu	Tyr	Gln	Leu	Glu	Chao et al., 2006
Mcc-Pro-Leu-Gly-Pro-D-Lys(Dnp)			Mcc-Pro-Leu+Gly-Pro-D-Lys(Dnp)	S		-	Mcc	Pro	Leu	Gly	Pro	Lyd	-	Sugihara et al., 2007
neurotensin	P30990	151-163	Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg+Arg-Pro-Tyr-Ile-Leu	N		Asn	Lys	Pro	Arg	Arg	Pro	Tyr	Ile	Pritchard, 2004	16440
neurotensin	P30990	151-163	Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Leu	N		Pro	Arg	Arg	Pro	Tyr	Ile	Leu	-	Pritchard, 2004	16441
neurotensin	P30990	151-163	Glp-Leu-Tyr-Glu64+Asn-Peptide	N	MS	Glp	Leu	Tyr	Glu	Asn	Lys	Pro	Arg	Chao et al., 2006
Pz-Pro-Leu-Gly-Pro-Arg			Pz-Pro-Leu+Gly-Pro-Arg	N		-	Pz	Pro	Leu	Gly	Pro	Arg	-	Monnet, 2004
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe+Gly-Leu-Met	N		Gln	Gln	Phe	Phe	Gly	Leu	Met	-	Miyake et al., 2005
substance P	P20366	59-68	Peptide-Phe64+Phe-Peptide	N	MS	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Met	Chao et al., 2006
[Gly-Pro-Leu]2			Gly-Pro-Leu+Gly-Pro-Leu	S		-	Gly	Pro	Leu	Gly	Pro	Leu	-	Miyake et al., 2005
[Gly-Pro-Leu]3			Gly-Pro-Leu+Gly-Pro-Leu-Gly-Pro-Leu	S		-	Gly	Pro	Leu	Gly	Pro	Leu	Gly	Miyake et al., 2005
[Gly-Pro-Leu]3			Gly-Pro-Leu-Gly-Pro-Leu+Gly-Pro-Leu	S		Leu	Gly	Pro	Leu	Gly	Pro	Leu	-	Miyake et al., 2005
[Gly-Pro-Leu]4			Gly-Pro-Leu+Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro-Leu	S		-	Gly	Pro	Leu	Gly	Pro	Leu	Gly	Miyake et al., 2005