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Substrates for peptidase M35.001: penicillolysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ac-Lys-Thr-Lys-Gln-Leu-Arg-NHMec Ac-Lys-Thr-Lys-Gln-Leu-Arg+NHMec S Lys Gln Leu Arg AMC - - - Maeda et al., 2016
alpha-neoendorphin P01213 175-184 Tyr-Gly-Gly-Phe-Leu+Arg-Lys-Tyr-Pro-Lys N Gly Gly Phe Leu Arg Lys Tyr Pro Ichishima, 2004 17115
alpha-neoendorphin P01213 175-184 Tyr-Gly-Gly-Phe+Leu-Arg-Lys-Tyr-Pro-Lys N Tyr Gly Gly Phe Leu Arg Lys Tyr Ichishima, 2004 17114
Boc-Arg-Val-Arg-Arg-NHMec Boc-Arg-Val-Arg-Arg+NHMec S Arg Val Arg Arg AMC - - - Maeda et al., 2016
Boc-Gly-Arg-Arg-NHMec Boc-Gly-Arg-Arg+NHMec S Boc Gly Arg Arg AMC - - - Maeda et al., 2016
Boc-Leu-Arg-Arg-NHMec Boc-Leu-Arg-Arg+NHMec S Boc Leu Arg Arg AMC - - - Maeda et al., 2016
Boc-Leu-Lys-Arg-NHMec Boc-Leu-Lys-Arg+NHMec S Boc Leu Lys Arg AMC - - - Maeda et al., 2016
bradykinin P01042 381-389 Arg-Pro-Pro-Gly-Phe+Ser-Pro-Phe-Arg N Pro Pro Gly Phe Ser Pro Phe Arg Ichishima, 2004 17116
chicken brain pentapeptide Leu-Pro+Leu-Arg-Phe-NH2 N - - Leu Pro Leu Arg Phe NH2 Ichishima, 2004
dynorphin A(1-13) P01214 209-221 Tyr-Gly-Gly-Phe-Leu-Arg+Arg-Ile-Arg-Pro-Lys-Leu-Lys N Gly Phe Leu Arg Arg Ile Arg Pro Ichishima, 2004
dynorphin A(1-13) P01214 209-221 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro+Lys-Leu-Lys N Arg Ile Arg Pro Lys Leu Lys -
glutaryl-Ala-Ala-Phe-NHMec Glt-Ala-Ala-Phe+NHMec S Glt Ala Ala Phe AMC - - - Maeda et al., 2016
gonadoliberin-1 P01148 24-33 Glp-His-Trp+Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 N - Glp His Trp Ser Tyr Gly Leu Ichishima, 2004
gonadoliberin-1 P01148 24-33 Glp-His-Trp-Ser-Tyr+Gly-Leu-Arg-Pro-Gly-NH2 N His Trp Ser Tyr Gly Leu Arg Pro Ichishima, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Ichishima, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Ichishima, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N His Leu Val Glu Ala Leu Tyr Leu Ichishima, 2004
melanotropin alpha P01189 138-150 Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp+Gly-Lys-Pro-Val N His Phe Arg Trp Gly Lys Pro Val Ichishima, 2004 17113
melanotropin alpha P01189 138-150 Ser-Tyr+Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val N - - Ser Tyr Ser Met Glu His Ichishima, 2004 17111
melanotropin alpha P01189 138-150 Ser-Tyr-Ser-Met-Glu-His-Phe+Arg-Trp-Gly-Lys-Pro-Val N Met Glu His Phe Arg Trp Gly Lys Ichishima, 2004 17112
neurotensin P30990 151-163 Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg+Arg-Pro-Tyr-Ile-Leu N Asn Lys Pro Arg Arg Pro Tyr Ile Ichishima, 2004 17124
neurotensin P30990 151-163 Glp-Leu+Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu N - - Glp Leu Tyr Glu Asn Lys Ichishima, 2004
neurotensin P30990 151-163 Glp-Leu-Tyr-Glu-Asn-Lys-Pro+Arg-Arg-Pro-Tyr-Ile-Leu N Glu Asn Lys Pro Arg Arg Pro Tyr 17123
pGl-Arg-Thr-Lys-Arg-NHMec pGl-Arg-Thr-Lys-Arg+NHMec S Arg Thr Lys Arg AMC - - - Maeda et al., 2016
substance P P20366 58-68 Arg-Pro-Lys-Pro+Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 N Arg Pro Lys Pro Gln Gln Phe Phe Ichishima, 2004 17125
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly+Leu-Met-NH2 N Gln Phe Phe Gly Leu Met NH2 - Ichishima, 2004
substance P P20366 58-68 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe+Gly-Leu-Met-NH2 N Gln Gln Phe Phe Gly Leu Met NH2 Ichishima, 2004
Suc-Gly-Pro-NHMec Suc-Gly-Pro+NHMec S - Suc Gly Pro AMC - - - Maeda et al., 2016
Suc-Leu-Leu-Val-Tyr-NHMec Suc-Leu-Leu-Val-Tyr+NHMec S Leu Leu Val Tyr AMC - - - Maeda et al., 2016
Z-Arg-Arg-NHMec Z-Arg-Arg+NHMec S - Z Arg Arg AMC - - - Maeda et al., 2016
Z-Leu-Arg-NHMec Z-Leu-Arg+NHMec S - Z Leu Arg AMC - - - Maeda et al., 2016
Z-Leu-Leu-Glu-NHMec Z-Leu-Leu-Glu+NHMec S Z Leu Leu Glu AMC - - - Maeda et al., 2016
Z-Leu-Leu-Leu-NHMec Z-Leu-Leu-Leu+NHMec S Z Leu Leu Leu AMC - - - Maeda et al., 2016
Z-Pyr-Gly-Arg-NHMec Z-Pyr-Gly-Arg+NHMec S Z pGl Gly Arg AMC - - - Maeda et al., 2016
Z-Val-Lys-Met-NHMec Z-Val-Lys-Met+NHMec S Z Val Lys Met AMC - - - Maeda et al., 2016
Z-Val-Val-Arg-NHMec Z-Val-Val-Arg+NHMec S Z Val Val Arg AMC - - - Maeda et al., 2016

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