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Peptidase

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Substrates for peptidase M16.009: eupitrilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Ser-Gln-EDDnp Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr+Arg-Ser-Gln-EDDnp S Lys Val Val Thr Arg Ser Gln EDD Mzhavia & Devi, 2004
Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Ser-Gln-EDDnp Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg+Ser-Gln-EDDnp S Val Val Thr Arg Ser Gln EDD - Mzhavia et al., 1999
Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Val-Gln-EDDnp Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr+Arg-Val-Gln-EDDnp S Lys Val Val Thr Arg Val Gln EDD Mzhavia & Devi, 2004
Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Val-Gln-EDDnp Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Tyr-Arg+Val-Gln-EDDnp S Val Val Thr Arg Val Gln EDD - Mzhavia et al., 1999
Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Tyr-Arg-Ser-Gln-EDDnp Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Tyr+Arg-Ser-Gln-EDDnp S Lys Val Val Tyr Arg Ser Gln EDD Mzhavia & Devi, 2004
Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Tyr-Arg-Ser-Gln-EDDnp Abz-Arg-Arg-Gln-Phe-Lys-Val-Val-Tyr-Arg+Ser-Gln-EDDnp S Val Val Tyr Arg Ser Gln EDD - Mzhavia et al., 1999
Abz-Arg-Nle-Gln-Phe-Lys-Val-Val-Thr-Arg-Ser-Gln-EDDnp Abz-Arg-Nle-Gln-Phe-Lys-Val-Val-Tyr-Arg+Val-Gln-EDDnp S Val Val Thr Arg Ser Gln EDD - Mzhavia et al., 1999
Abz-norleucine-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Ser-Gln-EDDnp Abz-norleucine-Arg-Gln-Phe-Lys-Val-Val-Thr+Arg-Ser-Gln-EDDnp S Lys Val Val Thr Arg Ser Gln EDD Mzhavia & Devi, 2004
amyloid beta A4 protein P05067 18-770 peptide-Phe691+Ala-peptide P Leu Val Phe Phe Ala Glu Asp Val Falkevall et al., 2006 20985
angiotensin-1 P01019 34-43 peptide-Tyr37+Ile-peptide N MS Asp Arg Val Tyr Ile His Pro Phe Chow et al., 2009 24233
angiotensin-1 P01019 34-43 peptide-Pro40+Phe-peptide N MS Tyr Ile His Pro Phe His Leu - Chow et al., 2009 24234
atrial natriuretic factor P01160 124-151 peptide-Asp136+Arg-peptide N MS Gly Arg Met Asp Arg Ile Gly Ala Chow et al., 2009 24235
atrial natriuretic factor P01160 124-151 peptide-Ser148+Phe-peptide N MS Gly Cys Asn Ser Phe Arg Tyr - Chow et al., 2009 24236
beta-amyloid protein 40 P05067 672-711 peptide-Phe691+Ala-peptide N MS Leu Val Phe Phe Ala Glu Asp Val Chow et al., 2009
beta-amyloid protein 40 P05067 672-711 peptide-Leu705+Met-peptide N MS Ile Ile Gly Leu Met Val Gly Gly Chow et al., 2009 20990
Beta-amyloid protein 40 P05067 672-711 peptide-Gln686+Lys-peptide P MS Val His His Gln Lys Leu Val Phe Falkevall et al., 2006
Beta-amyloid protein 40 P05067 672-711 peptide-Lys687+Leu-peptide P MS His His Gln Lys Leu Val Phe Phe Falkevall et al., 2006
Beta-amyloid protein 40 P05067 672-711 peptide-Phe690+Phe-peptide P MS Lys Leu Val Phe Phe Ala Glu Asp Falkevall et al., 2006
Beta-amyloid protein 40 P05067 672-711 peptide-Ala701+Ile-peptide P MS Asn Lys Gly Ala Ile Ile Gly Leu Falkevall et al., 2006
Beta-amyloid protein 40 P05067 672-711 peptide-Gly704+Leu-peptide P MS Ala Ile Ile Gly Leu Met Val Gly Falkevall et al., 2006
Beta-amyloid protein 40 P05067 672-711 peptide-Gly700+Ala-peptide P MS Ser Asn Lys Gly Ala Ile Ile Gly Falkevall et al., 2006
Beta-amyloid protein 40 P05067 672-711 peptide-Gly709+Val-Val P MS Met Val Gly Gly Val Val - - Falkevall et al., 2006
beta-endorphin P01189 237-267 peptide-Gly239+Phe-peptide N MS - Tyr Gly Gly Phe Met Thr Ser Chow et al., 2009 24264
beta-endorphin P01189 237-267 peptide-Phe240+Met-peptide N MS Tyr Gly Gly Phe Met Thr Ser Glu Chow et al., 2009 24265
beta-endorphin P01189 237-267 peptide-Val251+Thr-peptide N MS Thr Pro Leu Val Thr Leu Phe Lys Chow et al., 2009 24266
beta-endorphin P01189 237-267 peptide-Thr252+Leu-peptide N MS Pro Leu Val Thr Leu Phe Lys Asn Chow et al., 2009 24267
beta-endorphin P01189 237-267 peptide-Leu253+Phe-peptide N MS Leu Val Thr Leu Phe Lys Asn Ala Chow et al., 2009 24268
beta-endorphin P01189 237-267 peptide-Ala257+Ile-peptide N MS Phe Lys Asn Ala Ile Ile Lys Asn Chow et al., 2009 24269
beta-neoendorphin-dynorphin P01214 228-240 peptide-Tyr228+Gly-peptide N MS - - - Tyr Gly Gly Phe Leu Chow et al., 2009
beta-neoendorphin-dynorphin P01214 228-240 peptide-Phe236+Lys-peptide N MS Arg Arg Gln Phe Lys Val Val Thr Chow et al., 2009
beta-neoendorphin-dynorphin P01214 228-240 peptide-Lys237+Val-peptide N MS Arg Gln Phe Lys Val Val Thr Arg Chow et al., 2009
bradykinin P01042 381-389 Arg-Pro-Pro-Gly+Phe-Ser-Pro-Phe-Arg N MS Arg Pro Pro Gly Phe Ser Pro Phe Chow et al., 2009 24237
calcitonin P01258 85-116 peptide-Lys102+Phe-peptide N MS Asp Phe Asn Lys Phe His Thr Phe Chow et al., 2009 24241
calcitonin P01258 85-116 peptide-Cys91+Met-peptide N MS Leu Ser Thr Cys Met Leu Gly Thr Chow et al., 2009 24239
calcitonin P01258 85-116 peptide-Gly94+Thr-peptide N MS Cys Met Leu Gly Thr Tyr Thr Gln Chow et al., 2009 24240
dynorphin A(1-13) P01214 209-221 peptide-Tyr209+Gly-peptide N MS - - - Tyr Gly Gly Phe Leu Chow et al., 2009
dynorphin A(1-13) P01214 209-221 peptide-Arg215+Ile-peptide N MS Phe Leu Arg Arg Ile Arg Pro Lys Chow et al., 2009
dynorphin A(1-13) P01214 209-221 peptide-Pro218+Lys-peptide N MS Arg Ile Arg Pro Lys Leu Lys Trp Chow et al., 2009
dynorphin A(1-17) P01213 207-223 peptide-Tyr175+Gly-peptide N MS - - - Tyr Gly Gly Phe Leu Chow et al., 2009 24242
dynorphin A(1-17) P01213 207-223 peptide-Arg213+Ile-peptide N MS Phe Leu Arg Arg Ile Arg Pro Lys Chow et al., 2009 24244
dynorphin A(1-17) P01213 207-223 peptide-Pro216+Lys-peptide N MS Arg Ile Arg Pro Lys Leu Lys Trp Chow et al., 2009 24247
dynorphin B P01213 226-238 peptide-Phe234+Lys-peptide N MS Arg Arg Gln Phe Lys Val Val Thr Chow et al., 2009 24245
dynorphin B P01213 226-238 peptide-Lys235+Val-peptide N MS Arg Gln Phe Lys Val Val Thr - Chow et al., 2009 24246
GHRH growth hormone releasing hormone preproprotein P01286 32-75 peptide-Tyr32+Ala-peptide N MS - - - Tyr Ala Asp Ala Ile Chow et al., 2009 24248
GHRH growth hormone releasing hormone preproprotein P01286 32-75 peptide-Gly46+Gln-peptide N MS Lys Val Leu Gly Gln Leu Ser Ala Chow et al., 2009 24249
GHRH growth hormone releasing hormone preproprotein P01286 32-75 peptide-Ser49+Ala-peptide N MS Gly Gln Leu Ser Ala Arg Lys Leu Chow et al., 2009 24250
GHRH growth hormone releasing hormone preproprotein P01286 32-75 peptide-Leu53+Leu-peptide N MS Ala Arg Lys Leu Leu Gln Asp Ile Chow et al., 2009 24251
leumorphin P01214 228-256 peptide-Thr13+Arg-peptide N Lys Val Val Thr Arg Ser Gln Glu 17046
leumorphin P01213 226-254 peptide-Arg239+Ser-peptide P Val Val Thr Arg Ser Gln Glu Asp Mzhavia et al., 1999 20219
leumorphin P01214 228-256 peptide-228+Gly-peptide N MS - - - Tyr Gly Gly Phe Leu Chow et al., 2009
leumorphin P01214 228-256 peptide-Lys237+Val-peptide N MS Arg Gln Phe Lys Val Val Thr Arg Chow et al., 2009
leumorphin P01214 228-256 peptide-Asp245+Pro-peptide N MS Ser Gln Glu Asp Pro Asn Ala Tyr Chow et al., 2009 24255
leumorphin P01214 228-256 peptide-Leu253+Phe-peptide N MS Tyr Glu Glu Leu Phe Asp Val - Chow et al., 2009 24254
leumorphin P01213 226-254 peptide-Tyr226+Gly-peptide N MS - - - Tyr Gly Gly Phe Leu Chow et al., 2009
leumorphin P01213 226-254 peptide-Phe234+Lys-peptide N MS Arg Arg Gln Phe Lys Val Val Thr Chow et al., 2009
leumorphin P01213 226-254 peptide-Lys235+Val-peptide N MS Arg Gln Phe Lys Val Val Thr Arg Chow et al., 2009
leumorphin P01213 226-254 peptide-Thr238+Arg-peptide N MS Lys Val Val Thr Arg Ser Gln Glu Chow et al., 2009
substance P P20366 58-68 peptide-Phe64+Phe-peptide N MS Pro Gln Gln Phe Phe Gly Leu Met Chow et al., 2009 24258
substance P P20366 58-68 peptide-Gly66+Leu-peptide N MS Gln Phe Phe Gly Leu Met - - Chow et al., 2009 24259
[Leu5]-enkephalin P01213 175-179 peptide-Tyr175+Gly-peptide N MS - - - Tyr Gly Gly Phe Leu Chow et al., 2009

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