Substrates for peptidase M03.006: mitochondrial intermediate peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
60 kDa heat shock protein, mitochondrial precursor	P10809	18-573	peptide-Tyr26+Ala-peptide	P	MS	Thr	Arg	Ala	Tyr	Ala	Lys	Asp	Val	Gevaert et al., 2003
Abz-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Gln-EDDnp			Abz-Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg-Gln-EDDnp	S		Pro	Pro	Gly	Phe	Ser	Pro	Phe	Arg	Marcondes et al., 2010
Abz-Asn-Leu-Met-Lys-Lys-Ser-Thr-Lys(Dnp)-NH2			Abz-Asn-Leu-Met+Lys-Lys-Ser-Thr-Lys(Dnp)-NH2	S		Abz	Asn	Leu	Met	Lys	Lys	Ser	Thr	Marcondes et al., 2015
Abz-FRSGQPLQNKVQLQ-EDDnp			Abz-FRSGQPLQ+NKVQLQ-EDDnp	S		Gln	Pro	Leu	Gln	Asn	Lys	Val	Gln	Marcondes et al., 2015
Abz-Gln-Pro-Leu-Ala-Asn-Lys-Val-Gln-EDDnp			Abz-Gln-Pro-Leu-Ala+Asn-Lys-Val-Gln-EDDnp	S		Gln	Pro	Leu	Ala	Asn	Lys	Val	Gln	Marcondes et al., 2015
Abz-Gln-Pro-Leu-Gln-Ala-Lys-Val-Gln-EDDnp			Abz-Gln-Pro-Leu-Gln+Ala-Lys-Val-Gln-EDDnp	S		Gln	Pro	Leu	Gln	Ala	Lys	Val	Gln	Marcondes et al., 2015
Abz-Gln-Pro-Leu-Gln-Asn-Lys-Val-Gln-EDDnp			Abz-Gln-Pro-Leu-Gln+Asn-Lys-Val-Gln-EDDnp	S		Gln	Pro	Leu	Gln	Asn	Lys	Val	Gln	Marcondes et al., 2015
Abz-Gly-Phe-Ser-Pro-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe+Ser-Pro-Phe-Arg-Gln-EDDnp	S		-	Abz	Gly	Phe	Ser	Pro	Phe	Arg	Marcondes et al., 2010
Abz-Ile-Lys-Gln-Ser-Ser-Leu-Leu-Lys(Dnp)-NH2			Abz-Ile-Lys-Gln+Ser-Ser-Leu-Leu-Lys(Dnp)-NH2	S		Abz	Ile	Lys	Gln	Ser	Ser	Leu	Leu	Marcondes et al., 2015
Abz-Met-Thr-Ala-Ala-Leu-Lys-Thr-Lys(Dnp)-NH2			Abz-Met-Thr+Ala-Ala-Leu-Lys-Thr-Lys(Dnp)-NH	S		-	Abz	Met	Thr	Ala	Ala	Leu	Lys	Marcondes et al., 2015
Abz-Met-Thr-Ala-Ala-Leu-Lys-Thr-Lys(Dnp)-NH2			Abz-Met-Thr-Ala-Ala-Leu-Lys+Thr-Lys(Dnp)-NH	S		Ala	Ala	Leu	Lys	Thr	Lyd	NH2	-	Marcondes et al., 2015
Abz-Phe-Gln-Thr-Lys-Val-Ala-Ala-Lys(Dnp)-NH2			Abz-Phe-Gln+Thr-Lys-Val-Ala-Ala-Lys(Dnp)-NH2	S		-	Abz	Phe	Gln	Thr	Lys	Val	Ala	Marcondes et al., 2015
Abz-Phe-Ser-Ser-Lys-Thr-Thr-Val-Lys(Dnp)-NH2			Abz-Phe-Ser+Ser-Lys-Thr-Thr-Val-Lys(Dnp)-NH2	S		-	Abz	Phe	Ser	Ser	Lys	Thr	Thr	Marcondes et al., 2015
Abz-Thr-Thr-Lys-Leu-Lys-Ala-Ala-Lys(Dnp)-NH2			Abz-Thr-Thr-Lys-Leu+Lys-Ala-Ala-Lys(Dnp)-NH2	S		Thr	Thr	Lys	Leu	Lys	Ala	Ala	Lys	Marcondes et al., 2015
Abz-Thr-Thr-Lys-Leu-Lys-Ala-Ala-Lys(Dnp)-NH2			Abz-Thr-Thr-Lys-Leu-Lys+Ala-Ala-Lys(Dnp)-NH2	S		Thr	Lys	Leu	Lys	Ala	Ala	Lys	NH2	Marcondes et al., 2015
Abz-Thr-Thr-Lys-Leu-Lys-Ala-Ala-Lys(Dnp)-NH2			Abz-Thr-Thr-Lys-Leu-Lys-Ala+Ala-Lys(Dnp)-NH2	S		Lys	Leu	Lys	Ala	Ala	Lys	NH2	-	Marcondes et al., 2015
Abz-Trp-Thr-Thr-Gly-Gly-Lys-Ala-Lys(Dnp)-NH2			Abz-Trp-Thr+Thr-Gly-Gly-Lys-Ala-Lys(Dnp)-NH2	S		-	Abz	Trp	Thr	Thr	Gly	Gly	Lys	Marcondes et al., 2015
Abz-Val-Ala-Ala-Gln-Thr-Lys-Thr-Lys(Dnp)-NH2			Abz-Val-Ala-Ala+Gln-Thr-Lys-Thr-Lys(Dnp)-NH2	S		Abz	Val	Ala	Ala	Gln	Thr	Lys	Thr	Marcondes et al., 2015
Abz-Val-Ile-Ser-Ser-Arg-Leu-Glu-Lys(Dnp)-NH2			Abz-Val-Ile-Ser+Ser-Arg-Leu-Glu-Lys(Dnp)-NH2	S		Abz	Val	Ile	Ser	Ser	Arg	Leu	Glu	Marcondes et al., 2015
Abz-VRNFRSGQPLQNKVQ-EDDnp			Abz-VRNFRSGQPLQ+NKVQ-EDDnp	S		Gln	Pro	Leu	Gln	Asn	Lys	Val	Gln	Marcondes et al., 2015
ATP synthase subunit alpha, mitochondrial precursor	P25705	36-553	peptide-Leu43+Gln-peptide	P	MS	Asn	Thr	His	Leu	Gln	Lys	Thr	Gly	Gevaert et al., 2003
ATP synthase subunit O, mitochondrial precursor	P48047	16-213	peptide-Pro23+Phe-peptide	P	MS	Val	Val	Arg	Pro	Phe	Ala	Lys	Leu	Van Damme P et al., 2005
ATP synthase-coupling factor 6, mitochondrial precursor	P18859	25-108	peptide-Phe32+Asn-peptide	P	MS	Ala	Val	Ala	Phe	Asn	Lys	Glu	Leu	Van Damme P et al., 2005
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg	N		Pro	Pro	Gly	Phe	Ser	Pro	Phe	Arg	Isaya, 2004	16438
cytochrome C oxidase polypeptide IV, mitochondrial precursor	P04037	18-155	peptide-Leu25+Gln-peptide	P		Arg	Tyr	Leu	Leu	Gln	Gln	Lys	Pro	Hendrick et al., 1989
malate dehydrogenase, mitochondrial precursor	P08249	17-338	peptide-Asn24+Ala-peptide	P		Ala	Gln	Asn	Asn	Ala	Lys	Val	Ala	Hendrick et al., 1989
malate dehydrogenase, mitochondrial precursor	P04636	17-338	peptide-Asn24+Ala-peptide	P		Ala	Gln	Asn	Asn	Ala	Lys	Val	Ala	Hendrick et al., 1989
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor	P19404	25-249	peptide-Asn32+Gly-peptide	P	MS	Val	Met	Gln	Asn	Gly	Ala	Gly	Gly	Van Damme P et al., 2005
ornithine carbamoyltransferase, mitochondrial precursor	P00481	25-354	peptide-Gln32+Ser-peptide	P		Lys	Pro	Val	Gln	Ser	Gln	Val	Gln	Sztul etal, 1987
ornithine carbamoyltransferase, mitochondrial precursor	P11725	25-354	peptide-Gln32+Ser-peptide	P		Lys	Pro	Val	Gln	Ser	Gln	Val	Gln	Hendrick et al., 1989
ornithine carbamoyltransferase, mitochondrial precursor	P00480	25-354	peptide-Gln32+Asn-peptide	P		Gln	Pro	Leu	Gln	Asn	Lys	Val	Gln	Hendrick et al., 1989
peptidyl-prolyl cis-trans isomerase, mitochondrial precursor	P10255	37-223	peptide-Met44+Ser-peptide	P		Ser	Ser	Ile	Met	Ser	Lys	Val	Phe	Hendrick et al., 1989
peroxiredoxin-5, mitochondrial	P99029	42-210	peptide-Met49+Ala-peptide	P	NT	Ala	Val	Thr	Met	Ala	Pro	Ile	Lys	Sim et al., 2021
ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor	P07056	25-231	peptide-Gln32+Gly-peptide	P		Thr	Ala	Leu	Gln	Gly	Ser	Ser	Ser	Hendrick et al., 1989