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Substrates for peptidase S09.001: prolyl oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Asn-Lys-Pro-Arg-Arg-Pro-Gln-EDDnp Abz-Asn-Lys-Pro-Arg-Arg-Pro+Gln-EDDnp S Pro Arg Arg Pro Gln EDD - - Oliveira et al., 2001
acyl-CoA-binding protein P11030 34-51 Gln-Ala+Thr-Val-Gly-Asp-Val-Asn-Thr-Asp-Arg-Pro-Gly-Leu-Leu-Asp-Leu-Lys N - - Gln Ala Thr Val Gly Asp Leprince et al., 2006
acyl-CoA-binding protein P11030 34-51 Gln-Ala-Thr-Val+Gly-Asp-Val-Asn-Thr-Asp-Arg-Pro-Gly-Leu-Leu-Asp-Leu-Lys N Gln Ala Thr Val Gly Asp Val Asn Leprince et al., 2006
adenylate kinase isoenzyme 1 P00571 164-183 Tyr-Glu-Lys-Arg-Gly-Ile-Val-Arg-Lys-Val-Asn-Ala+Glu-Gly-Ser-Val-Asp-Asp-Val-Phe P MS Lys Val Asn Ala Glu Gly Ser Val Brandt et al., 2005
alpha-melanocyte-stimulating hormone P01189 138-150 Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro+Val-NH2 N Trp Gly Lys Pro Val NH2 - - Ito et al., 2004
alpha-S1-casein P02662 16-214 peptide-Pro42+Phe-peptide P Phe Val Ala Pro Phe Pro Glu Val Clare & Swaisgood, 2000 24454
alpha/beta-gliadin MM1 P18573 89-101 Pro-Gln-Pro-Gln-Leu-Pro+Tyr-Pro-Gln-Pro-Gln-Leu-Pro P MS Pro Gln Leu Pro Tyr Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 89-101 Pro-Gln-Pro-Gln-Leu-Pro-Tyr-Pro+Gln-Pro-Gln-Leu-Pro P MS Leu Pro Tyr Pro Gln Pro Gln Leu Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro82+Gln-peptide P MS Gln Pro Phe Pro Gln Pro Gln Leu Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro87+Tyr-peptide P MS Pro Gln Leu Pro Tyr Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro89+Gln-peptide P MS Leu Pro Tyr Pro Gln Pro Gln Leu Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro94+Tyr-peptide P MS Pro Gln Leu Pro Tyr Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro96+Gln-peptide P MS Leu Pro Tyr Pro Gln Pro Gln Leu Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro101+Tyr-peptide P MS Pro Gln Leu Pro Tyr Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro103+Gln-peptide P MS Leu Pro Tyr Pro Gln Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro80+Phe-peptide P MS Gln Leu Gln Pro Phe Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro82+Gln-peptide P MS Gln Pro Phe Pro Gln Pro Gln Leu Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro84+Gln-peptide P MS Phe Pro Gln Pro Gln Leu Pro Tyr Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro87+Tyr-peptide P MS Pro Gln Leu Pro Tyr Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro89+Gln-peptide P MS Leu Pro Tyr Pro Gln Pro Gln Leu Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Gln92+Leu-peptide P MS Pro Gln Pro Gln Leu Pro Tyr Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro94+Tyr-peptide P MS Pro Gln Leu Pro Tyr Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro96+Gln-peptide P MS Leu Pro Tyr Pro Gln Pro Gln Leu Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro98+Gln-peptide P MS Tyr Pro Gln Pro Gln Leu Pro Tyr Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro101+Tyr-peptide P MS Pro Gln Leu Pro Tyr Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro103+Gln-peptide P MS Leu Pro Tyr Pro Gln Pro Gln Pro Shan et al., 2004
alpha/beta-gliadin MM1 P18573 76-108 peptide-Pro105+Gln-Pro-Phe P MS Tyr Pro Gln Pro Gln Pro Phe - Shan et al., 2004
aminoacyl-Ala bond peptide+Ala-peptide N - - - NPe Ala CPe - - Ito et al., 2004
aminoacyl-Ser bond peptide+Ser-peptide N - - - NPe Ser CPe - - Ito et al., 2004
angiotensin-2 P01019 34-41 Asp-Arg-Val-Tyr-Ile-His-Pro+Phe N Tyr Ile His Pro Phe - - - Koida & Walter, 1976 3723
bradykinin P01042 381-389 Arg-Pro+Pro-Gly-Phe-Ser-Pro-Phe-Arg N - - Arg Pro Pro Gly Phe Ser Ito et al., 2004 17662
bradykinin P01042 381-389 Arg-Pro-Pro+Gly-Phe-Ser-Pro-Phe-Arg N - Arg Pro Pro Gly Phe Ser Pro Koida & Walter, 1976 17663
bradykinin P01042 381-389 Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg N Gly Phe Ser Pro Phe Arg - - Koida & Walter, 1976 21614
bradykinin P01042 381-389 Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg P Gly Phe Ser Pro Phe Arg Gly Gly De Camargo et al., 1982 21626
bradykinin P01042 381-389 Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg N Gly Phe Ser Pro Phe Arg - - Mäkinen et al., 1995
bradykinin-potentiating factor Glp-Gly-Gly-Trp-Pro+Arg-Pro-Gly-Pro-Glu-Ile-Pro-Pro N Gly Gly Trp Pro Arg Pro Gly Pro Koida & Walter, 1976
bradykinin-potentiating factor Glp-Gly-Gly-Trp-Pro-Arg-Pro+Gly-Pro-Glu-Ile-Pro-Pro N Trp Pro Arg Pro Gly Pro Glu Ile Koida & Walter, 1976
bradykinin-potentiating factor Glp-Gly-Gly-Trp-Pro-Arg-Pro-Gly-Pro+Glu-Ile-Pro-Pro N Arg Pro Gly Pro Glu Ile Pro Pro Koida & Walter, 1976
dynorphin A(1-13) P01214 209-221 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro+Lys-Leu-Lys-Trp-Asp-Asn-Gln N Arg Ile Arg Pro Lys Leu Lys Trp Ito et al., 2004
gonadoliberin Gln-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro+Gly N Gly Leu Arg Pro Gly - - - Ito et al., 2004
gonadoliberin-1 P01148 24-33 peptide-Pro32+Gly-peptide P Gly Leu Arg Pro Gly Gly Gly Gly De Camargo et al., 1982 21628
gonadoliberin-1 P01148 24-33 Gln-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro+Gly P CS Gly Leu Arg Pro Gly Gly Lys Arg Lew et al., 1994
hemoglobin subunit alpha P01965 110-122 Ala-Ala-His-His-Pro-Asp-Asp-Phe-Asn-Pro+Ser-Val-His P MS Asp Phe Asn Pro Ser Val His Ala Brandt et al., 2005
hemoglobin subunit beta P02067 116-130 Ala-Arg-Arg-Leu-Gly-His-Asp-Phe-Asn-Pro+Asn-Val-Gln-Ala-Ala P MS Asp Phe Asn Pro Asn Val Gln Ala Brandt et al., 2005
luteinizing hormone-releasing hormone Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro+Gly-NH2 N Gly Leu Arg Pro Gly NH2 - - Ito et al., 2004
myelin basic protein P81558 70-89 Ser-Leu-Pro-Gln-Lys-Ala-Gln-His-Gly-Arg-Pro+Gln-Asp-Glu-Asn-Pro-Val-Val-His-Phe P MS His Gly Arg Pro Gln Asp Glu Asn Brandt et al., 2005
oxytocin P01178 20-28 Cys-Tyr-Ile-Gln-Asn-Cys-Pro+Leu-Gly-NH2 N Gln Asn Cys Pro Leu Gly NH2 - Koida & Walter, 1976 3722
substance P P20366 58-68 peptide-Pro4+Gln-peptide N Arg Pro Lys Pro Gln Gln Phe Phe Mäkinen et al., 1995 21565
Suc-Ala-Pro-Ala-NHPhNO2 Suc-Ala-Pro-Ala+NHPhNO2 S Suc Ala Pro Ala NAN - - - Shan et al., 2004
Suc-Ala-Pro-Ala-NHPhNO2 Suc-Ala-Pro-Ala+NHPhNO2 S Suc Ala Pro Ala NAN - - - Shan et al., 2004
Suc-Ala-Pro-Ala-NHPhNO2 Suc-Ala-Pro-Ala+NHPhNO2 S Suc Ala Pro Ala NAN - - - Shan et al., 2004
Suc-Gly-Pro-NHMec Suc-Gly-Pro+NHMec S - Suc Gly Pro AMC - - -
thymosin beta-4 P62328 2-44 peptide-Pro5+Asp-peptide P CS Ser Asp Lys Pro Asp Met Ala Glu Cavasin et al., 2004
vasopressin Cys-Tyr-Phe-Gln-Asn-Cys-Pro+Arg-Gly N Gln Asn Cys Pro Arg Gly - - Ito et al., 2004
Z-Gly-Pro-Leu-Gly Z-Gly-Pro+Leu-Gly S - Z Gly Pro Leu Gly - - Ito et al., 2004
Z-Gly-Pro-NHMec Z-Gly-Pro+NHMec S - Z Gly Pro AMC - - - Ito et al., 2004
Z-Gly-Pro-NHNap Z-Gly-Pro+NHNap S - Z Gly Pro NAP - - - Ito et al., 2004
Z-Gly-Pro-NHPhNO2 Z-Gly-Pro+NHPhNO2 S - Z Gly Pro NAN - - - Ito et al., 2004
Z-Gly-Pro-NHPhNO2 Z-Gly-Pro+NHPhNO2 S - Z Gly Pro NAN - - - Mäkinen et al., 1994

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