Substrates for peptidase C01.088: oligopeptidase E

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
alpha-S1-casein	P02662	16-24	Arg-Pro-Lys18+His-Peptide	P	-	Arg	Pro	Lys	His	Pro	Ile	Lys	Sridhar et al., 2005
alpha-S1-casein	P02662	16-24	Peptide-Lys22+His-Gln	P	His	Pro	Ile	Lys	His	Gln	-	-	Sridhar et al., 2005
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly+Phe-Ser-Pro-Phe-Arg	N	Arg	Pro	Pro	Gly	Phe	Ser	Pro	Phe	Fenster et al., 2004	16101
Bz-Phe-Val-Arg-NHPhNO2			Bz-Phe-Val-Arg+NHPhNO2	S	Bz	Phe	Val	Arg	NAN	-	-	-	Fenster et al., 2004
Bz-Pro-Phe-Arg-NHPhNO2			Bz-Pro-Phe-Arg+NHPhNO2	S	Bz	Pro	Phe	Arg	NAN	-	-	-	Fenster et al., 2004
[Leu5]-enkephalin	P01210	230-234	Tyr-Gly-Gly+Phe-Leu-NH2	N	-	Tyr	Gly	Gly	Phe	Leu	NH2	-	Fenster et al., 2004
[Met5]-enkephalin	P01189	237-241	Tyr-Gly-Gly+Phe-Met-NH2	N	-	Tyr	Gly	Gly	Phe	Met	NH2	-	Chapot-Chartier & Mistou, 2004
[Met5]-enkephalin	P01189	237-241	Tyr-Gly+Gly-Phe-Met-NH2	N	-	-	Tyr	Gly	Gly	Phe	Met	NH2	Fenster et al., 2004