Substrates for peptidase S09.008: dipeptidyl peptidase 4 (Aspergillus-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Ala-NHPhNO2 Ala-Ala+NHPhNO2 S - - Ala Ala NAN - - - Monod & Beauvais, 2004
Ala-Pro-NHPhNO2 Ala-Pro+NHPhNO2 S - - Ala Pro NAN - - - Monod & Beauvais, 2004
Arg-Pro-NHPhNO2 Arg-Pro+NHPhNO2 S - - Arg Pro NAN - - - Monod & Beauvais, 2004
glucagon-like peptide 1 His-Ala+Glu-peptide N - - His Ala Glu Gly Thr Phe Monod & Beauvais, 2004
Gly-Pro-NHMec Gly-Pro+NHMec S - - Gly Pro AMC - - - Monod et al., 2005
Gly-Pro-NHPhNO2 Gly-Pro+NHPhNO2 S - - Gly Pro NAN - - - Monod & Beauvais, 2004
neuropeptide Y Tyr-Pro+Ser-Lys N - - Tyr Pro Ser Lys - - Monod & Beauvais, 2004
[des-Arg]-bradykinin P01042 382-389 Pro-Pro+Gly-Phe-Ser-Pro-Phe-Arg N - - Pro Pro Gly Phe Ser Pro Monod & Beauvais, 2004