Substrates for peptidase M01.002: lysyl aminopeptidase (bacteria)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-NHPhNO2 Ala+NHPhNO2 S - - - Ala NAN - - - Klein & Henrich, 2004
beta-casein P02666 208-224 Tyr+Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val P MS - - - Tyr Gln Glu Pro Val Soeryapranata et al., 2007
beta-casein P02666 209-224 Gln+Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val P MS - - - Gln Glu Pro Val Leu Soeryapranata et al., 2007
Bradykinin P01042 381-389 Arg381+Pro-Pro-Gly-Phe N MS - - - Arg Pro Pro Gly Phe Richards & Nuņez, 2006
Gly-NHPhNO2 Gly+NHPhNO2 S - - - Gly NAN - - - Klein & Henrich, 2004
Histatin-3 13/24 P15516 32-43 Lys32+Phe-His-Glu-Lys N MS - - - Lys Phe His Glu Lys Richards & Nuņez, 2006
Histatin-3 13/24 P15516 33-43 Phe33+His-Glu-Lys-His N MS - - - Phe His Glu Lys His Richards & Nuņez, 2006
Histatin-3 13/24 P15516 34-43 His34+Glu-Lys-His-His N MS - - - His Glu Lys His His Richards & Nuņez, 2006
Leu-NHNap Leu+NHNap S - - - Leu NAP - - - Klein & Henrich, 2004
Leu-NHPhNO2 Leu+NHPhNO2 S - - - Leu NAN - - - Klein & Henrich, 2004
Leu-NHPhNO2 Leu+NHPhNO2 S - - - Leu NAN - - - Klein & Henrich, 2004
Lys-NHMec Lys+NHMec S - - - Lys AMC - - - Klein & Henrich, 2004
Lys-NHPhNO2 Lys+NHPhNO2 S - - - Lys NAN - - - Klein & Henrich, 2004
Lys-Phe-Gly-Gly Lys+Phe-Gly-Gly N - - - Lys Phe Gly Gly - Klein & Henrich, 2004
Lysyl-bradykinin P01042 380-389 Lys380+Arg-Pro-Pro-Gly N MS - - - Lys Arg Pro Pro Gly Richards & Nuņez, 2006
Met-Ala-Ser Met1+Ala-peptide N - - - Met Ala Ser - - Klein & Henrich, 2004
Met-NHPhNO2 Met+NHPhNO2 S - - - Met NAN - - - Klein & Henrich, 2004
Neurokinin A P20366 98-107 His98+Lys-Thr-Asp-Ser N MS - - - His Lys Thr Asp Ser Richards & Nuņez, 2006
Neurokinin A P20366 98-107 Lys99+Thr-Asp-Ser-Phe N MS - - - Lys Thr Asp Ser Phe Richards & Nuņez, 2006
Phe-NHPhNO2 Phe+NHPhNO2 S - - - Phe NAN - - - Klein & Henrich, 2004
Pro-NHPhNO2 Pro+NHPhNO2 S - - - Pro NAN - - - Klein & Henrich, 2004
Tyr-NHPhNO2 Tyr+NHPhNO2 S - - - Tyr NAN - - - Klein & Henrich, 2004