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Substrates for peptidase S01.029: kallikrein-related peptidase 14

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Antileukoproteinase P03973 26-132 peptide-Arg45+Tyr-peptide P NT Gln Cys Leu Arg Tyr Lys Lys Pro Borgoņo et al., 2007
Antileukoproteinase P03973 26-132 peptide-Leu97+Met-peptide P NT Gly Gln Cys Leu Met Leu Asn Pro Borgoņo et al., 2007
Boc-Gln-Ala-Arg-NHMec Boc-Gln-Ala-Arg+NHMec S Boc Gln Ala Arg AMC - - - Borgoņo et al., 2007
Boc-Gln-Arg-Arg-NHMec Boc-Gln-Arg-Arg+NHMec S Boc Gln Arg Arg AMC - - - Borgoņo et al., 2007
Boc-Gln-Gly-Arg-NHMec Boc-Gln-Gly-Arg+NHMec S Boc Gln Gly Arg AMC - - - Borgoņo et al., 2007
Boc-Leu-Gly-Arg-NHMec Boc-Leu-Gly-Arg+NHMec S Boc Leu Gly Arg AMC - - - Borgoņo et al., 2007
Boc-Phe-Ser-Arg-NHMec Boc-Phe-Ser-Arg+NHMec S Boc Phe Ser Arg AMC - - - Borgoņo et al., 2007
Boc-Val-Leu-Lys-NHMec Boc-Val-Leu-Lys+NHMec S Boc Val Leu Lys AMC - - - Borgoņo et al., 2007
Boc-Val-Pro-Arg-NHMec Boc-Val-Pro-Arg+NHMec S Boc Val Pro Arg AMC - - - Borgoņo et al., 2007
COL4A2 collagen, type IV, alpha 2 P08572 184-1712 peptide-Arg1077+Ala-peptide P Ala Pro Gly Arg Ala Gly Leu Tyr Borgoņo et al., 2007 20940
COL4A2 collagen, type IV, alpha 2 P08572 184-1712 peptide-Arg1109+Gly-peptide P Lys Gly Glu Arg Gly Thr Thr Gly Borgoņo et al., 2007 20941
Desmoglein-1 Q02413 50-1049 peptide-Tyr528+Ser-peptide P NT Ser Gln Val Tyr Ser Ser Glu Pro Borgoņo et al., 2007
FGA fibrinogen, alpha polypeptide isoform alpha preproprotein P02671 20-866 peptide-Arg38+Val-peptide P Arg Gly Pro Arg Val Val Glu Arg Borgoņo et al., 2007 20947
FGA fibrinogen, alpha polypeptide isoform alpha preproprotein P02671 20-866 peptide-Arg510+His-peptide P Asp Gly Phe Arg His Arg His Pro Borgoņo et al., 2007 20948
fibrinogen beta chain P02675 31-491 peptide-Arg44+Gly-peptide P Phe Ser Ala Arg Gly His Arg Pro Borgoņo et al., 2007 20949
fibronectin P02751 32-2386 peptide-Arg290+Ala-peptide P Thr Asp Val Arg Ala Ala Val Tyr Borgoņo et al., 2007 20937
fibronectin P02751 32-2386 peptide-Arg903+Ser-peptide P Gly Thr Pro Arg Ser Asp Thr Val Borgoņo et al., 2007 20942
fibronectin P02751 32-2386 peptide-Arg2070+His-peptide P Thr Pro Ile Arg His Arg Pro Arg Borgoņo et al., 2007 20943
H-Pro-Phe-Arg-NHMec H-Pro-Phe-Arg+NHMec S - Pro Phe Arg AMC - - - Borgoņo et al., 2007
Kallikrein-1 precursor P06870 20-27 Ile-Gln-Ser-Arg24+Ile-Val-Gly N MS Ile Gln Ser Arg Ile Val Gly - Emami & Diamandis, 2008
Kallikrein-1 precursor P06870 19-262 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Emami & Diamandis, 2008
Kallikrein-10 precursor O43240 31-276 peptide-Arg42+Leu-peptide P NT Asn Asp Thr Arg Leu Asp Pro Glu Yoon et al., 2007
Kallikrein-11 precursor Q9UBX7 50-56 Glu-Thr-Arg53+Ile-Ile-Lys N MS - Glu Thr Arg Ile Ile Lys - Emami & Diamandis, 2008
Kallikrein-11 precursor Q9UBX7 51-282 Glu-Thr-Arg53+Ile-peptide P NT - Glu Thr Arg Ile Ile Lys Gly Emami & Diamandis, 2008
Kallikrein-12 precursor Q9UKR0 18-24 Ala-Thr-Pro-Lys21+Ile-Phe-Asn N MS Ala Thr Pro Lys Ile Phe Asn - Emami & Diamandis, 2008
Kallikrein-12 precursor Q9UKR0 18-248 Ala-Thr-Pro-Lys21+Ile-peptide P NT Ala Thr Pro Lys Ile Phe Asn Gly Yoon et al., 2007
Kallikrein-13 precursor Q9UKR3 17-277 peptide-Lys25+Val-peptide P NT Glu Ser Ser Lys Val Leu Asn Thr Yoon et al., 2007
Kallikrein-14 precursor Q9P0G3 35-267 peptide-Lys40+Ile-peptide P NT Asp Glu Asn Lys Ile Ile Gly Gly Yoon et al., 2007
Kallikrein-15 precursor Q9H2R5 17-256 peptide-Lys21+Leu-peptide P NT Asp Gly Asp Lys Leu Leu Glu Gly Yoon et al., 2007
Kallikrein-2 precursor P20151 20-27 Ile-Gln-Ser-Arg24+Ile-Val-Gly N MS Ile Gln Ser Arg Ile Val Gly - Emami & Diamandis, 2008
Kallikrein-2 precursor P20151 19-261 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Yoon et al., 2007
Kallikrein-5 Q9Y337 62-69 Ser-Ser-Ser-Arg66+Ile-Ile-Asn N MS Ser Ser Ser Arg Ile Ile Asn - Emami & Diamandis, 2008
Kallikrein-6 precursor Q92876 17-244 peptide-Lys21+Leu-peptide P NT Glu Gln Asn Lys Leu Val His Gly Yoon et al., 2007
Kallikrein-7 precursor P49862 25-32 Gln-Gly-Asp-Lys29+Ile-Ile-Asp N MS Gln Gly Asp Lys Ile Ile Asp - Emami & Diamandis, 2008
Kallikrein-9 precursor Q9UKQ9 16-250 peptide-Arg22+Ala-peptide P NT Ala Asp Thr Arg Ala Ile Gly Ala Yoon et al., 2007
kallikrein-related peptidase 14 Q9P0G3 25-251 peptide-Arg49+Ser-peptide P Thr Cys Thr Arg Ser Ser Gln Pro Borgoņo et al., 2007 20208
kallikrein-related peptidase 14 Q9P0G3 25-251 peptide-Arg63+Arg-peptide P Ala Gly Pro Arg Arg Arg Phe Leu Borgoņo et al., 2007 20209
kallikrein-related peptidase 14 Q9P0G3 25-251 peptide-Arg106+Thr-peptide P Tyr Asn Ser Arg Thr His Asp Asn Borgoņo et al., 2007 20210
kallikrein-related peptidase 14 Q9P0G3 25-251 peptide-Arg141+Ala-peptide P Arg Ile Gly Arg Ala Val Arg Pro Borgoņo et al., 2007 20211
kallikrein-related peptidase 14 Q9P0G3 25-251 peptide-Arg160+Val-peptide P Thr Ser Cys Arg Val Ser Gly Trp Borgoņo et al., 2007 20212
kallikrein-related peptidase 14 Q9P0G3 25-251 peptide-Arg173+Tyr-peptide P Pro Ile Ala Arg Tyr Pro Ala Ser Borgoņo et al., 2007 20213
kallikrein-related peptidase 14 Q9P0G3 25-251 peptide-Arg197+Thr-peptide P Ala Tyr Pro Arg Thr Ile Thr Pro Borgoņo et al., 2007 20214
kallikrein-related peptidase 5 Q9Y337 23-293 peptide-Arg66+Ile-peptide P Ser Ser Ser Arg Ile Ile Asn Gly Brattsand et al., 2005 21057
kininogen-1 P01042 19-644 peptide-Arg114+Ser-peptide P Val Gly Lys Arg Ser Ser Thr Lys Borgoņo et al., 2007 20946
laminin subunit alpha-5 O15230 36-3695 peptide-Arg2421+Asp-peptide P Glu Leu Ser Arg Asp Asn Ala Thr Borgo¤o et al., 2007
matrix metalloproteinase-14 P50281 24-582 peptide-Arg111+Tyr-peptide P NT Arg Arg Lys Arg Tyr Ala Ile Gln Falkowski et al., 2020
matrix metalloproteinase-15 P51511 48-669 peptide-Arg131+Tyr-peptide P NT Arg Arg Lys Arg Tyr Ala Leu Thr Falkowski et al., 2020
matrix metalloproteinase-15 P51511 48-669 peptide-Gly298+Ile-peptide P NT Asp Leu Arg Gly Ile Gln Gln Leu Falkowski et al., 2020
matrix metalloproteinase-16 P51512 76-607 peptide-Arg100+Cys-peptide P NT Lys Lys Pro Arg Cys Gly Val Pro Falkowski et al., 2020
matrix metalloproteinase-17 Q9ULZ9 40-603 peptide-Arg122+Arg-peptide P NT Thr Gln Ala Arg Arg Arg Arg Gln Falkowski et al., 2020
methoxysuccinyl-Val-Pro-Arg-NHMec methoxysuccinyl-Val-Pro-Arg+NHMec S MSu Val Pro Arg AMC - - - Felber et al., 2006
plasminogen P00747 20-810 peptide-Lys96+Lys-peptide P Leu Phe Glu Lys Lys Val Tyr Leu Borgoņo et al., 2007 20944
plasminogen P00747 20-810 peptide-Arg549+Lys-peptide P Thr Asn Pro Arg Lys Leu Tyr Asp Borgoņo et al., 2007 20945
Prostate-specific antigen P07288 25-261 peptide-Tyr153+Ala-peptide P NT Thr Thr Cys Tyr Ala Ser Gly Trp Emami & Diamandis, 2008
Prostate-specific antigen P07288 25-261 peptide-Lys169+Lys-peptide P NT Leu Thr Pro Lys Lys Leu Gln Cys Emami & Diamandis, 2008
Prostate-specific antigen precursor P07288 20-27 Ile-Leu-Ser-Arg24+Ile-Val-Gly N MS Ile Leu Ser Arg Ile Val Gly - Emami & Diamandis, 2008
Prostate-specific antigen precursor P07288 18-261 peptide-Arg24+Ile-peptide P NT Ile Leu Ser Arg Ile Val Gly Gly Emami & Diamandis, 2008
proteinase-activated receptor 1 P25116 27-425 peptide-Arg41+Ser-peptide P MS Leu Asp Pro Arg Ser Phe Leu Leu Oikonomopoulou et al., 2006 20599
proteinase-activated receptor 1 P25116 27-425 peptide-Phe43+Leu-peptide P MS Pro Arg Ser Phe Leu Leu Arg Asn Oikonomopoulou et al., 2006 20600
proteinase-activated receptor 1 P25116 27-425 peptide-Arg46+Asn-peptide P MS Phe Leu Leu Arg Asn Pro Asn Asp Oikonomopoulou et al., 2006 20601
proteinase-activated receptor 2 P55085 26-397 peptide-Arg36+Ser-peptide P MS Ser Lys Gly Arg Ser Leu Ile Gly Oikonomopoulou et al., 2006 20611
proteinase-activated receptor 2 P55085 26-397 peptide-Lys51+Gly-peptide P MS Val Thr Gly Lys Gly Val Thr Val Oikonomopoulou et al., 2006 20612
proteinase-activated receptor 2 P55085 26-397 peptide-Arg29+Ser-peptide P MS Gly Thr Asn Arg Ser Ser Lys Gly Oikonomopoulou et al., 2006 20613
proteinase-activated receptor 2 P55085 26-397 peptide-Lys34+Val-peptide P MS Leu Ile Gly Lys Val Asp Gly Thr Oikonomopoulou et al., 2006 20614
proteinase-activated receptor 2 Q63645 26-397 peptide-Arg36+Ser-peptide P MS Ser Lys Gly Arg Ser Leu Ile Gly Oikonomopoulou et al., 2006
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Tyr49+Pro-peptide P MS Pro Arg Gly Tyr Pro Gly Gln Val Oikonomopoulou et al., 2006 20618
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Gly35+Asp-peptide P MS Thr Gly Gly Gly Asp Asp Ser Thr Oikonomopoulou et al., 2006 20619
proteinase-activated receptor 4 precursor Q96RI0 18-385 peptide-Arg47+Gly-peptide P MS Pro Ala Pro Arg Gly Tyr Pro Gly Oikonomopoulou et al., 2006 20620
proteinase-activated receptor 4 precursor Q920E0 17-395 peptide-Arg49+Gly-peptide P MS Pro Asn Pro Arg Gly Phe Pro Gly Oikonomopoulou et al., 2006 20637
S-2222 Bz-Ile-Glu-Gly-Arg+NHPhNO2 S Ile Glu Gly Arg NAN - - - Brattsand et al., 2005
S-2288 D-Ile-Pro-Arg+NHPhNO2 S - DIl Pro Arg NAN - - - Brattsand et al., 2005
S-2302 D-Pro-Phe-Arg+NHPhNO2 S - DPr Phe Arg NAN - - - Brattsand et al., 2005
S-2586 MeO-Suc-Arg-Pro-Tyr+NHPhNO2 S Suc Arg Pro Tyr NAN - - - Brattsand et al., 2005
Somatotropin P01241 27-217 Peptide-Tyr169+Ser-Peptide P NT Lys Gln Thr Tyr Ser Lys Phe Asp Komatsu et al., 2007
Somatotropin P01241 27-217 Peptide-Arg90+Glu-Peptide P NT Pro Ser Asn Arg Glu Glu Thr Gln Komatsu et al., 2007
Tos-Gly-Pro-Arg-NHMec Tos-Gly-Pro-Arg+NHMec S Tos Gly Pro Arg AMC - - - Borgoņo et al., 2007
vitronectin P04004 20-478 peptide-Arg64+Gly-peptide P Gln Val Thr Arg Gly Asp Val Phe Borgoņo et al., 2007 20951
vitronectin P04004 20-478 peptide-Arg197+Asp-peptide P Lys Leu Ile Arg Asp Val Trp Gly Borgoņo et al., 2007 20952
Z-Gly-Gly-Arg-NHMec Z-Gly-Gly-Arg+NHMec S Z Gly Gly Arg AMC - - - Borgoņo et al., 2007

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