Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Substrates for peptidase C01.100: cruzipain 2

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Ala-Leu-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-Ala-Leu-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz Ala Leu Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-His-Leu-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-His-Leu-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz His Leu Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-Leu-Gly-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp Abz-Leu-Gly+Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp S - Abz Leu Gly Met Ile Ser Leu Del Nery et al., 1997
Abz-Leu-Leu-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-Leu-Leu-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz Leu Leu Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Ala-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Ala-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Ala Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Arg-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Arg-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Arg Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Arg-Ser-Lys-Gln-EDDnp Abz-Lys-Leu-Arg-Arg-Ser-Lys-Gln-EDDnp S Abz Lys Leu Arg Arg Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Leu-Ser-Lys-Gln-EDDnp Abz-Lys-Leu-Arg-Leu-Ser-Lys-Gln-EDDnp S Abz Lys Leu Arg Leu Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Phe-Ala-Lys-Gln-EDDnp Abz-Lys-Leu-Arg+Phe-Ala-Lys-Gln-EDDnp S Abz Lys Leu Arg Phe Ala Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Phe-Phe-Lys-Gln-EDDnp Abz-Lys-Leu-Arg+Phe-Phe-Lys-Gln-EDDnp S Abz Lys Leu Arg Phe Phe Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Phe-Pro-Arg-Gln-EDDnp Abz-Lys-Leu-Arg+Phe-Ser-Pro-Gln-EDDnp S Abz Lys Leu Arg Phe Ser Pro Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Phe-Pro-Lys-Gln-EDDnp Abz-Lys-Leu-Arg+Phe-Pro-Lys-Gln-EDDnp S Abz Lys Leu Arg Phe Pro Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Phe-Ser-Arg-Gln-EDDnp Abz-Lys-Leu-Arg+Phe-Ser-Arg-Gln-EDDnp S Abz Lys Leu Arg Phe Ser Arg Gln dos Reis et al., 2006
Abz-Lys-Leu-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Leu-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Leu Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Gly-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Leu-Gly+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Leu Gly Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Lys-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Leu-Lys+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Leu Lys Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Leu-Phe-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Leu-Phe+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Leu Phe Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Phe-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Phe-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Phe Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-Lys-Pro-Arg-Phe-Ser-Lys-Gln-EDDnp Abz-Lys-Pro-Arg+Phe-Ser-Lys-Gln-EDDnp S Abz Lys Pro Arg Phe Ser Lys Gln dos Reis et al., 2006
Abz-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp Abz-Met-Ile-Ser-Leu-Met+Lys-Arg-Pro-Gln-EDDnp S Ile Ser Leu Met Lys Arg Pro Gln Del Nery et al., 1997
epsilon-NH2-Cap-Leu-Cys(Bzl)-NHMec epsilon-NH2-Cap-Leu-Cys(Bzl)-NHMec S - Cap Leu CyB AMC - - - Lima et al., 2001
kininogen-1 P01042 19-644 peptide-Met379+Lys-peptide P NT Ile Ser Leu Met Lys Arg Pro Pro Del Nery et al., 1997
kininogen-1 P01042 19-644 peptide-Arg389+Ser-peptide P NT Ser Pro Phe Arg Ser Ser Arg Ile Del Nery et al., 1997
Z-Arg-Arg-NHMec Z-Arg-Arg+NHMec S - Z Arg Arg AMC - - - Lima et al., 2001
Z-Leu-Arg-NHMec Z-Leu-Arg+NHMec S - Z Leu Arg AMC - - - Lima et al., 2001
Z-Phe-Arg-NHMec Z-Phe-Arg+NHMec S - Z Phe Arg AMC - - - Lima et al., 2001

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use