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Peptidase

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Substrates for peptidase M13.001: neprilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Gln-EDDnp Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Gln-EDDnp S Pro Arg Arg Pro Tyr Gln EDD - Oliveira et al., 2001
Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Gln-EDDnp Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Gln-EDDnp S Pro Arg Arg Pro Tyr Ile Gln EDD Oliveira et al., 2001
Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Gln-EDDnp Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr+Ile-Gln-EDDnp S Arg Arg Pro Tyr Ile Gln EDD - Oliveira et al., 2001
Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-Gln-EDDnp Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Leu-Gln-EDDnp S Pro Arg Arg Pro Tyr Ile Leu Gln Oliveira et al., 2001
Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-Gln-EDDnp Abz-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr+Ile-Leu-Gln-EDDnp S Arg Arg Pro Tyr Ile Leu Gln EDD Oliveira et al., 2001
Abz-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-Gln-EDDnp Abz-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Leu-Gln-EDDnp S Pro Arg Arg Pro Tyr Ile Leu Gln Oliveira et al., 2001
Abz-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-Gln-EDDnp Abz-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr+Ile-Leu-Gln-EDDnp S Arg Arg Pro Tyr Ile Leu Gln EDD Oliveira et al., 2001
Abz-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-Gln-EDDnp Abz-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Leu-Gln-EDDnp S Pro Arg Arg Pro Tyr Ile Leu Gln Oliveira et al., 2001
Abz-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-Gln-EDDnp Abz-Lys-Pro-Arg-Arg-Pro-Tyr+Ile-Leu-Gln-EDDnp S Arg Arg Pro Tyr Ile Leu Gln EDD Oliveira et al., 2001
angiotensin-1 P01019 34-43 Asp-Arg-Val-Tyr-Ile-His-Pro+Phe-His-Leu P LC Tyr Ile His Pro Phe His Leu - Stewart et al., 1981
angiotensin-1 P01019 34-43 Asp-Arg-Val-Tyr+Ile-His-Pro-Phe-His-Leu P LC Asp Arg Val Tyr Ile His Pro Phe Stewart et al., 1981
angiotensin-1 P01019 34-43 Asp-Arg+Val-Tyr-Ile-His-Pro-Phe-His-Leu P LC - - Asp Arg Val Tyr Ile His Stewart et al., 1981
angiotensin-2 P01019 34-41 Asp-Arg-Val+Tyr-Ile-His-Pro-Phe P LC - Asp Arg Val Tyr Ile His Pro Stewart et al., 1981
angiotensin-2 P01019 34-41 Asp-Arg+Val-Tyr-Ile-His-Pro-Phe P LC - - Asp Arg Val Tyr Ile His Stewart et al., 1981
atrial natriuretic factor P01160 124-151 peptide-Arg14+Ile-peptide P Arg Met Asp Arg Ile Gly Ala Gln Vanneste et al., 1988 3284
atrial natriuretic factor P01160 124-151 peptide-Gly16+Ala-peptide P Asp Arg Ile Gly Ala Gln Ser Gly Vanneste et al., 1988 3285
atrial natriuretic factor P01160 124-151 peptide-Gly20+Leu-peptide P Ala Gln Ser Gly Leu Gly Cys Asn Vanneste et al., 1988 3286
atrial natriuretic factor P01160 124-151 peptide-Arg11+Met-peptide P Phe Gly Gly Arg Met Asp Arg Ile Vanneste et al., 1988 3267
atrial natriuretic factor P01160 124-151 Ser-Leu-Arg-Arg+Ser-peptide P Ser Leu Arg Arg Ser Ser Cys Phe Vanneste et al., 1988 3266
atrial natriuretic factor P01160 124-151 peptide-Cys7+Phe-peptide P Arg Ser Ser Cys Phe Gly Gly Arg Vanneste et al., 1988 3254
atrial natriuretic factor P01160 124-151 peptide-Ser25+Phe-Arg-Tyr P Gly Cys Asn Ser Phe Arg Tyr - Vanneste et al., 1988 3287
beta-amyloid protein 42 P05067 672-713 peptide-Val689+Phe-peptide P Gln Lys Leu Val Phe Phe Ala Glu Yan et al., 2006
beta-amyloid protein 42 P05067 672-713 Asp-Ala+Phe-peptide P MS - Asp Ala Glu Phe Arg His Asp Yan et al., 2006
bradykinin P01042 381-389 Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg P Gly Phe Ser Pro Phe Arg - - Matsas et al., 1984 24364
bradykinin P01042 381-389 Arg-Pro-Pro-Gly+Phe-Ser-Pro-Phe-Arg N Arg Pro Pro Gly Phe Ser Pro Phe Matsas et al., 1984 24363
C-type natriuretic peptide P23582 105-126 peptide-Ser120+Met-peptide P Arg Ile Gly Ser Met Ser Gly Leu Watanabe et al., 1997 3264
C-type natriuretic peptide P23582 105-126 peptide-Lys114+Leu-peptide P Phe Gly Leu Lys Leu Asp Arg Ile Watanabe et al., 1997 3262
C-type natriuretic peptide P23582 105-126 peptide-Arg117+Ile-peptide P Lys Leu Asp Arg Ile Gly Ser Met Watanabe et al., 1997 3263
C-type natriuretic peptide P23582 105-126 peptide-Gly112+Leu-peptide P Gly Cys Phe Gly Leu Lys Leu Asp Watanabe et al., 1997 3261
C-type natriuretic peptide P23582 105-126 peptide-Cys110+Phe-peptide P Ser Lys Gly Cys Phe Gly Leu Lys Watanabe et al., 1997 3260
C-type natriuretic peptide P23582 105-126 peptide-Gly123+Leu-peptide P Ser Met Ser Gly Leu Gly Cys - Watanabe et al., 1997 3265
caspase-9 precursor Q53Y70 1-416 peptide-Asp330+Ala-peptide P Asp Gln Leu Asp Ala Ile Ser Ser 3084
chemotactic peptide formyl-Met+Leu-Phe N - - For Met Leu Phe - - Turner, 2004
cholecystokinin-8 P06307 96-103 Asp-Tyr-Met-Gly+Trp-Met-Asp-Phe-NH2 P Asp Tyr Met Gly Trp Met Asp Phe Turner, 2004
cholecystokinin-8 P06307 96-103 Asp-Tyr-Met-Gly-Trp-Met-Asp+Phe-NH2 N Gly Trp Met Asp Phe NH2 - - Turner, 2004
consensus-glycyl bond peptide-Gly+Phe-peptide N NPe Phe Phe Gly Phe Leu Ala CPe Turner, 2004
corticotropin P01189 138-176 Ser138+Tyr-peptide P MS - - - Ser Tyr Ser Met Glu Scholzen et al., 2007 24271
corticotropin P01189 138-176 peptide-Met141+Glu-peptide P MS Ser Tyr Ser Met Glu His Phe Arg Scholzen et al., 2007 24276
corticotropin P01189 138-176 peptide-Pro156+Val-peptide P MS Lys Arg Arg Pro Val Lys Val Tyr Scholzen et al., 2007 24280
corticotropin P01189 138-176 peptide-Lys158+Val-peptide P MS Arg Pro Val Lys Val Tyr Pro Asn Scholzen et al., 2007 24281
corticotropin P01189 138-176 peptide-Arg154+Arg-peptide P MS Gly Lys Lys Arg Arg Pro Val Lys Scholzen et al., 2007
corticotropin P01189 138-176 peptide-Pro149+Val-peptide P MS Trp Gly Lys Pro Val Gly Lys Lys Scholzen et al., 2007
corticotropin P01189 138-176 peptide-Asn162+Gly-peptide P MS Val Tyr Pro Asn Gly Ala Glu Asp Scholzen et al., 2007
corticotropin P01189 138-176 peptide-Trp146+Gly-peptide P MS His Phe Arg Trp Gly Lys Pro Val Scholzen et al., 2007
dynorphin-(1-9) P01213 207-215 Tyr-Gly-Gly+Phe-Leu-Arg-Arg-Ile-Arg N - Tyr Gly Gly Phe Leu Arg Arg Matsas et al., 1984 24366
dynorphin-(1-9) P01213 207-215 peptide-Phe210+Leu-peptide P Tyr Gly Gly Phe Leu Arg Arg Ile Matsas et al., 1984 24367
dynorphin-(1-9) P01213 207-215 peptide-Arg213+Ile-peptide P Phe Leu Arg Arg Ile Arg - - Matsas et al., 1984 24368
endothelin-1 P05305 53-73 peptide-Ser57+Leu-peptide P NT Ser Cys Ser Ser Leu Met Asp Lys Vijayaraghavan et al., 1990
endothelin-1 P05305 53-73 Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu+Ile-peptide P NT Cys His Leu Asp Ile Ile Trp - Vijayaraghavan et al., 1990
endothelin-1 P05305 53-70 Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His+Leu-Asp P NT Tyr Phe Cys His Leu Asp - - Vijayaraghavan et al., 1990
endothelin-2 P20800 49-69 Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu+Ile-peptide P NT Cys His Leu Asp Ile Ile Trp - Vijayaraghavan et al., 1990
endothelin-2 [1-18] P20800 49-67 Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His+Leu-Asp-Ile P NT Tyr Phe Cys His Leu Asp Ile - Vijayaraghavan et al., 1990
endothelin-3 P14138 97-117 Cys-Thr+Phe-peptide P NT - Cys Thr Cys Phe Thr Tyr Lys Vijayaraghavan et al., 1990
endothelin-3 P14138 97-117 peptide-Cys107+Val-peptide P NT Asp Lys Glu Cys Val Tyr Tyr Cys Vijayaraghavan et al., 1990
endothelin-3 P14138 97-117 Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu+Ile-peptide P NT Cys His Leu Asp Ile Ile Trp - Vijayaraghavan et al., 1990
endothelin-3 [1-16] P14138 97-114 Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His+Leu-Asp P NT Tyr Tyr Cys His Leu Asp - - Vijayaraghavan et al., 1990
gastrin P01350 76-92 peptide-Trp79+Leu-peptide P Gln Gly Pro Trp Leu Glu Glu Glu Pauwels et al., 1989 3275
gastrin P01350 76-92 peptide-Ala86+Tyr-peptide P Glu Glu Glu Ala Tyr Gly Trp Met Pauwels et al., 1989 3276
gastrin P01350 76-92 peptide-Gly88+Trp-peptide P Glu Ala Tyr Gly Trp Met Asp Phe Pauwels et al., 1989 3277
gastrin P01350 76-92 peptide-Asp91+Phe-peptide P Gly Trp Met Asp Phe Gly Arg Arg Pauwels et al., 1989 3278
glucagon P01275 98-128 peptide-Asp106+Val-peptide P MS Phe Thr Ser Asp Val Ser Ser Tyr Hupe-Sodmann et al., 1995
glucagon P01275 98-128 peptide-Ser109+Tyr-peptide P MS Asp Val Ser Ser Tyr Leu Glu Gly Hupe-Sodmann et al., 1995
glucagon P01275 98-128 peptide-Tyr110+Leu-peptide P MS Val Ser Ser Tyr Leu Glu Gly Gln Hupe-Sodmann et al., 1995
glucagon P01275 98-128 peptide-Glu118+Phe-peptide P MS Ala Ala Lys Glu Phe Ile Ala Trp Hupe-Sodmann et al., 1995
glucagon P01275 98-128 peptide-Phe119+Ile-peptide P MS Ala Lys Glu Phe Ile Ala Trp Leu Hupe-Sodmann et al., 1995
glucagon P01275 98-128 peptide-Trp122+Leu-peptide P MS Phe Ile Ala Trp Leu Val Lys Gly Hupe-Sodmann et al., 1995
glucagon-like peptide 1 (28-36) amide P01275 119-127 Phe-Ile-Ala-Trp+Leu-Val-Lys-Gly-Arg-Gly-Arg-Arg-Asp-Phe-Pro-Glu-Glu-Val P NT Phe Ile Ala Trp Leu Val Lys Gly Gao et al., 2021
Gonadoliberin-1 P01148 24-33 Peptide-Gly29+Leu-Arg-Pro-Gly N NT Trp Ser Tyr Gly Leu Arg Pro Gly Rose et al., 2002
Gonadoliberin-1 P01148 24-33 Gln-His-Trp-Ser27+Tyr-Peptide N NT Gln His Trp Ser Tyr Gly Leu Arg Rose et al., 2002
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Asn Gln His Leu Cya Gly Ser Kerr & Kenny, 1974 19604
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Kerr & Kenny, 1974 19605
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Gly Ser His Leu Val Glu Ala Leu Kerr & Kenny, 1974 19606
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Kerr & Kenny, 1974 19607
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Glu Ala Leu Tyr Leu Val Cya Kerr & Kenny, 1974 19608
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Kerr & Kenny, 1974 19609
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu+Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Ala Leu Tyr Leu Val Cya Gly Glu Kerr & Kenny, 1974 19610
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly+Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Gly Glu Arg Gly Phe Phe Tyr Thr Kerr & Kenny, 1974 19611
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Kerr & Kenny, 1974 19612
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala N Arg Gly Phe Phe Tyr Thr Pro Lys Kerr & Kenny, 1974 19613
lamina-associated polypeptide 2, isoform alpha P42166 33-37 Arg-Lys-Asp+Val-Tyr P LC - Arg Lys Asp Val Tyr - - Guerin et al., 1997
locustatachykinin-1 P16223 1-9 Gly-Pro-Ser-Gly+Phe-Tyr-Gly-Val-Arg-NH2 N MS Gly Pro Ser Gly Phe Tyr Gly Val Bland et al., 2007
Melanin-concentrating hormone P14200 147-165 peptide-Cys153+Met-peptide P NT Met Leu Arg Cys Met Leu Gly Arg Checler et al., 1992
Melanin-concentrating hormone P14200 147-165 peptide-Arg157+Val-peptide P NT Met Leu Gly Arg Val Tyr Arg Pro Checler et al., 1992
Melanin-concentrating hormone P14200 147-165 peptide-Cys162+Trp-Gln-Val P NT Tyr Arg Pro Cys Trp Gln Val - Checler et al., 1992
melanotropin alpha P01189 138-150 peptide-Pro149+Val P MS Trp Gly Lys Pro Val - - - Scholzen et al., 2007 24270
melanotropin alpha P01189 138-150 peptide-His143+Phe-peptide P MS Ser Met Glu His Phe Arg Trp Gly Scholzen et al., 2007 24272
melanotropin alpha P01189 138-150 peptide-Arg145+Trp-peptide P MS Glu His Phe Arg Trp Gly Lys Pro Scholzen et al., 2007 24273
melanotropin alpha P01189 138-150 peptide-Phe144+Arg-peptide P MS Met Glu His Phe Arg Trp Gly Lys Scholzen et al., 2007 24274
melanotropin alpha P01189 138-150 peptide-Glu142+His-peptide P MS Tyr Ser Met Glu His Phe Arg Trp Scholzen et al., 2007 24275
natriuretic peptides B P16860 103-134 peptide-Met106+Val-peptide P Ser Pro Lys Met Val Gln Gly Ser Watanabe et al., 1997
natriuretic peptides B P16860 103-134 peptide-Arg119+Ile-peptide P Lys Met Asp Arg Ile Ser Ser Ser Watanabe et al., 1997
Neuropeptide PDF O96690 83-100 peptide-Ser89+Leu-peptide P MS Leu Ile Asn Ser Leu Leu Ser Leu Isaac et al., 2007
neurotensin P30990 151-163 Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Leu N Pro Arg Arg Pro Tyr Ile Leu - Turner, 2004 17013
neurotensin P30990 151-163 Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr+Ile-Leu N Arg Arg Pro Tyr Ile Leu - - Turner, 2004 17012
Oxytocin P01178 20-28 peptide-Pro26+Leu-Gly-NH2 P Gln Asn Cys Pro Leu Gly NH2 - Johnson et al., 1984
physalaemin P08615 1-11 peptide-Lys6+Phe-peptide P Asp Pro Asn Lys Phe Tyr Gly Leu Matsas et al., 1984 24359
physalaemin P08615 1-11 peptide-Phe7+Tyr-peptide P Pro Asn Lys Phe Tyr Gly Leu Met Matsas et al., 1984 24360
physalaemin P08615 1-11 peptide-Gly9+Leu-peptide P Lys Phe Tyr Gly Leu Met NH2 - Matsas et al., 1984 24361
proadrenomedullin N-terminal 20 peptide (PAMP) P35318 22-41 Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys+Trp-Ala-Leu-Ser-Arg P Lys Trp Asn Lys Trp Ala Leu Ser Nagatomo et al., 1996 3271
proadrenomedullin N-terminal 20 peptide (PAMP) P35318 22-41 Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp+Ala-Leu-Ser-Arg P Trp Asn Lys Trp Ala Leu Ser Arg Nagatomo et al., 1996 3272
proadrenomedullin N-terminal 20 peptide (PAMP) P35318 22-41 Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala+Leu-Ser-Arg P Asn Lys Trp Ala Leu Ser Arg Gly Nagatomo et al., 1996 3273
proadrenomedullin N-terminal 20 peptide (PAMP) P35318 22-41 Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys+Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg P Phe Arg Lys Lys Trp Asn Lys Trp Nagatomo et al., 1996 3270
proadrenomedullin N-terminal 20 peptide (PAMP) P35318 22-41 Ala-Arg+Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg P - - Ala Arg Leu Asp Val Ala Nagatomo et al., 1996 3268
proadrenomedullin N-terminal 20 peptide (PAMP) P35318 22-41 Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu+Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg P Val Ala Ser Glu Phe Arg Lys Lys Nagatomo et al., 1996 3269
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln+Phe-Phe-Gly-Leu-Met-NH2 P Lys Pro Gln Gln Phe Phe Gly Leu Matsas et al., 1984 17014
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln-Phe+Phe-Gly-Leu-Met-NH2 N Pro Gln Gln Phe Phe Gly Leu Met Turner, 2004 17015
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly+Leu-Met-NH2 N Gln Phe Phe Gly Leu Met NH2 - Matsas et al., 1984
substance P (deamidated) Arg-Pro-Lys-Pro-Gln-Gln+Phe-Phe-Gly-Leu-Met S Lys Pro Gln Gln Phe Phe Gly Leu Matsas et al., 1984
Suc-Ala-Ala-Leu-NHPhNO2 Suc-Ala-Ala+Leu-NHPhNO2 S - Suc Ala Ala Leu NAN - - Turner, 2004
succinyl-Ala-Ala-Phe-NHMec succinyl-Ala-Ala+Phe-NHMec S - Suc Ala Ala Phe AMC - - Fisk et al., 2007
thimet oligopeptidase inhibitor Cpp-Ala-Ala+Phe-pAb N - NBk Ala Ala Phe pAb - - Barrett & Chen, 2004
[D-Ala2,Leu5]-enkephalin Tyr-D-Ala-Gly+Phe-Leu N - Tyr DAl Gly Phe Leu - - Matsas et al., 1984
[D-Ala2,Leu5]-enkephalinamide Tyr-D-Ala-Gly+Phe-Leu-NH2 N - Tyr DAl Gly Phe Leu NH2 - Matsas et al., 1984
[Des-Tyr1, Met5]enkephalin P01210 101-104 Gly-Gly102+Phe-Met N NT - - Gly Gly Phe Met - - Rose et al., 2002
[Leu5]-enkephalin P01213 175-179 Tyr-Gly-Gly+Phe-Leu-NH2 N - Tyr Gly Gly Phe Leu - - Matsas et al., 1984
[Leu5]-enkephalin-Arg6 Tyr-Gly-Gly+Phe-Leu-Arg N - Tyr Gly Gly Phe Leu Arg - Matsas et al., 1984
[Leu5]-enkephalin-Arg6 Tyr-Gly-Gly-Phe+Leu-Arg N Tyr Gly Gly Phe Leu Arg - - Matsas et al., 1984
[Leu5]-enkephalinamide Tyr-Gly-Gly+Phe-Leu-NH2 N - Tyr Gly Gly Phe Leu NH2 - Matsas et al., 1984
[Met5]-enkephalin Tyr-Gly-Gly+Phe-Met N - Tyr Gly Gly Phe Met - - Matsas et al., 1984
[Met5]-enkephalin-Arg6 Tyr-Gly-Gly+Phe-Met-Arg N - Tyr Gly Gly Phe Met Arg - Matsas et al., 1984
[Met5]-enkephalin-Arg6-Phe7 Tyr-Gly-Gly+Phe-Met-Arg-Phe N - Tyr Gly Gly Phe Met Arg Phe Matsas et al., 1984
[Nle11]-substance P Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly+Leu-Nle-NH2 N Gln Phe Phe Gly Leu Nle NH2 - Matsas et al., 1984
[Nle11]-substance P Arg-Pro-Lys-Pro-Gln-Gln+Phe-Phe-Gly-Leu-Nle-NH2 S Lys Pro Gln Gln Phe Phe Gly Leu Matsas et al., 1984
[Nle11]-substance P Arg-Pro-Lys-Pro-Gln-Gln-Phe+Phe-Gly-Leu-Nle-NH2 S Pro Gln Gln Phe Phe Gly Leu Met Matsas et al., 1984

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