Substrates for peptidase S28.002: dipeptidyl-peptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Ala-Ala Ala-Ala+Ala N - - Ala Ala Ala - - - McDonald et al., 1968
Ala-Ala-NHNap Ala-Ala+NHNap S - - Ala Ala NAP - - -
Ala-Ala-NHPhNO2 Ala-Ala+NHPhNO2 S - - Ala Ala NAN - - - McDonald & Ohkubo, 2004
Ala-Pro-NHNap Ala-Pro+NHNap S - - Ala Pro NAP - - -
Arg-Ala-NHNap Arg-Ala+NHNap S - - Arg Ala NAP - - - McDonald & Ohkubo, 2004
Arg-Pro-NHNap Arg-Pro+NHNap S - - Arg Pro NAP - - -
beta-casomorphin Tyr-Pro+Phe-Pro-Gly-Pro-Ile N - - Tyr Pro Phe Pro Gly Pro McDonald & Ohkubo, 2004
beta-casomorphin 2-6 Phe-Pro+Gly-Pro-Ile N - - Phe Pro Gly Pro Ile - McDonald & Ohkubo, 2004
bradykinin (1-3) P01042 381-383 Arg-Pro+Pro N - - Arg Pro Pro - - - McDonald & Ohkubo, 2004
bradykinin (1-5) P01042 381-385 Arg-Pro+Pro-Gly-Phe N - - Arg Pro Pro Gly Phe - McDonald & Ohkubo, 2004
Glu-Pro-NHPhNO2 Glu-Pro+NHPhNO2 S - - Glu Pro NAN - - - McDonald & Ohkubo, 2004
Gly-Hyp-Ala Gly-Hyp+Ala N - - Gly Hyp Ala - - - McDonald & Ohkubo, 2004
Gly-Pro-NHMec Gly-Pro+NHMec S - - Gly Pro AMC - - - McDonald & Ohkubo, 2004
Gly-Pro-NHNap Gly-Pro+NHNap S - - Gly Pro NAP - - -
Gly-Pro-NHPhNO2 Gly-Pro+NHPhNO2 S - - Gly Pro NAN - - - McDonald & Ohkubo, 2004
His-Pro-Val His-Pro+Val N - - His Pro Val - - - McDonald & Ohkubo, 2004
Leu-Ala-NHNap Leu-Ala+NHNap S - - Leu Ala NAP - - - McDonald & Ohkubo, 2004
Lys-Ala-NHMec Lys-Ala+NHMec S - - Lys Ala AMC - - - McDonald & Ohkubo, 2004
Lys-Ala-NHNap Lys-Ala+NHNap S - - Lys Ala NAP - - - McDonald & Ohkubo, 2004
Lys-Pro-NHNap Lys-Pro+NHNap S - - Lys Pro NAP - - -
Lys-Pro-NHPhNO2 Lys-Pro+NHPhNO2 S - - Lys Pro NAN - - - McDonald & Ohkubo, 2004
Met-Met-Ala Met-Met+Ala N - - Met Met Ala - - - McDonald et al., 1968
Met-Met-Met Met-Met+Met N - - Met Met Met - - - McDonald et al., 1968
Phe-Pro-NHNap Phe-Pro+NHNap S - - Phe Pro NAP - - -
Pro-Pro-Gly Pro-Pro+Gly N - - Pro Pro Gly - - - McDonald & Ohkubo, 2004
Pro-Pro-Pro Pro-Pro+Pro N - - Pro Pro Pro - - - McDonald & Ohkubo, 2004
Ser-Met-Gln Ser-Met+Gln N - - Ser Met Gln - - - McDonald et al., 1968
Ser-Met-Glu Ser-Met+Glu N - - Ser Met Glu - - - McDonald et al., 1968
substance P P20366 58-68 Arg-Pro+Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 N - - Arg Pro Lys Pro Gln Gln McDonald & Ohkubo, 2004 17734
substance P 2-10 Lys-Pro+Gln-Gln-Phe-Phe-Gly-Leu-Met N - - Lys Pro Gln Gln Phe Phe McDonald & Ohkubo, 2004